Publication

Design of Self-organizing Bio-inspired Systems

Daniel Mange, Joël Rossier
2007
Conference Papers

Abstract

Self-organizing bio-inspired systems borrow three structural principles characteristic of living organisms: multicellular architecture, cellular division, and cellular differentiation. Implemented in silicon according to these principles, our cellular systems become able to grow, to selfreplicate, and to self-repair. The growth and branching processes, performed by the so-called Tom Thumb algorithm, lead thus to the configuration and cloning mechanisms of the cellular systems. The repair processes allow its cicatrization and regeneration mechanisms. The functional and hardware designs of these mechanisms constitute the core of this paper.

Official source

https://infoscience.epfl.ch/entities/publication/fd4b996f-d125-4199-8473-5ea91b7d3d9c

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Daniel Mange, Joël Rossier
2007
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/fd4b996f-d125-4199-8473-5ea91b7d3d9c

About this result

Related concepts (16)

DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes.

Cellular differentiation

Cellular differentiation is the process in which a stem cell changes from one type to a differentiated one. Usually, the cell changes to a more specialized type. Differentiation happens multiple times during the development of a multicellular organism as it changes from a simple zygote to a complex system of tissues and cell types. Differentiation continues in adulthood as adult stem cells divide and create fully differentiated daughter cells during tissue repair and during normal cell turnover.

Nucleotide excision repair

Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases.

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