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Publications associées (28)

CDK4 Phosphorylates AMPK alpha 2 to Inhibit Its Activity and Repress Fatty Acid Oxidation

Anita Nasrallah, Caterina Collodet, Judit Castillo Armengol

The roles of CDK4 in the cell cycle have been extensively studied, but less is known about the mechanisms underlying the metabolic regulation by CDK4. Here, we report that CDK4 promotes anaerobic glycolysis and represses fatty acid oxidation in mouse embry ...

Cell Press2017

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Etienne Meylan, Nadine Fournier, Miguel Garcia, Alessandra Piersigilli, Julien Robert Rémi Faget, Inti Zlobec, Gael Luis Boivin, Svenja Johanna Groeneveld, Loïc Steiner, Ioannis Xenarios

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

In vivo cerebral metabolism of glioblastoma xenografts assessed with ¹H MRS, ¹³C MRS and ¹⁸F-FDG PET

Marta Lai

Magnetic resonance spectroscopy (MRS) is a powerful tool when studying metabolism in intact and living organs preserving cells in their natural microenvironment with minimal external interference. The unique insights offered by the observation of metabolic ...

EPFL2017

ATP and NADPH coated iron oxide nanoparticles for targeting of highly metabolic tumor cells

Dominique Bonvin, Heinrich Hofmann

The metabolic activity of tumor cells is known to be higher as compared to that of normal cells, which has been previously exploited to deliver nanomedicines to highly metabolic tumor cells. Unfortunately, current strategies, which are mostly based on comp ...

Royal Society of Chemistry2017

Study of cortical energy metabolism during sensory stimulation-induced brain activity by ¹³C magnetic resonance spectroscopy in vivo

Sarah Catherine Sonnay

Cerebral function is associated with high metabolic activity that is supported by continuous supply of oxygen and glucose from the blood. Coupling between brain energy metabolism and neuronal activity has been studied extensively during the past decades. N ...

EPFL2017

AMPK alpha 1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Lin Yang, Kei Sakamoto, Caterina Collodet, Laurent Bultot

Control of stem cell fate to either enter terminal differentiation versus returning to quiescence (self-renewal) is crucial for tissue repair. Here, we showed that AMP-activated protein kinase (AMPK), the master metabolic regulator of the cell, controls mu ...

Wiley2017

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Olivier Michielin, Etienne Meylan, Paolo Angelino, Mauro Delorenzi, Jessica Christine Vazquez, Pierre-Benoit Bernard Ancey, Stefania Crippa

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. W ...

2017

Deciphering the Role of LRH-1 in Liver Intermediary Metabolism and Cancer

Pan Xu

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Gaining insight into the molecular pathways involved in the development of HCC is hence a prerequisite to design and develop novel and effective therapeutic strategies. ...

EPFL2016

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