Roger HerschRoger D. Hersch is professor of Computer Science and head of the Peripheral Systems Laboratory at EPFL. He received his engineering degree from ETHZ in 1975, worked in industry from 1975 to 1980, and obtained his PhD degree from EPFL in 1985. He directed the widely known
Visible Human Web Server project
, which offers a number of services for the visualization of human anatomy.
His current research focuses on color reproduction, spectral color prediction models, moiré imaging, and visual document security. Recent achievements include the PhotoProtect technology, which incorporates text as chromatic differences in order to protect identity photographs (Swiss driving license), microstructure imaging, which is used by railways companies (SNCF, RENFE) and festival organizers (Paleo) to print tickets at home and the band moire imaging technology for the protection of security documents.
Rachid GuerraouiRachid Guerraoui has been affiliated with Ecole des Mines of Paris, the Commissariat à l'Energie Atomique of Saclay, Hewlett Packard Laboratories and the Massachusetts Institute of Technology. He has worked in a variety of aspects of distributed computing, including distributed algorithms and distributed programming languages. He is most well known for his work on (e-)Transactions, epidemic information dissemination and indulgent algorithms.
He co-authored a book on Transactional Systems (Hermes) and a book on reliable distributed programming (Springer). He was appointed program chair of ECOOP 1999, ACM Middleware 2001, IEEE SRDS 2002, DISC 2004 and ACM PODC 2010.
His publications are available at http://lpdwww.epfl.ch/rachid/papers/generalPublis.html Willy ZwaenepoelWilly Zwaenepoel received his B.S. from the University of Gent, Belgium in 1979, and his M.S. and Ph.D. from Stanford University in 1980 and 1984, respectively. In September 2002, he joined EPFL. He was Dean of the School of Computer and Communications Sciences at EPFL from 2002 to 2011. Before joining EPFL, Willy Zwaenepoel was on the faculty at Rice University, where he was the Karl F. Hasselmann Professor of Computer Science and Electrical and Computer Engineering.
He was elected Fellow of the IEEE in 1998, and Fellow of the ACM in 2000. In 2000 he received the Rice University Graduate Student Association Teaching and Mentoring Award. In 2007 he received the IEEE Tsutomu Kanai award. He was elected to the European Academy in 2009. He won best paper awards at SigComm 1984, OSDI 1999, Usenix 2000, Usenix 2006 and Eurosys 2007. He was program chair of OSDI in 1996 and Eurosys in 2006, and general chair of Mobisys in 2004. He was also an Associate Editor of the IEEE Transactions on Parallel and Distributed Systems from 1998 to 2002.
Willy Zwaenepoel has worked in a variety of aspects of operating and distributed systems, including microkernels, fault tolerance, parallel scientific computing on clusters of workstations, clusters for web services, mobile computing, database replication and virtualization. He is most well known for his work on the Treadmarks distributed shared memory system, which was licensed to Intel and became the basis for Intels OpenMP cluster product. His work on high-performance software for network I/O led to the creation of iMimic Networking, Inc, which he led from 2000 to 2005. His current interests include large-scale data stores and software testing. Most recently, his work in software testing led to the creation of BugBuster, a startup based in Lausanne.
