Publications associées à Gene–environment correlation

Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort

Jacques Fellay, Christian Axel Wandall Thorball

Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic risk scores (PRS) in the prediction of pre-transplant T2DM and post-transplant diabetes mellitus ( ...

Frontiers Media Sa2023

Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study

Jacques Fellay, Christian Axel Wandall Thorball

An individual polygenic risk score was associated with osteoporosis in people living with HIV. The genetic effect was robust, as it persisted after multivariable adjustment for established traditional and HIV-related osteoporosis risk factors, including te ...

OXFORD UNIV PRESS INC2023

Synthesis of near-diffraction-free orbital-angular-momentum space-time wave packets having a controllable group velocity using a frequency comb

Tobias Kippenberg, Maxim Karpov, Zhe Zhao, Hao Song, Xinzhou Su

Novel forms of light beams carrying orbital angular momentum (OAM) have recently gained interest, especially due to some of their intriguing propagation features. Here, we experimentally demonstrate the generation of near-diffraction-free two-dimensional ( ...

Optica Publishing Group2022

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores

Jacques Fellay, Christian Axel Wandall Thorball

Background In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m(2) per year for >= 3 ...

OXFORD UNIV PRESS INC2021

Gene-by-environment modulation of lifespan and weight gain in the murine BXD family

Johan Auwerx, Maroun Bou Sleiman, Evan Graehl Williams, Pooja Jha

How lifespan and body weight vary as a function of diet and genetic differences is not well understood. Here we quantify the impact of differences in diet on lifespan in a genetically diverse family of female mice, split into matched isogenic cohorts fed a ...

NATURE PORTFOLIO2021

Spatial areas of genotype probability: Predicting the spatial distribution of adaptive genetic variants under future climatic conditions

Stéphane Joost, Oliver Michele Selmoni, Estelle Rochat

In a context of rapid global change, one of the key components for the survival of species is their genetic evolutionary potential for adaptation. Many methods have been developed to identify genetic variants underpinning adaptation to climate, but few too ...

2021

Contribution of Genetic Background and Data Collection on Adverse Events of Anti-human Immunodeficiency Virus (HIV) Drugs (D:A:D) Clinical Risk Score to Chronic Kidney Disease in Swiss HIV-infected Persons With Normal Baseline Estimated Glomerular Filtration Rate

Jacques Fellay, Christian Axel Wandall Thorball

Background. In human immunodeficiency virus (HIV), the relative contribution of genetic background, clinical risk factors, and antiretrovirals to chronic kidney disease (CKD) is unknown. ...

OXFORD UNIV PRESS INC2020

Adapt or Perish: Evolutionary Rescue in a Gradually Deteriorating Environment

Anne-Florence Raphaëlle Bitbol, Loïc Marrec

We investigate the evolutionary rescue of a microbial population in a gradually deteriorating environment, through a combination of analytical calculations and stochastic simulations. We consider a population destined for extinction in the absence of mutan ...

2020

Rapid Recalibration of Peri-Personal Space: Psychophysical, Electrophysiological, and Neural Network Modeling Evidence

Olaf Blanke, Bruno Herbelin, Tommaso Enrico Bertoni, Andrea Serino, Jean-Paul Noel, Elisa Pellencin

Interactions between individuals and the environment occur within the peri-personal space (PPS). The encoding of this space plastically adapts to bodily constraints and stimuli features. However, these remapping effects have not been demonstrated on an ada ...

2020

Polygenic modelling of treatment effect heterogeneity

Zhi Ming Xu

Mendelian randomization is the use of genetic variants to assess the effect of intervening on a risk factor using observational data. We consider the scenario in which there is a pharmacomimetic (i.e., treatment-mimicking) genetic variant that can be used ...

2020

Rapid identification and interpretation of gene‐environment associations using the new R.SamBada landscape genomics pipeline

Stéphane Joost, Oliver Michele Selmoni, Estelle Rochat, Sylvie Stucki, Kevin Leempoel, Elia Vajana, Solange Catherine Gaillard

Samβada is a genome‐environment association (GEA) software, designed to search for signatures of local adaptation. However, pre‐ and post‐processing of data can be labour‐intensive, preventing wider uptake of the method. We have now developed R.SamBada, an ...

2019

Peripersonal space (PPS) as a multisensory interface between the individual and the environment, defining the space of the self

Andrea Serino

Our brain has developed a specific system to represent the space closely surrounding the body, termed pen personal space (PPS). This space has a key functional role as it is where all physical interactions with objects in the environment occur. Here I desc ...

PERGAMON-ELSEVIER SCIENCE LTD2019

The individual structure of visual space

Michael Herzog, Aline Françoise Cretenoud, Gregory Francis, Lukasz Grzeczkowski, Albulena Jashari-Shaqiri

Common factors are ubiquitous. First, we show that, however in vision, correlations of performance in similar paradigms are low even though test-retest reliability is high. Second, one might expect that correlations increase with increasing age because of ...

2018

Environmental heterogeneity promotes spatial resilience of phototrophic biofilms in streambeds

Andrea Rinaldo, Tom Ian Battin, Hannes Markus Peter, Enrico Bertuzzo, Mário Jorge Rodrigues Pereira Da Franca, Carmelo Juez Jiménez

The loss of environmental heterogeneity threatens biodiversity and ecosystem functioning. It is therefore important to understand the relationship between environmental heterogeneity and spatial resilience as the capacity of ecological communities embedded ...

2018

Neural adaptation accounts for the dynamic resizing of peripersonal space: evidence from a psychophysical-computational approach

Olaf Blanke, Andrea Serino, Jean-Paul Noel

Interactions between the body and the environment occur within the peripersonal space (PPS), the space immediately surrounding the body. The PPS is encoded by multisensory (audio-tactile, visual-tactile) neurons that possess receptive fields (RFs) anchored ...

2018

Check Out This Place: Inferring Ambiance from Airbnb Photos

Daniel Gatica-Perez, Laurent Son Nguyen

Airbnb is changing the landscape of the hospitality industry. For guests, the process of selecting a place to stay is a type of zero-acquaintance situation, and to this day little is known about the inferences that guests make about Airbnb listings. Enviro ...

2018

High performance computation of landscape genomic models including local indicators of spatial association

Stéphane Joost, Sylvie Stucki, Pierre Taberlet, Solange Catherine Gaillard

With the increasing availability of both molecular and topo-climatic data, the main challenges facing landscape genomics — i.e. the combination of landscape ecology with population genomics — include processing large numbers of models and distinguishing be ...

Wiley-Blackwell2017

Persistence of butterfly populations in fragmented habitats along urban density gradients: motility helps

Stéphane Joost, Estelle Rochat, Ivo Widmer

In a simulation study of genotypes conducted over 100 generations for more than 1600 butterfly’s individuals, we evaluate how the increase of anthropogenic fragmentation and reduction of habitat size along urbanisation gradients (from 7% to 59% of impervio ...

Nature Publishing Group2017

Experimental evolution of slowed cognitive aging in Drosophila melanogaster

Brian Dennis Hollis

Reproductive output and cognitive performance decline in parallel during aging, but it is unknown whether this reflects a shared genetic architecture or merely the declining force of natural selection acting independently on both traits. We used experiment ...

2017

Simple rules for an efficient use of Geographic Information Systems in molecular ecology

Stéphane Joost, Estelle Rochat, Kevin Leempoel, Ivo Widmer, Solange Catherine Gaillard

Geographic Information Systems (GIS) are becoming increasingly popular in the context of molecular ecology and conservation biology thanks to their display options efficiency, flexibility and management of geodata. Indeed, spatial data for wildlife and liv ...

2017