Publications associées à Dose létale médiane

Hydrogenated amorphous silicon high flux x-ray detectors for synchrotron microbeam radiation therapy

Sylvain Dunand, Nicolas Würsch, Matthew James Large, Giulia Rossi

Objective. Microbeam radiation therapy (MRT) is an alternative emerging radiotherapy treatment modality which has demonstrated effective radioresistant tumour control while sparing surrounding healthy tissue in preclinical trials. This apparent selectivity ...

IOP Publishing Ltd2023

Development and applications of hyperpolarized 13C and 1H MR spectroscopy of cerebral metabolism at ultra-high field

Emmanuelle Ines Flatt

This thesis is composed of four studies centered on investigating cerebral metabolism using magnetic resonance spectroscopy (MRS) of hyperpolarized and non-hyperpolarized compounds at ultra-high field. In the first two chapters, we studied longitudinally t ...

EPFL2021

Satellite-Based Personal UV Dose Estimation

Athanasios Nenes, David Vernez

Epidemiology and public health research relating to solar ultraviolet (UV) exposure usually relies on dosimetry to measure UV doses received by individuals. However, measurement errors affect each dosimetry measurement by unknown amounts, complicating the ...

2021

Impact of the skull contour definition on Leksell Gamma Knife(R)Icon (TM) radiosurgery treatment planning

Constantin Tuleasca

Introduction The Gamma Knife(R)planning software (TMR 10, Elekta Instruments, AB, Sweden) affords two ways of defining the skull volume, the "historical" one using manual measurements (still perform in some centers) and the new one using image-based skull ...

2020

Volatile organic compounds in 169 energy-efficient dwellings in Switzerland

Dusan Licina, Shen Yang

Exposure to elevated levels of certain volatile organic compounds (VOCs) in households has been linked to deleterious health effects. This study presents the first large-scale investigation of VOC levels in 169 energy-efficient dwellings in Switzerland. Th ...

2020

A fish intestinal barrier model to assess the interaction with chemicals in vitro

Hannah Inka Schug

The intestinal epithelium acts as vital gate keeper between the fish and its surrounding environment. A single layer of connected epithelial cells forms a selective barrier, which, among other essential functions, is important for nutrient uptake and defen ...

EPFL2019

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Johan Auwerx, Patrick Aebischer, Pénélope Andreux, Dongryeol Ryu, Frederic Burdet, Anurag Singh

Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging(1). Here, we report the results of a first-in-human clinical trial in which we adm ...

NATURE PUBLISHING GROUP2019

TransFEr: a new device to measure the transfer of volatile and hydrophobic organic chemicals across an in vitro intestinal fish cell barrier

Kristin Schirmer, Hannah Inka Schug

Transfer of compounds across cellular barriers is a critical step of compound uptake into organisms. Using in vitro barrier systems to evaluate such transfer is attractive because of the higher throughput and reduced resource needs compared to animal studi ...

ROYAL SOC CHEMISTRY2018

On the origin of primary 1/2 a(0) and a(0) loops in irradiated Fe(Cr) alloys

Robin Schäublin, Anna Prokhodtseva

The radiation-induced primary dislocation loops in thin foils of ultra-high purity Fe and Fe(Cr) model alloys were investigated using ion irradiation in situ in a TEM. In the '111 mechanism' the induced nanometric loops of type a(0) stem from mutual ...

Pergamon-Elsevier Science Ltd2017

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

John McKinney, Neeraj Dhar, François Signorino-Gelo

Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of ison ...

Elsevier Science Bv2016

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique w ...

2015

Investigating Alternatives To The Fish Early-Life Stage Test: A Strategy For Discovering And Annotating Adverse Outcome Pathways For Early Fish Development

Kristin Schirmer

The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical manag ...

Wiley-Blackwell2014

Modelling oriented investigations of primary radiation damage in ultra high purity Fe and FeCr alloys

Anna Prokhodtseva

In the quest of the structural materials for the future fusion reactor, it has been shown that ferritic/martensitic (F/M) steels are very promising candidates, with a good radiation resistance in terms of damage accumulation in the microstructure relative ...

EPFL2013

The Insecticide Imidacloprid Causes Mortality of the Freshwater Amphipod Gammarus pulex by Interfering with Feeding Behavior

Kristin Schirmer

If an organism does not feed, it dies of starvation. Even though some insecticides which are used to control pests in agriculture can interfere with feeding behavior of insects and other invertebrates, the link from chemical exposure via affected feeding a ...

Public Library Science2013

Radiation damage in ferritic/martensitic steels for fusion reactors: a simulation point of view

Low activation ferritic/martensitic steels are good candidates for the future fusion reactors, for, relative to austenitic steels, their lower damage accumulation and moderate swelling under irradiation by the 14 MeV neutrons produced by the fusion reactio ...

IOP Publishing Ltd2007

Développement et validation de méthodes dosimétriques en ligne pour le traitement du cancer de la prostate

Currently, the treatment of prostate cancer under open MRI at the University of Geneva Hospital, applying high dose rate (HDR) brachytherapy, involves three main steps : needle implantation, dosimetric calculations and irradiation. As such, there is no pre ...

EPFL2005

144Ce as a potential candidate for interstitial and intravascular brachytherapy

Rakesh Chawla, François Bochud

To investigate the suitability of 144Ce for both interstitial and intravascular brachytherapy applications. Monte Carlo calculations of radial dose rate distributions in water were performed for 144Ce in a spring-shaped source and compared with two commonl ...

Elsevier2005