Publications associées à Sénescence

Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years

Jacques Fellay, Christian Axel Wandall Thorball

Background Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term comparison of epigenetic ageing dynamics in people with HIV during untreated ...

ELSEVIER2023

Detecting the metabolism of individual yeast mutant strain cells when aged, stressed or treated with antioxidants with diamond magnetometry

Mayeul Sylvain Chipaux

Free radicals play a key role in the ageing process. However, free radicals are small, reactive and short lived and thus challenging to measure. We utilize a new technique called diamond magnetometry for this pur-pose. We make use of nitrogen vacancy cente ...

ELSEVIER SCI LTD2023

Predictive health assessment for lithium-ion batteries with probabilistic degradation prediction and accelerating aging detection

Florent Evariste Forest, Yunhong Che

Predictive health assessment is of vital importance for smarter battery management to ensure optimal and safe operations and thus make the most use of battery life. This paper proposes a general framework for battery aging prognostics in order to provide t ...

Elsevier Sci Ltd2023

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

Maria Brbic, Sandy Lee

Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila. We c ...

American Association for the Advancement of Science2023

Telomere protection against oxidative stress

Thu Trang Nguyen

Telomeres are nucleoprotein structures at the ends of linear chromosomes, being essential for the maintenance of genomic integrity. Telomeres have a unique structure which distinguishes chromosome termini from DNA damage sites. Shelterin complexes are the ...

EPFL2023

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Yang Zhao

CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...

EPFL2023

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Johan Auwerx, Xiaoxu Li, Mario Romani, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Hao Li, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Dohyun Park, Barbara Moreira Crisol, Changmyung Oh, Jean-David Horacio Morel

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

AMER ASSOC ADVANCEMENT SCIENCE2023

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Patrick Descombes, Jérome Feige, Sylviane Métairon, Omid Mashinchian, Filippo De Franceschi, Nicolas Bouche, Christophe Boss

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Johan Auwerx, Kristina Schoonjans, Felix Naef, Xiaoxu Li, Jia Liu, Hao Li, Wen Gao, Nagammal Neelagandan, Yang Li, Amélia Lalou, Yuan Liu

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Richardus Houtkooper, Wen Gao, Yuan Liu

Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...

Nature Portfolio2022

cGAS regulation and activity during genotoxic stress

Sélène-Véronique Glück

The innate immune system has evolved to detect pathogens through germlineencoded pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class of PRRs, bind to microbial and viral nucleic acids and trigger the production of type I interferons ...

EPFL2020

Basic creep of cement paste at early age - the role of cement hydration

Karen Scrivener, Pietro Lura

In this work, the uniaxial creep in compression during the first days of hydration is studied experimentally on cement pastes with w/c of 0.50. to order to assess the effect of the evolving microstructure on creep, the so-called equivalent systems are empl ...

Pergamon-Elsevier Science Ltd2019

Cross-species functional modules link proteostasis to human normal aging

Johan Auwerx, Hao Li, Vincenzo Sorrentino, Andrea Komljenovic

The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a com ...

2019

Protocol for the PreventIT feasibility randomised controlled trial of a lifestyle-integrated exercise intervention in young older adults

Kamiar Aminian, Anisoara Ionescu

Introduction The European population is rapidly ageing. In order to handle substantial future challenges in the healthcare system, we need to shift focus from treatment towards health promotion. The PreventIT project has adapted the Lifestyle-integrated Ex ...

BMJ2019

Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle

Tanja Sonntag

The progressive decline of muscle mass and function called sarcopenia is a multi-factorial process associated to frailty, disability, and low quality of life in the elderly. The co-factor nicotinamide adenine dinucleotide (NAD+) becomes a limiting factor i ...

EPFL2019

Evolution of longevity improves immunity in Drosophila

Bruno Lemaitre

Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin ...

JOHN WILEY & SONS LTD2018

Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape

Georg Fantner, John McKinney, Haig Alexander Eskandarian

In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L,D-transpeptidases (LDTs) are highly abundant. To elucidate the role of these unusual cr ...

ELIFE SCIENCES PUBLICATIONS LTD2018

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

Johan Auwerx, Xu Wang

Mitochondrial function is controlled by two separate genomes. This feature makes mitochondria prone to proteotoxic stress when a stoichiometric imbalance occurs in the protein complexes that perform oxidative phosphorylation, which consist of both nucleara ...

Cell Press2017

Agents and methods using thereof for the prevention and treatment of stem cells senescence

Johan Auwerx, Dongryeol Ryu, Hongbo Zhang, Keir Joe Menzies

The present invention relates to agents that prevent or reverse process of stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of stem senescence. ...

2017

Predicting the Success of Online Petitions Leveraging Multidimensional Time-Series

Karl Aberer, Philippe Cudré-Mauroux, Julia Proskurnia, Carlos Castillo

Applying classical time-series analysis techniques to online content is challenging, as web data tends to have data quality issues and is often incomplete, noisy, or poorly aligned. In this paper, we tackle the problem of predicting the evolution of a time ...