Publications associées à Mélanopsine

The circadian clock time tunes axonal regeneration

Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-dependent and-independent mechanisms have provided important insight into neuronal regeneration, however, common denominators underpinning regeneration remain ...

Cell Press2023

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

Cédric Gobet, Sylviane Métairon, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circad ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Incomplete Recovery of Zebrafish Retina Following Cryoinjury

Dylan Lawless

Zebrafish show an extraordinary potential for regeneration in several organs from fins to central nervous system. Most impressively, the outcome of an injury results in a near perfect regeneration and a full functional recovery. Indeed, among the various i ...

MDPI2022

Photovoltaic stimulation of retinal microcircuit for vision restoration

Naïg Aurelia Ludmilla Chenais

Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...

EPFL2021

Development of a new visual prosthesis for preclinical studies on artificial vision

Marta Jole Ildelfonsa Airaghi Leccardi

The technological evolution in materials science and microengineering favored the production of advanced visual prostheses useful for fighting blindness and to improve patients quality of life. Visual prostheses aim at replacing lost visual functions by ar ...

EPFL2020

Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi

Photovoltaic retinal prostheses theoretically offer the possibility of a standalone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging, because of axonal activation and electr ...

2019

Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons

Hasan Pezeshgi Modarres, Sha Li, Cyril Mikhail

Hypocretin/orexin (HCRT) and melanin concentrating hormone (MCH) neuropeptides are exclusively produced by the lateral hypothalamus and play important roles in sleep, metabolism, reward, and motivation. Loss of HCRT (ligands or receptors) causes the sleep ...

National Academy of Sciences2019

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

Semi-automatic 3D morphological reconstruction of neurons with densely branching morphology: Application to retinal All amacrine cells imaged with multi -photon excitation microscopy

Bas-Jan Zandt

Background: Accurate reconstruction of the morphology of single neurons is important for morphometric studies and for developing compartmental models. However, manual morphological reconstruction can be extremely time-consuming and error-prone and algorith ...

Elsevier2017

System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination

Christophe Moser, Timothé Laforest, Mathieu Künzi, Dino Carpentras

A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable a ...

2017

Rhythmic and clock-dependent chromatin loops regulate circadian gene expression

Jérôme Mermet

In mammals the circadian clock drives daily behavioural and physiological changes that resonate with environmental cues, which can be observed, for example, in the intricate timing of rest during the night and activity during the day in humans. The circadi ...

EPFL2017

Unified framework to evaluate non-visual spectral effectiveness of light for human health

Marilyne Andersen, María Lovísa Ámundadóttir, Steven W. Lockley

The discovery of a novel non-rod, non-cone photoreceptor in the mammalian eye that mediates a range of ‘non-visual’ responses to light has required reexamination of how lighting needs for human health are characterized and evaluated. Existing literature pr ...

SAGE Publications2017

Monitoring and rendering of visual and photo-biological properties of daylight-redirecting systems

Jean-Louis Scartezzini, Jérôme Henri Kämpf, Mirjam Münch, Apiparn Borisuit, Anothai Thanachareonkit

We previously developed a Camera-Like Light Sensor (CLLS) to record images using a novel High Dynamic Range (HDR) imaging vision sensor. The device was equipped with customized filters for adapting the camera’s spectral sensitivity to both photopic and cir ...

Pergamon-Elsevier Science Ltd2016

Light-driven model for identifying indicators of non-visual health potential in the built environment

María Lovísa Ámundadóttir

This thesis introduces a new approach to characterize and evaluate ocular light exposure based on the discovery of novel blue light-sensitive photoreceptors in the human eye. These photoreceptors are the primary mediators of 'non-visual' responses impactin ...

EPFL2016

Comparison of acute non-visual bright light responses in patients with optic nerve disease, glaucoma and healthy controls

Lorette Leon

This study examined the effect of optic nerve disease, hence retinal ganglion cell loss, on nonvisual functions related to melanopsin signalling. Test subjects were patients with bilateral visual loss and optic atrophy from either hereditary optic neuropat ...

Nature Publishing Group2015

Pupil responses derived from outer and inner retinal photo reception are normal in patients with hereditary optic neuropathy

Mirjam Münch, Lorette Leon

We compared the pupil responses originating from outer versus inner retinal photoreception between patients with isolated hereditary optic neuropathy (HON, n = 8) and healthy controls (n = 8). Three different testing protocols were used. For the first two ...

Academic Press Ltd- Elsevier Science Ltd2014

A framework for predicting the non-visual effects of daylight – Part II: The simulation model

Marilyne Andersen, Nicolas Roy

This paper describes a climate-based simulation framework devised to investigate the potential for the non-visual effects of daylight in buildings. It is part 2 of a study where the first paper focused on the formulation of the photobiological underpinning ...

SAGE Publications2014

Functional analysis of NR2E3 in retinal degenerations

The vertebrate retina is a model system of the development of the central nervous system. Because of its rapid development and the availability of many molecular tools the zebrafish is an established model of retinal development. Development and maintenanc ...

EPFL2014

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

Felix Naef, Jingkui Wang, Frédéric Bruno Martin Gachon, Daniel Alain Dominique Marie Mauvoisin, Florian Atger, Celine Jouffe

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known ab ...

National Academy of Sciences2014

Intrinsically photosensitive retinal ganglion cells: classification, function and clinical implications

Purpose of review The discovery of a new class of intrinsically photosensitive retinal ganglion cells (ipRGCs) revealed their superior role for various nonvisual biological functions, including the pupil light reflex, and circadian photoentrainment. Recent ...

Lippincott, Williams & Wilkins2013