Publications associées à Automobile

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unpre ...

Nature Portfolio2024

Cycling Interaction Rituals in the Conflict against the Car. From the Bike Subculture to the City Scale and Beyond

Alexandre André Robert Rigal

Mobility scholars have long been interested in challenging the automobile's hegemony in the street, particularly by highlighting how to develop urban cycling. The article contributes to this task by explaining how one type of conflict between the bike and ...

Taylor & Francis Ltd2023

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Angela Madurga Alonso

The use of CAR technologies has revolutionized cancer treatment. Their unprecedented efficacy against B cell malignancies has opened the doors for a lot of excitement and research in the field. These synthetic receptors are composed of an antigen recogniti ...

EPFL2023

Optimizing the utilization of existing vehicle flows in last-mile passenger transport and logistics systems

Patrick Stefan Adriaan Stokkink

The new era of shared economy has raised our expectations to make mobility more sustainable through better utilization of existing resources and capacity. In this thesis, we focus on the design of transport systems that stimulate multi-purpose trips with t ...

EPFL2023

Demand-based operations of vehicle sharing systems

Selin Ataç

Vehicle sharing systems (VSSs) allow users to rent vehicles for a short period of time, in a more flexible and convenient manner compared to the traditional vehicle rental services. The long-term VSS subscription replaces the need for contract signing for ...

EPFL2023

A general framework to evaluate different rebalancing operations strategies in one-way car sharing systems

Michel Bierlaire, Nikola Obrenovic, Selin Ataç

Car sharing systems (CSSs) are one of the environmentally beneficial solutions in urban transportation. However, the operators still struggle to make these systems profitable. One of the main contributors in operational cost is rebalancing operations. Ther ...

2022

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

Mathieu Girardin

Chimeric antigen receptors (CARs) are synthetic, transmembrane proteins that trigger immune cell signaling following their engagement. They have been first utilized in T cells and later in natural killer (NK) cells to redirect their cytotoxicity toward a s ...

EPFL2023

A hybrid microscopic model for multimodal traffic with empirical observations from aerial footage

Nikolaos Geroliminis, Georgios Anagnostopoulos

Microscopic traffic flow models can be distinguished in lane-based or lane-free depending on the degree of lane-discipline. This distinction holds true only if motorcycles are neglected in lane-based traffic. In cities, as opposed to highways, this is an o ...

2023

The rationales that underlie modal practices

Vincent Kaufmann

Encouraging a modal shift from individual transportation to less polluting modes such as public transport, walking and cycling, is now a key recommendation of the UN to reach the goals set by the Paris Agreement. Achieving this ambitious goal requires a de ...

2022

On the Insecurity of Vehicles Against Protocol-Level Bluetooth Threats

Mathias Josef Payer, Daniele Antonioli

Cars are some of the most security-critical consumer devices. On the one hand, owners expect rich infotainment features, including audio, hands-free calls, contact management, or navigation through their connected mobile phone. On the other hand, the infot ...

IEEE COMPUTER SOC2022

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Sailan Shui

Synthetic biology aims to engineer cells as miniature biological devices to sense, process, and respond to exogenous stimuli. Protein switches are designed to sense and respond to various molecular queues in a fast and specific manner, which fits the requi ...

EPFL2022

Optimization of operational decisions for on-demand shared mobility systems

Martin Jean Marie Joseph Repoux

This thesis introduces new operational management policies for two types of on-demand shared mobility systems, the now well-studied one-way carsharing systems and a new innovative semi-autonomous last-mile transportation system. In addition, two associated ...

EPFL2021

Predictive user-based relocation through incentives in one-way car-sharing systems

Nikolaos Geroliminis, Patrick Stefan Adriaan Stokkink

Car-sharing systems are an attractive alternative to private vehicles due to their benefits in terms of mobility and sustainability. However, the distribution of vehicles throughout the network in one-way systems is disturbed due to asymmetry and stochasti ...

2021

Understanding multimodality through rhythm of life. An empirical evidence from the Swiss case study

Alexis Gumy, Guillaume Simon Joseph Drevon

The car dominance car in the urban transport system may contribute to health and environmental troubles. In recent years, multimodality appears as a central issue for public policies as they try to encourage and develop the modal shift in favour of walking ...

Routledge2020

The dynamics of modal shifts in (sub)urban commuting: An empirical analysis based on practice theories

Claudia Rebeca Binder Signer, Franziska Meinherz

A modal shift away from the private car onto low-carbon transport modes is an essential part of decarbonising the transport sector. The dynamics of modal shifts are, however, not yet well understood. In particular the interrelations between structural and ...

2020

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Jaume Bonet Martinez, Pablo Gainza Cirauqui, Sabrina Susan Vollers, Sailan Shui

The activity of CAR-T cells is reversibly halted with a small-molecule drug. Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the s ...

2020

Individual changes in the bicycle community workshops, A typology from a new agent of socialization

Alexandre André Robert Rigal

Social change is at the center of solutions to the problems of the environment. Yet social change is sometimes elusively described. Through empirical inquiries guided by socialization theories, the present article aims to identify different types of indivi ...

2020

An optimization framework for exclusive bus lane allocation in large networks with dynamic congestion

Nikolaos Geroliminis, Dimitrios Tsitsokas, Anastasios Kouvelas

Road space distribution among multiple modes of transport in urban networks has attracted the interest of several researchers and policy planners. Traditionally, these problems are solved by ignoring operational and dynamic characteristics of multi-modal c ...

2019

Towards Mobility-as-a-Service: a cross-case analysis of public authorities' roles in the development of ICT-supported integrated mobility schemes

Maxime Ugo Julien Audouin

Automobiles have become counter-productive. Negative externalities resulting from car use have overcome the social benefits automobiles brought when initially introduced. Having shaped most contemporary transportation systems, the automobility regime is kn ...

EPFL2019

An optimization framework for a light electric vehicle sharing system

Michel Bierlaire, Nikola Obrenovic, Selin Ataç

The vehicle sharing systems (VSSs) are becoming more and more popular due to both financial and environmental effects. On the other hand, they face many challenges, such as inventory management of the vehicles and parking spots, imbalance of the vehicles, ...

2019