Jean-François MolinariProfessor J.F. Molinari is the director of the Computational Solid Mechanics Laboratory (http://lsms.epfl.ch) at EPFL, Switzerland. He holds an appointment in the Civil Engineering institute, which he directed from 2013 to 2017, and a joint appointment in the Materials Science institute. He started his tenure at EPFL in 2007, and was promoted to Full Professor in 2012. He is currently an elected member of the Research Council of the Swiss National Science Foundation in Division 2 (Mathematics, Natural and Engineering Sciences), and co editor in chief of the journal Mechanics of Materials. J.F. Molinari graduated from Caltech, USA, in 2001, with a M.S. and Ph.D. in Aeronautics. He held professorships in several countries besides Switzerland, including the United States with a position in Mechanical Engineering at the Johns Hopkins University (2000-2006), and France at Ecole Normale Supérieure Cachan in Mechanics (2005-2007), as well as a Teaching Associate position at the Ecole Polytechnique de Paris (2006-2009). The work conducted by Prof. Molinari and his collaborators takes place at the frontier between traditional disciplines and covers several length scales from atomistic to macroscopic scales. Over the years, Professor Molinari and his group have been developing novel multiscale approaches for a seamless coupling across scales. The activities of the laboratory span the domains of damage mechanics of materials and structures, nano- and microstructural mechanical properties, and tribology. Luc ThévenazDe nationalité suisse et né à Genève, Luc Thévenaz a obtenu en 1982 le diplôme de physicien, mention astrophysique, de l'Université de Genève et le doctorat ès sciences naturelles, mention physique, en 1988 de l'Université de Genève. C'est durant ces années de thèse qu'il a développé son domaine d'excellence, en l'occurrence les fibres optiques et leurs applications. En 1988, Luc Thévenaz a rejoint l'Ecole Polytechnique Fédérale de Lausanne (EPFL), où il dirige actuellement un groupe de recherche en photonique, notamment en optique dans les fibres et dans les capteurs. Ses domaines de recherche couvrent les capteurs à fibre optique basés sur la diffusion Brillouin, l'optique non-linéaire dans les fibres, la lumière lente et rapide et la spectroscopie laser dans les gaz. Ses réalisations principales sont: - l'invention d'une configuration innovante pour les capteurs répartis Brillouin, basée sur l'emploi d'une seule source laser, ce qui lui donne une grande stabilité intrinsèque et qui a permis de réaliser les premières mesures hors laboratoire avec ce type de capteur; - le développement d'un capteur de gaz à l'état de traces, basé sur une détection photoacoustique et utilisant une source laser à semi-conducteur dans le proche infra-rouge, pouvant détecter une concentration du gaz au niveau du ppb; - la première démonstration expérimentale de lumière lente et rapide dans les fibres optiques qui puissent être contrôlées par un autre faisceau lumineux, réalisées à température ambiante et fonctionnant à n'importe quelle longueur d'onde grâce à l'exploitation de la diffusion Brillouin. La première vitesse de groupe négative dans les fibres a aussi été démontrée selon le même principe. En 1991, il a visité l'Université PUC de Rio de Janeiro au Brésil, où il a travaillé sur la génération d'impulsions picoseconde avec des diodes laser. En 1991-1992 il a travaillé à l'Université de Stanford aux USA, où il a participé au développement d'un gyroscope basé sur un laser Brillouin à fibre. Il a rejoint en 1998 l'entreprise Orbisphere Laboratories SA à Neuchâtel en Suisse en tant qu'expert scientifique, avec pour tâche de développer des capteurs de gaz à l'état de traces, basés sur la spectroscopie laser photoacoustique. En 1998 and 1999 il a visité le Korea Advanced Institute of Science and Technology (KAIST) à Daejon en Corée du Sud, où il a travaillé sur des capteurs de courant électrique utilisant un laser à fibre optique. En 2000 il a été un des co-fondateurs de l'entreprise Omnisens SA à Morges en Suisse, qui développe et commercialise de l'instrumentation et des capteurs optiques de pointe. En 2007 il a visité l'Université de Tel Aviv, où il a étudié le contrôle tout-optique de la polarisation de la lumière dans les fibres optiques. Durant l'hiver 2010, il a séjourné à l'Université de Sydney en Australie (CUDOS: Centre for Ultrahigh bandwidth Devices for Optical Systems) où il a étudié les apllications de la diffusion Brillouin stimulée dans les guides d'onde à base de verres chalcogénures. En 2014, il a séjourné à L'Université Polytechnique de Valence en Espagne, où il a travaillé sur les applications photoniques pour les micro-ondes exploitant la diffusion Brillouin stimulée. Il a été membre du Consortium formé pour le projet européen FP7 GOSPEL "Gouverner la vitesse de la lumière", a été Président de l'Action Européenne COST 299 "FIDES: Les fibres optiques pour relever les nouveaux défis de la société de l'information" et est auteur ou co-auteur de quelques 480 publications et 12 brevets. Il est actuellement Coordinateur du projet H2020 Marie Skłodowska-Curie Innovative Training Networks FINESSE (FIbre NErve Systems for Sensing). Il est co-Editeur-en-Chef de la revue "Nature Light: Science & Applications" et Membre du Comité Editorial (Editeur Associé) de la revues suivantes: "APL Photonics" et "Laser & Photonics Reviews". Il a été élevé au rang de "Fellow" par l'IEEE, ainsi que par la Société Optique (OSA).
