Publications associées à Impulsivité

Reward timing matters in motor learning

Pierre Theopistos Vassiliadis, Julie Duqué

Reward timing, that is, the delay after which reward is delivered following an action is known to strongly influence reinforcement learning. Here, we asked if reward timing could also modulate how people learn and consolidate new motor skills. In 60 health ...

CELL PRESS2022

Dopamine Transporter, PhosphoSerine129 alpha-Synuclein and alpha-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice

Salvatore Novello, Chiara Domenicale

The G2019S mutation in leucine rich-repeat kinase 2 (LRRK2) is a major cause of familial Parkinson's disease. We previously reported that G2019S knock-in mice manifest dopamine transporter dysfunction and phosphoSerine129 alpha-synuclein (pSer129 alpha-syn ...

MDPI2022

Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Xavier Fernandez-Real Girona

Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. ...

BMJ PUBLISHING GROUP2021

Amplified engagement of prefrontal cortex during control of voluntary action in Tourette syndrome

Sophie Jacqueline Andrée Betka

Tourette syndrome is characterized by 'unvoluntary' tics, which are compulsive, yet often temporarily suppressible. The inferior frontal gyms is implicated in motor control, including inhibition of pre-potent actions through influences on downstream subcor ...

OXFORD UNIV PRESS2020

Frontal cortical thickness correlates positively with impulsivity in early psychosis male patients

Alessandra Griffa, Kim Do

Aim Impulsive behaviours, which are frequent in young people suffering from psychosis have been linked to risky and violent behaviours and participate to the burden of psychotic illness. Given that morphological brain correlates of impulsivity in schizophr ...

WILEY2019

Latency to Reward Predicts Social Dominance in Rats: A Causal Role for the Dopaminergic Mesolimbic System

Maria del Carmen Sandi Perez, Simone Astori, Ioannis Zalachoras, Laura Lozano Montes, Sonia Abad Florensa

Reward signals encoded in the mesolimbic dopaminergic system guide approach/seeking behaviors to all varieties of life-supporting stimuli (rewards). Differences in dopamine (DA) levels have been found between dominant and submissive animals. However, it is ...

2019

Long term programming of psychopathology-like behaviors in male rats by peripubertal stress depends on individual’s glucocorticoid responsiveness to stress

Maria del Carmen Sandi Perez, Sophie Elizabeth Walker

Experience of adversity early in life and dysregulation of hypothalamus–pituitary–adrenocortical (HPA) axis activity are risk factors often independently associated with the development of psychopathological disorders, including depression, PTSD and pathol ...

2018

Stress, glucocorticoid receptor and social behaviors

Peripuberty, comprising childhood and adolescence, constitutes an important time window in the brain development and maturation. Exposure to prolonged stress during this period has been shown to increase the risk for the development of psychopathologies la ...

EPFL2017

In vivo neurochemistry of the ventral striatum and social competition in Homo sapiens

Alina Veronika Irene Strasser

Ventral striatal function and trait anxiety have been shown to influence reward-seeking behaviour and social competition in humans. Moreover, social status perceptions have been shown to modulate ventral striatal function. The neurochemical underpinnings o ...

EPFL2017

Sustained enhancements in inhibitory control depend primarily on the reinforcement of fronto-basal anatomical connectivity

Wietske Van der Zwaag, Bogdan Draganski, Michaël Mouthon

What are the neurophysiological determinants of sustained supra-normal inhibitory control performance? We addressed this question by coupling multimodal neuroimaging and behavioral investigations of experts in fencing who underwent more than 20,000 h of in ...

Springer Heidelberg2017

Neuroligin-2 expression in the prefrontal cortex is involved in attention deficits induced by peripubertal stress

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht

Emerging evidence indicates that attention deficits, which are frequently observed as core symptoms of neuropsychiatric disorders, may be elicited by early life stress. However, the mechanisms mediating these stress effects remain unknown. The prefrontal c ...

2016

Pro Free Will Priming Enhances "Risk-Taking" Behavior in the Iowa Gambling Task, but Not in the Balloon Analogue Risk Task: Two Independent Priming Studies

Christine Mohr, Noé Thomas Elie Ohana, Alessandro Tremea

Studies indicated that people behave less responsibly after exposure to information containing deterministic statements as compared to free will statements or neutral statements. Thus, deterministic primes should lead to enhanced risk-taking behavior. We t ...

Public Library Science2016

Impaired spatial working memory after anterior thalamic lesions: recovery with cerebrolysin and enrichment

Guillaume Poirier

Lesions to the anterior thalamic nuclei (ATN) in rats produce robust spatial memory deficits that reflect their influence as part of an extended hippocampal system. Recovery of spatial working memory after ATN lesions was examined using a 30-day administra ...

Springer Heidelberg2016

The impact of anxiety and reward-seeking traits on social competition and the role of the mesolimbic dopaminergic system

Laura Lozano Montes

Social hierarchies are established across a range of different taxa in the animal kingdom. Given that hierarchy inequalities are highly present in nowadays society and the health problems that low rank individuals suffer from this, it is surprising that no ...

EPFL2015

The effects of extrinsic stress on somatic markers and behavior are dependent on animal housing conditions

Maria del Carmen Sandi Perez, Guillaume Poirier, Michael van der Kooij, Damien Sébastien Huzard

Properties of the environment play an important role in animal wellbeing and may modulate the effects of external threats. Whereas stressors can affect emotion and impair cognition, environmental enrichment may prevent the occurrence of such negative seque ...

Pergamon-Elsevier Science Ltd2015

Effects of High Angular Momentum on the Unimolecular Dissociation of CD2CD2OH: Theory and Comparisons with Experiment

Michele Ceriotti

This paper explores the dynamics of a highly rotationally and vibrationally excited radical, CD2CD2OH. The radical is produced from the 193 nm photodissociation of 2-bromoethanol-d(4), so it is imparted with high angular momentum and high vibrational energ ...

American Chemical Society2013

Visual backward masking deficits in schizophrenic patients are associated with polymorphisms in the nicotinic receptor α7 subunit gene (CHRNA7)

Michael Herzog, Maya Roinishvili

Visual backward masking (BM) deficits are often proposed to be trait markers for schizophrenia revealing the genetic underpinnings of the disease. Here, we show that, indeed, masking deficits in the shine-through effect are associated with polymorphisms in ...

2010

Encoding of Marginal Utility across Time in the Human Brain

Marginal utility theory prescribes the relationship between the objective property of the magnitude of rewards and their subjective value. Despite its pervasive influence, however, there is remarkably little direct empirical evidence for such a theory of v ...

2009

The Neurobiological Foundations of Valuation in Human Decision Making under Uncertainty

This chapter focuses on valuation in the context of choice under uncertainty. When valuation is a pursuit distinct from choice, values revealed through choice may be different from the valuations that emerge from the (choice-independent) computations. In m ...

Academic Press2009