Publications associées à Marge chirurgicale

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

Colorectal cancer is the second-leading cause of cancer death worldwide. Early-stage disease can be detected with preventative medical screening and is treatable with surgical resection. Sixty-percent of patients, however, are diagnosed with advanced-stage ...

EPFL2023

Improving the efficiency of identifying malignant pulmonary nodules before surgery via a combination of artificial intelligence CT image recognition and serum autoantibodies

Jiancheng Yang, Yi Ding, Zhen Gao

ObjectiveTo construct a new pulmonary nodule diagnostic model with high diagnostic efficiency, non-invasive and simple to measure. MethodsThis study included 424 patients with radioactive pulmonary nodules who underwent preoperative 7-autoantibody (7-AAB) ...

SPRINGER2022

Impact of combined use of intraoperative MRI and awake microsurgical resection on patients with gliomas: a systematic review and meta-analysis

Constantin Tuleasca

Microsurgical resection of primary brain tumors located within or near eloquent areas is challenging. Primary aim is to preserve neurological function, while maximizing the extent of resection (EOR), to optimize long-term neurooncological outcomes and qual ...

2021

Standardized intraoperative 5-ALA photodynamic therapy for newly diagnosed glioblastoma patients: a preliminary analysis of the INDYGO clinical trial

Constantin Tuleasca

Purpose Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The unfavorable prognosis despite maximal therapy relates to high propensity for recurrence. Thus, overall survival (OS) is quite limited and local failure remains the fundame ...

2021

Transsphenoidal resection for pituitary adenoma in elderly versus younger patients: a systematic review and meta-analysis

Constantin Tuleasca

Introduction Pituitary adenomas (PA) are common intracranial tumors. In the context of the aging of the population, the question is whether postsurgical outcomes are comparable to the younger ones. The primary objective of the present study was to review p ...

2020

Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma

Background Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The tumor microenvironment content, particularly the presence of macrophages, was described as crucial for the development of the disease. This wo ...

2020

Microfluidics-assisted multiplexed biomarker detection for in situ mapping of immune cells in tumor sections

Martinus Gijs, Daniel Migliozzi, Diego Gabriel Dupouy, Benjamin Pelz

Because of the close interaction between tumors and the immune system, immunotherapies are nowadays considered as the most promising treatment against cancer. In order to define the diagnosis and the subsequent therapy, crucial information about the immune ...

2019

Is detection of intraperitoneal exfoliated tumor cells after surgical resection of rectal cancer a prognostic factor of survival?

Paul Refinetti, Per Olaf Ekstrom

Background: The prognostic significance of free cancer cells detected in peritoneal fluid at the time of rectal surgery remains unclear. A substantial number of patients will develop metastatic disease even with successful local treatment. This prospective ...

2017

Time-resolved imaging system for fluorescence-guided surgery with lifetime imaging capability

Edoardo Charbon, Claudio Bruschini, Douglas Hanahan, François Eric Powolny, Harald Arjan Robert Homulle, Krisztian Homicsko, Riccardo Sinisi

We present a single-photon camera for fluorescence imaging, with a time resolution better than 100ps, capable of providing both intensity and lifetime images. the camera was fabricated in standard CMOS technology. With this FluoCam we show the possibility ...

Spie-Int Soc Optical Engineering2014

Assessing metastasis risk after pre-operative anti-angiogenic therapy

Michele De Palma, Daniela Biziato

Anti‐angiogenic drugs are approved for the treatment of several cancer types, generally in the inoperable locally advanced or metastatic setting and in combination with other anti‐cancer agents. Recent clinical studies also suggest that anti‐angiogenic dru ...

2014

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

Douglas Hanahan, Krisztian Homicsko, Anguraj Sadanandam, Stephan Wullschleger

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 ...

Nature Publishing Group2013

X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells

Giorgio Margaritondo

We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first ...

Nature Publishing Group2012

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

Douglas Hanahan, Anguraj Sadanandam

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease. Overall survival is typically 6 months from diagnosis(1). Numerous phase 3 trials of agents effective in other malignancies have failed to benefit unselected PDA populations, although patients do ...

Nature Publishing Group2011

High-magnification vascular imaging to reject false-positive sites in situ during Hexvix® fluorescence cystoscopy

Hubert van den Bergh, Georges Wagnières, Blaise Lovisa

Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix (R). Although the sensi ...

SPIE Society of Photo-optical Instrumentation Engineers2010

Photodynamic therapy for early squamous cell carcinomas of the esophagus, bronchi, and mouth with m-tetra(hydroxyphenyl) chlorin

Hubert van den Bergh, Georges Wagnières

Objective: To clinically evaluate a new photosensitizer, m- tetra(hydroxyphenyl) chlorin (m-THPC), for the photodynamic therapy of early squamous cell carcinomas of the upper aerodigestive tract. Design: Phase 1 included evaluation of the innocuousness of ...

1997