Tobias KippenbergTobias J. Kippenberg is Full Professor of Physics at EPFL and leads the Laboratory of Photonics and Quantum Measurement. He obtained his BA at the RWTH Aachen, and MA and PhD at the California Institute of Technology (Caltech in Pasadena, USA). From 2005- 2009 he lead an Independent Research Group at the MPI of Quantum Optics, and is at EPFL since. His research interest are the Science and Applications of ultra high Q microcavities; in particular with his research group he discovered chip-scale Kerr frequency comb generation (Nature 2007, Science 2011) and observed radiation pressure backaction effects in microresonators that now developed into the field of cavity optomechanics (Science 2008). Tobias Kippenberg is alumni of the “Studienstiftung des Deutschen Volkes”. For his invention of “chip-scale frequency combs” he received he Helmholtz Price for Metrology (2009) and the EFTF Young Investigator Award (2010). For his research on cavity optomechanics, he received the EPS Fresnel Prize (2009). In addition he is recipient of the ICO Prize in Optics (2014), the Swiss National Latsis award (2015), the German Wilhelm Klung Award (2015) and ZEISS Research Award (2018). He is fellow of the APS and OSA, and listed since 2014 in the Thomas Reuters highlycited.com in the domain of Physics. EDUCATION 2009: Habilitation (Venia Legendi) in Physics, Ludwig-Maximilians-Universität München 2004: PhD, California Institute of Technology (Advisor Professor Kerry Vahala) 2000: Master of Science (Applied Physics), California Institute of Technology 1998: BA in Physics, Technical University of Aachen (RWTH), Germany 1998: BA in Electrical Engineering, Technical University of Aachen (RWTH), Germany ACADEMIC POSITIONS 2013 - present: Full Professor EPFL 2010 - 2012: Associate Professor EPFL 2008 - 2010: Tenure Track Assistant Professor, Ecole Polytechnique Federale de Lausanne 2007 - present: Marie Curie Excellent Grant Team Leader, Max Planck Institute of Quantum Optics (Division of Prof.T.W. Hänsch) 2005 - present: Leader of an Independent Junior Research Group, Max Planck Institute 2005- present: Habilitant (Prof. Hänsch) Ludwig-Maximilians-Universität (LMU) 2005-2006: Postdoctoral Scholar, Center for the Physics of Information, California Institute of Technology 2000-2004: Graduate Research Assistant, California Institute of Technology PRIZES AND HONORS: ZEISS Research Award 2018 Fellow of the APS 2016 Klung-Wilhelmy Prize 2015 Swiss Latsis Prize 2014 Selected Thomson Reuters Highly Cited Researcher in Physics, 2014/2015 ICO Prize, 2013 EFTF Young Scientist Award (for "invention of microresonator based frequency combs") 2010 Fresnel Prize of the European Physical Society (for contributions to Optomechanics) 2009 Helmholtz Prize for Metrology (for invention of the monolithic frequency comb) 2009 1st Prize winner of the EU Contest for Young Scientists, Helsinki, Finland. Sept. 1996 Jugend forscht 1st Physics Prize at the German National Science Contest May 1996 FELLOWSHIPS Fellow of the German National Merit Foundation ("Studienstiftung des Deutschen Volkes") 1998-2002 Member of the Daimler-Chysler-Fellowship-Organization 1998-2002 Dr. Ulderup Fellowship 1999-2000 RESEARCH INTERESTS Experimental and theoretical research in photonics, notably high Q optical microcavities and their use in cavity quantum optomechanics and frequency metrology PUBLICATIONS AND OFTEN CITED METRICS*: >70 Publications in peer reviewed journals Researcher Google Profile: http://scholar.google.ch/citations?user=PRCbG2kAAAAJ&hl=en h-Index 54 (Google scholar H: 64, >25,000 citations) Thomson Reuters/Claravite List of Highly Cited Researchers (2014,2015,2016,2017) careful in its use: https://www.aps.org/publications/apsnews/201411/backpage.cfm KEY PUBLICATIONS AND REVIEWS: A. Ghadimi, et al. Elastic strain engineering for ultra high Q nanomechanical oscillators Science, (2018) Trocha, et al. Ultrafast distance measurements using soliton microresonator frequency combs Science, Vol. 359 (2018) [joint work with C. Koos] Pablo-Marin et al. Microresonator-based solitons for massively parallel coherent optical communications Nature (2017) [joint work with C. Koos] V. Brasch, et al. Photonic chip-based optical frequency comb using soliton Cherenkov radiation. Science, vol. 351, num. 6271 (2015) Aspelmeyer, M., Kippenberg, T. J. & Marquardt, F. Cavity optomechanics. Reviews of Modern Physics 86, 1391-1452, (2014) Wilson, D. J. et al. Measurement and control of a mechanical oscillator at its thermal decoherence rate. Nature (2014). Verhagen, E., Deleglise, S., Weis, S., Schliesser, A. & Kippenberg, T. J. Quantum-coherent coupling of a mechanical oscillator to an optical cavity mode. Nature 482, 63-67 (2012). Kippenberg, T. J., Holzwarth, R. & Diddams, S. A. Microresonator-based optical frequency combs. Science 332, 555-559, (2011). Weis, S. et al. Optomechanically induced transparency. Science 330, 1520-1523 (2010). Kippenberg, T. J. & Vahala, K. J. Cavity optomechanics: back-action at the mesoscale. Science 321, 1172-1176, (2008). Del'Haye, P. et al. Optical frequency comb generation from a monolithic microresonator. Nature (2007) Schliesser, A., DelHaye, P., Nooshi, N., Vahala, K. & Kippenberg, T. Radiation Pressure Cooling of a Micromechanical Oscillator Using Dynamical Backaction. Physical Review Letters 97, (2006). Hans Peter HerzigDr. Hans Peter Herzig is Professor at the Ecole Polytechnique Fédérale de Lausanne (EPFL) and Past President of the European Optical Society (EOS). His current research interests include refractive and diffractive micro-optics, nano-scale optics and optical MEMS.
