Concept

Modèle diathèse–stress

Publications associées (28)

Long‑term strain measurements of traffic and temperature effects on an RC bridge deck slab strengthened with an R‑UHPFRC layer

Eugen Brühwiler, Bartlomiej Wojciech Sawicki

This paper presents the results of 28-month-long monitoring of a slab portion of the Chillon viaducts in Switzerland using strain gauges and thermocouples. This post-tensioned reinforced concrete structure was strengthened with a layer of reinforced ultrah ...

2020

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

Rolf Gruetter, Maria del Carmen Sandi Perez, Jocelin Grosse, João Pedro de Matos Rodrigues, Antoine Timothée Cherix, Thomas Didier Larrieu

Emerging evidence suggests that hierarchical status provide vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus accumbens (NAc) were recently related to hierarchical status and vulnerability to develop depression-lik ...

2020

Experimental studies of hydro-mechanical couplings in Enhanced Geothermal Reservoirs

Mateo Alejandro Acosta

Enhanced Geothermal Systems (EGS) allow for worldwide geothermal electricity production. They target deep (3-5 km), fractured rock reservoirs whose permeability is artificially increased through hydraulic stimulations (fluid injections). The injections mod ...

EPFL2020

Pituitary dysmaturation affects psychopathology and neurodevelopment in 22q11.2 Deletion Syndrome

Dimitri Nestor Alice Van De Ville, Maria del Carmen Sandi Perez, Maude Schneider, Marie Schaer, Daniela Maria Zöller, Maëlle Chambaz

Background 22q11.2 Deletion Syndrome (22q11DS) confers strongly increased genetic risk for multiple psychiatric disorders. Similarly to the general population, rates of psychiatric comorbidity suggest that common disease mechanisms are shared across dimens ...

2020

Hydro-mechanical behaviour of shallow Opalinus Clay shale

Lyesse Laloui, Alessio Ferrari, Eleonora Crisci

In Switzerland, Opalinus Clay shale has been selected as the host formation for radioactive waste disposal. The minimum required depth of the repository is related to the long-lasting isolation required for the disposal (1 million years). During this perio ...

2019

Anisotropic behaviour of shallow opalinus clay

Lyesse Laloui, Alessio Ferrari, Eleonora Crisci, Alberto Minardi

Opalinus Clay shale, the selected host geomaterial of a high-level radioactive waste repository in Switzerland, was sourced at shallow depth in a borehole in the northern part of the country. Pairs of specimens, retrieved from the same depth were prepared ...

Springer Verlag2019

Effects of spatial variation of cluster entry friction on hydraulic fracture propagation in multistage fracturing

Brice Tanguy Alphonse Lecampion, Dmitry Nikolskiy

In this contribution, we explore different aspects of the multi-stage fracturing process such as stress interaction between growing hydraulic fractures, perforation and near-wellbore tortuosity effects as well as the wellbore flow dynamics using a fit-for- ...

2019

Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology

Maria del Carmen Sandi Perez, Hilal Lashuel, Johannes Burtscher, Anass Chiki, João Pedro de Matos Rodrigues, Jean-Christophe Copin

Debilitating, yet underinvestigated nonmotor symptoms related to mood/emotion, such as depression, are common in Parkinson's disease. Here, we explore the role of depression and of the amygdala, a brain region robustly linked to mood/emotion, in synucleino ...

2019