Publications associées à Abus de substances

Charge-Selectively Permeable Self-Healing Microcapsules

Microcapsules possessing a selective permeability are well-suited vessels for conducting cell studies or chemical reactions that require selective exchanges of reagents over a prolonged time. Most currently reported microcapsules are single-use delivery ca ...

WILEY2023

Selectively permeable microcapsules

Chuen-Ru Li

Microcapsules are appealing containers for delivering active ingredients, such as drugs and cosmetics, or conducting chemical and biological reactions on a small scale. To control the timing and location of release of these encapsulants, the shells of micr ...

EPFL2023

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Christoph Merten, Ngoc Hien Du

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, ...

Nature Research2022

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Lieu hologrammatique, un concept et une méthodologie complexe de mesure de l'organisation spatiale des réalités sociales

Thibault Pierre Louis Romany

The urban is a complex phenomenon whose exploration remains a important scientific challenge. Choosing complex thought in order to renew our capacities for understanding and action on and with the urban is not trivial. The complex thought developed by Edga ...

EPFL2020

Re-entry survival analysis and ground risk assessment of space debris considering by-products generation

Pénélope Leyland, Stefano Mischler, Seong-Hyeon Park

Space debris that re-enter the Earth's atmosphere can be partially or fully ablated along the trajectory path after hitting the atmosphere layers, once these become denser (approximately below 82 km). This paper combines re-entry survival analysis to by-pr ...

2020

A novel psychoanalytical approach: An electrochemical ligand-binding assay to screen antipsychotics

Sandro Carrara, Tugba Kilic

Schizophrenia treatment may see a paradigm shift due to development of new atypical antipsychotic drugs (APDs), with better tolerability due to more selective dopamine (DA) receptor blockade. Monitoring of these APD candidates in biological fluids is of gr ...

2018

Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum

Giovanni De Micheli, Nima Aliakbarinodehi, Sandro Carrara, Francesca Stradolini, Irene Taurino, Ioulia Tzouvadaki, Sattar Akbari Nakhjavani

Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the Electro-Active Surface Area (EASA). In this work, an analytical calculation of the deposited EASA is presented and experimentally validated b ...

2018

Impact Assessment of Pesticides Applied in Vegetable-Producing Areas in the Saharan Zone : the Case of Burkina Faso

Edouard René Gilbert Lehmann

The present thesis aimed at characterizing the extent of the pesticide contamination and resulting impacts on the environment and the human health in market garden-ing areas in Burkina Faso. Analytical procedures were developed and validated for multi-clas ...

EPFL2017

Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia

Erika Myrna Borcel Novoa

Although cocaine abuse is up to three times more frequent among schizophrenic patients, it remains unclear why this should be the case and whether sex influences this relationship. Using a maternal immune activation model of schizophrenia, we tested whethe ...

Pergamon-Elsevier Science Ltd2016

Device and method for injection, photoactivation and solidifaction of liquid embolic material in the vascular system or other organic cavities

Andreas Schmocker, Christophe Moser

The present invention concerns an organic cavity injection device including an injection cannula for injecting a photo-activatable substance inside an organic cavity; at least one element or a plurality of elements configured to control the removal of a re ...

2016

Effects of clofibric acid alone and in combination with 17 beta-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout

Kristin Schirmer

Clofibric acid (CA) is the active substance of lipid lowering drugs. It is resistant to degradation, polar in nature, and has been found ubiquitously in the aquatic environment. Though CA is classified as a peroxisomal proliferator in rodents and is consid ...

Pergamon-Elsevier Science Ltd2014

Emerging risks from ballast water treatment: The run-up to the International Ballast Water Management Convention

Urs von Gunten

Uptake and discharge of ballast water by ocean-going ships contribute to the worldwide spread of aquatic invasive species, with negative impacts on the environment, economies, and public health. The International Ballast Water Management Convention aims at ...

Elsevier2014

Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging

Mor-Miri Mishkovsky, Christophe Roussel, Andrea Capozzi, Jean-Noël Hyacinthe, Tian Cheng, Arnaud Comment, Najat Salameh, Yuhei Takado, Tim Rolf Eichhorn

Hyperpolarized substrates prepared via dissolution dynamic nuclear polarization have been proposed as magnetic resonance imaging (MRI) agents for cancer or cardiac failure diagnosis and therapy monitoring through the detection of metabolic impairments in v ...

National Academy of Sciences2013

Inferring about individual drug and schizotypy effects on cognitive functioning in polydrug using mephedrone users before and after clubbing

Christine Mohr, Daniela Herzig

Objective Mephedrone has been recently made illegal in Europe, but little empirical evidence is available on its impact on human cognitive functions. We investigated acute and chronic effects of mephedrone consumption on drug-sensitive cognitive measures, ...

Wiley-Blackwell2013

Alcohol consumption, alcohol dependence, and related mortality in Italy in 2004: effects of treatment-based interventions on alcohol dependence

Gerrit Gmel

Background: The tradition of consuming alcohol has long been a part of Italian culture and is responsible for a large health burden. This burden may be reduced with effective interventions, one of the more important of which is treatment for Alcohol Depend ...

Biomed Central Ltd2013

The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes

Pierre Magistretti, Jean-Marie Petit, Joël Gyger, Xinhe Liu

Sleep wake cycle is characterized by changes in neuronal network activity. However, for the last decade there is increasing evidence that neuroglial interaction may play a role in the modulation of sleep homeostasis and that astrocytes have a critical impa ...

Elsevier2013

Hypolimnetic Oxygen Depletion in Eutrophic Lakes

Alfred Johny Wüest, Beat Mueller

The oxygen-consuming processes in the hypolimnia of freshwater lakes leading to deep-water anoxia are still not well understood, thereby constraining suitable management concepts. This study presents data obtained from 11 eutrophic lakes and suggests a mod ...

Amer Chemical Soc2012

Parameterization Models for Pesticide Exposure via Crop Consumption

An approach for estimating human exposure to pesticides via consumption of six important food crops is presented that can be used to extend multimedia models applied in health risk and life cycle impact assessment. We first assessed the variation of model ...

Amer Chemical Soc2012

Infusion pump with phase separator

Arnaud Comment, Jacques Van Der Klink

An infusion pump comprising a substance and pushing fluid inlet, a substance outlet, a central chamber communicating with said inlet and said outlet, and injecting means for injecting a substance into a biological object, wherein the infusion pump further ...

2011