Publications associées à Syndrome de sevrage aux benzodiazépines

Functional MRI Neurofeedback Outperforms Cognitive Behavioral Therapy for Reducing Tinnitus Distress: A Prospective Randomized Clinical Trial

Dimitri Nestor Alice Van De Ville, Nicolas Gninenko

Background: Cognitive behavioral therapy (CBT) is the current standard treatment for chronic severe tinnitus; however, preliminary evidence suggests that real-time functional MRI (fMRI) neurofeedback therapy may be more effective. Purpose: To compare the e ...

Radiological Soc North America (Rsna)2024

Shared functional connectome fingerprints following ritualistic ayahuasca intake

Enrico Amico, Hanna Tolle, Pablo Mallaroni

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent s ...

Academic Press Inc Elsevier Science2023

Prefrontal engrams of long-term fear memory perpetuate pain perception

Johannes Gräff, Yechao Han

A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhan ...

NATURE PORTFOLIO2023

Two-stage Hardware-Friendly Epileptic Seizure Detection Method with a Dynamic Feature Selection

Alexandre Schmid, Keyvan Farhang Razi

A novel low-complexity method of detecting epileptic seizures from intracranial encephalography (iEEG) signals is presented. In the proposed algorithm, coastline, energy and nonlinear energy features of iEEG signals are extracted in a patient-specific two- ...

IEEE2021

Programming effects of peripubertal stress on spatial learning

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Cristina Marquez Vega

Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term ...

2020

Effect of furan pi-spacer and triethylene oxide methyl ether substituents on performance of phenothiazine sensitizers in dye-sensitized solar cells

Ulf Anders Hagfeldt

Conjugated pi-spacers are used to improve the light harvesting properties of sensitizers for dye-sensitized solar cells. In several recent works, furan has outperformed other popular pi-spacers such as thiophene and phenyl. One of the best performing pheno ...

ROYAL SOC CHEMISTRY2019

Auxiliary donors for phenothiazine sensitizers for dye-sensitized solar cells - how important are they really?

Ulf Anders Hagfeldt

Auxiliary donors are common design motifs for phenothiazine sensitizers for dye-sensitized solar cells. Despite this, there are only a few reports on their overall contribution to the photon-to-electron conversion efficiency. Twelve sensitizers have been p ...

Royal Society of Chemistry2019

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis, Jocelin Grosse, Ioannis Zalachoras, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Michael van der Kooij, Laura Lozano Montes, Sonia Abad Florensa

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

GABA A receptors in the ventral tegmental area control the outcome of a social competition in rats

Maria del Carmen Sandi Perez, Michael van der Kooij, Ioannis Zalachoras

Social dominance can be attained through social competitions. Recent work in both humans and rodents has identified trait anxiety as a crucial predictor of social competitiveness. In addition, the anxiolytic GABAA positive modulator, diazepam, injected eit ...

2018

NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans

Stewart Cole

During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinical outcome. We fou ...

Nature Research2017

Reducing GABA(A)-mediated inhibition improves forelimb motor function after focal cortical stroke in mice

Silvestro Micera, Stefano Lai

A deeper understanding of post-stroke plasticity is critical to devise more effective pharmacological and rehabilitative treatments. The GABAergic system is one of the key modulators of neuronal plasticity, and plays an important role in the control of "cr ...

Nature Research2016

Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism

Henry Markram, Julie Meystre, Deborah La Mendola, Kamila Markram, Mônica Regina Favre, Melissa Cochrane, Dimitri Marco Christodoulou

Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and pr ...

Frontiers Research Foundation2015

Modeling Immersive Media Experiences by Sensing Impact on Subjects

Touradj Ebrahimi, Philippe Hanhart, Martin Rerabek, Jong Seok Lee, Eleni Kroupi

As immersive technologies target to provide higher quality of multimedia experiences, it is important to understand the quality of experience (QoE) perceived by users from various multimedia rendering schemes, in order to design and optimize human-centric ...

Springer Verlag2016

The intense world syndrome – an alternative hypothesis for autism

Henry Markram, Kamila Markram, Tania Rinaldi

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007