Hans Peter Herzig received his diploma in physics from the Swiss Federal Institute of Technology in Zürich, Switzerland, in 1978. From 1978 to 1982 he was a scientist with the Optics Development Department of Kern in Aarau, Switzerland, working in lens design and optical testing. In 1983, he became a graduate research assistant with the Applied Optics Group at the Institute of Microtechnology of the University of Neuchâtel, Switzerland, working in the field of holographic optical elements. In 1987, he received his PhD degree in optics. From 1989 to 2001 he was head of the micro-optics research group in Neuchâtel. From 2002 to 2008 he was a full professor and head of the Applied Optics Laboratory at the University of Neuchâtel. Professor Herzig joined the faculty at EPFL in January 2009.
He is member of OSA, IEEE Photonics Society and Fellow of EOS. 2009-2010 he was President of the European Optical Society (EOS), 2001-2009 Vice-President of the Swiss Society of Optics and Microscopy and 2012-2014 Vice-President of ICO. Dr. Herzig is in the editorial board of different scientific journals (JM3, Optical Review, JEOS). He served as Conference Chairman for international conferences of EOS, IEE, IEEE/LEOS, OSA and SPIE; and as Guest Editor of three special issues of IEEE, OSA journals. He is editor of a well-known book on micro-optics (published in English and Chinese), author of 14 book chapters, over 150 peer reviewed articles and 300 conference proceedings.
Jean-Pierre HubauxJean-Pierre Hubaux is a full professor at EPFL and head of the Laboratory for Data Security. Through his research, he contributes to laying the foundations and developing the tools for protecting privacy in today’s hyper-connected world. He has pioneered the areas of privacy and security in mobile/wireless networks and in personalized health. He is the academic director of the Center for Digital Trust (C4DT). He leads the Data Protection in Personalized Health (DPPH) project funded by the ETH Council and is a co-chair of the Data Security Work Stream of the Global Alliance for Genomics and Health (GA4GH). From 2008 to 2019 he was one of the seven commissioners of the Swiss FCC. He is a Fellow of both IEEE (2008) and ACM (2010). Recent awards: two of his papers obtained distinctions at the IEEE Symposium on Security and Privacy in 2015 and 2018. He is among the most cited researchers in privacy protection and in information security. Spoken languages: French, English, German, Italian
Hubert GiraultEducation: 1979 - Engineering diploma from Grenoble Institute of Technology. FRANCE. 1982 - PhD- Department of Chemistry, University of Southampton. Thesis entitled : Interfacial studies using drop image processing techniques. Positions : 1982 - 1984 SERC Research Fellow. University of Southampton. 1984 - 1985 CNRS Research Fellow. University of Southampton. 1985 - 1992 Lecturer in Physical Chemistry, University of Edinburgh. 1992 - Professor of Physical Chemistry, Ecole Polytechnique Fédérale de Lausanne. 2011 - 2014 Dean of Bachelor and Master studies Hubert Girault is the author of 2 textbooks, the co-author of about 600 scientific publications with more than 20'000 citations and the co-inventor of more than 15 patents. During his academic career, he has supervised 70 PhD students. 30 alumni of his laboratory are now Professors. Honours: Faraday medal 2006, Royal Society of Chemistry, Fellow of the International Society of Electrochemistry 2007, Reilley Award 2015. Fellow of the Electrochemical Society (USA), Shikata International medal, Polarography Society of Japan. Associate editor of Chemical Science
Alfred RuferOriginaire de Diessbach (BE), Alfred Rufer est né en 1951. Il obtient en 1976 le diplôme d'ingénieur électricien de l'EPFL et poursuit son activité dans le même établissement en tant qu'assistant à la chaire d'électronique industrielle. En 1993, il est nommé professeur-assistant au Laboratoire d'électronique industrielle. Au début 1996, il est nommé professeur extraordinaire. En 1978, il débute son activité dans l'industrie de l'électronique de grande puissance à la société ABB, Asea Brown Boveri à Turgi, où il contribue au développement d'entraînements réglés à fréquence variable. Dès 1985, il exerce la fonction d'assistant technique et de chef de groupe. De 1988 à 1991, il poursuit le développement de nouveaux systèmes d'électronique de puissance dans différents domaines d'application. A. Rufer est l'auteur et co-auteur de plusieurs demandes de brevet, ainsi que de plusieurs publications. De 1991 à 1992, il est chef d'un département de développement d'appareils d'électronique de réglage et de commande pour l'électronique de puissance. Durant son activité professionnelle dans l'industrie, il participe activement à l'enseignement technique dans plusieurs écoles d'ingénieurs.
Babak FalsafiBabak is a Professor in the School of Computer and Communication Sciences and the founding director of the EcoCloud, an industrial/academic consortium at EPFL investigating scalable data-centric technologies. He has made numerous contributions to computer system design and evaluation including a scalable multiprocessor architecture which was prototyped by Sun Microsystems (now Oracle), snoop filters and memory streaming technologies that are incorporated into IBM BlueGene/P and Q and ARM cores, and computer system performance evaluation methodologies that have been in use by AMD, HP and Google PerKit . He has shown that hardware memory consistency models are neither necessary (in the 90's) nor sufficient (a decade later) to achieve high performance in multiprocessor systems. These results eventually led to fence speculation in modern microprocessors. His latest work on workload-optimized server processors laid the foundation for the first generation of Cavium ARM server CPUs, ThunderX. He is a recipient of an NSF CAREER award, IBM Faculty Partnership Awards, and an Alfred P. Sloan Research Fellowship. He is a fellow of IEEE and ACM.
Karl AbererCo-Founder of LinkAlong Sarl, 2017.Vice-president EPFL for Information Systems, 2012 –2016.Director of the Swiss National Centre for Mobile Information and Communication Systems NCCR MICS (mics.ch), 2005 -2012.Member of the Swiss Research and Technology Council SWTR, consulting the Swiss Federal government, 2004 - 2011.
Andreas Peter BurgAndreas Burg was born in Munich, Germany, in 1975. He received his Dipl.-Ing. degree in 2000 from the Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland. He then joined the Integrated Systems Laboratory of ETH Zurich, from where he graduated with the Dr. sc. techn. degree in 2006.
In 1998, he worked at Siemens Semiconductors, San Jose, CA. During his doctoral studies, he was an intern with Bell Labs Wireless Research for a total of one year. From 2006 to 2007, he held positions as postdoctoral researcher at the Integrated Systems Laboratory and at the Communication Theory Group of the ETH Zurich. In 2007 he co-founded Celestrius, an ETH-spinoff in the field of MIMO wireless communication, where he was responsible for the ASIC development as Director for VLSI. In January 2009, he joined ETH Zurich as SNF Assistant Professor and as head of the Signal Processing Circuits and Systems group at the Integrated Systems Laboratory.
In January 2011, he became a Tenure Track Assistant Professor at the Ecole Polytechnique Federale de Lausanne (EPFL) where he is leading the Telecommunications Circuits Laboratory in the School of Engineering. In June 2018 he was promoted to the role of a Tenured Associate Professor.
In 2000, Mr. Burg received the Willi Studer Award and the ETH Medal for his diploma and his diploma thesis, respectively. Mr. Burg was also awarded an ETH Medal for his Ph.D. dissertation in 2006. In 2008, he received a 4-years grant from the Swiss National Science Foundation (SNF) for an SNF Assistant Professorship. In his professional career, Mr. Burg was involved in the development of more than 25 ASICs. He is a member of the IEEE and of the European Association for Signal Processing (EURASIP).
Research interests and expertise
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Circuits and systems for telecommunications (wireless and wired)
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Prototyping and silicon implementation of new communication technologies
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Development of communication algorithms and optimization for hardware implementation
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Low-power VLSI signal processing for communications and other applications
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Digital integrated circuits
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Circuits for image and video processing
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
