Publications associées à Grippe espagnole

Inactivation of influenza A virus in expiratory droplets and aerosol particles and the associated physicochemical drivers

Influenza is an infectious respiratory illness caused by influenza viruses. Every year, it causes up to one billion cases of disease worldwide. Despite its high disease burden, the transmission pathway of influenza remains subject to debate. There is incre ...

EPFL2024

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Alexis Joseph Proutière, Loriane Bader, Natalia Carolina Drebes Dorr, Milena Jadwiga Jaskolska

Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive behavior ...

2022

Electrochemical sensors for the detection of SARS-CoV-2 virus

Somanath Jagannath, Neeraj Kumar

Coronavirus (COVID-19), a deadly pandemic has spread worldwide and created many global health issues. Though methods of its detection are being continuously developed for the early detection and monitoring of COVID-19, still there is need for more novel me ...

ELSEVIER SCIENCE SA2022

Projected resurgence of COVID-19 in the United States in July-December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination

Francisco Javier Perez Saez, Shi Chen

In Spring 2021, the highly transmissible SARS-CoV-2 Delta variant began to cause increases in cases, hospitalizations, and deaths in parts of the United States. At the time, with slowed vaccination uptake, this novel variant was expected to increase the ri ...

eLIFE SCIENCES PUBL LTD2022

Wastewater monitoring outperforms case numbers as a tool to track COVID-19 incidence dynamics when test positivity rates are high

Tamar Kohn, Xavier Fernandez Cassi, Joseph Chadi Benoit Lemaitre, Federica Cariti, Alex Tunas Corzon, Timothy R. Julian, Carola Bänziger

Wastewater-based epidemiology (WBE) has been shown to coincide with, or anticipate, confirmed COVID-19 case numbers. During periods with high test positivity rates, however, case numbers may be underreported, whereas wastewater does not suffer from this li ...

2021

A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19

Henry Markram, Emmanuelle Logette, Samuel Claude Kerrien, Enrico Scantamburlo, Daniel Keller, Jay Coggan, Cyrille Pierre Henri Favreau, Francesco Casalegno, Mohameth François Sy, Anna-Kristin Kaufmann, Pierre-Alexandre Fonta, Marine Laure Bertschy

SARS-CoV-2 started spreading toward the end of 2019 causing COVID-19, a disease that reached pandemic proportions among the human population within months. The reasons for the spectrum of differences in the severity of the disease across the population, an ...

FRONTIERS MEDIA SA2021

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

Grégoire Michielin

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

EPFL2021

Switchover phenomenon induced by epidemic seeding on geometric networks

Gergely Odor

It is a fundamental question in disease modeling how the initial seeding of an epidemic, spreading over a network, determines its final outcome. One important goal has been to find the seed configuration, which infects the most individuals. Although the id ...

2021

Benjamin's Flu

Christophe van Gerrewey

Walter Benjamin suffered from the Spanish Flu, but he never wrote about this global pandemic. There are three possible reasons for this oblivion, and several consequences for architecture's relationship with the current virus dominating our thoughts and ac ...

2020

A digital reconstruction of the 1630–1631 large plague outbreak in Venice

Frédéric Kaplan, Marcel Salathé, Gianrocco Lazzari, Giovanni Colavizza

The plague, an infectious disease caused by the bacterium Yersinia pestis, is widely considered to be responsible for the most devastating and deadly pandemics in human history. Starting with the infamous Black Death, plague outbreaks are estimated to have ...

Nature Research2020

Photocatalytic degradation of binary and ternary mixtures of antibiotics: reactive species investigation in pilot scale

Sami Rtimi

The present study investigates the photocatalytic degradation of three quinolone antibiotics (i.e., Flumequine (FLU), Oxolinic Acid (OA) and Nalidixic Acid (NA)) in mono-, binary and ternary compound systems. The closed-loop step photo-reactor and TiO2 imp ...

INST CHEMICAL ENGINEERS2019

Virucidal nanomaterials against influenza

Özgün Kocabiyik

Influenza affects millions of people in all parts of the world. The fact that influenza virus can spread through air increases the chance of influenza outbreaks. There are 3 to 5 million severe cases of influenza resulting in 290,000 to 650,000 deaths ever ...

EPFL2019

Inactivation of waterborne viruses by ozone: Kinetics and mechanisms

Camille Wolf

The growing world population, in conjunction with climate change, cases the global water de-mand to increase. It is, therefore, crucial to protect existing water resources from chemical pollution and contamination by pathogens. An increasingly popular stra ...

EPFL2019

Discovery and Further Studies on Giant Viruses at the IHU Mediterranee Infection That Modified the Perception of the Virosphere

Meriem Bekliz

The history of giant viruses began in 2003 with the identification of Acanthamoeba polyphaga mimivirus. Since then, giant viruses of amoeba enlightened an unknown part of the viral world, and every discovery and characterization of a new giant virus modifi ...

MDPI2019

Assessing the Dynamics and Control of Droplet- and Aerosol-Transmitted Influenza Using an Indoor Positioning System

Marcel Salathé, Gianrocco Lazzari

There is increasing evidence that aerosol transmission is a major contributor to the spread of influenza. Despite this, virtually all studies assessing the dynamics and control of influenza assume that it is transmitted solely through direct contact and la ...

Nature Research2019

Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells

Christian Sieben

The 2009 influenza pandemic originated from a swine-origin H1N1 virus, which, although less pathogenic than anticipated, may acquire additional virulence-associated mutations in the future. To estimate the potential risk, we sequentially passaged the isola ...

Academic Press Inc Elsevier Science2016

Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment

Jeffrey David Jensen, Matthieu Foll

Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species barriers to potentially create highly virulent ...

Oxford University Press2015

Médecine génomique et Maladies infectieuses [Genomic medicine and infectious diseases]

Jacques Fellay

Les progrès actuels dans la connaissance des variations génétiques humaines et de leurs conséquences fonctionnelles permettent de mieux comprendre la bataille millénaire que se livrent l'homme et les microbes. De nombreux polymorphismes modulant notre répo ...

2014

Frequentist estimation of an epidemic's spreading potential when observations are scarce

Victor Panaretos, Andrea Kraus

We consider the problem of inferring the potential of an epidemic for escalating into a pandemic on the basis of limited observations in its initial stages. Classical results of Becker & Hasofer (J. R. Statist. Soc. B, 59, 415-29) illustrate that frequenti ...

Oxford University Press2014

Glucose- but Not Rice-Based Oral Rehydration Therapy Enhances the Production of Virulence Determinants in the Human Pathogen Vibrio cholerae

Andrea Rinaldo, Melanie Blokesch, Enrico Bertuzzo, Flavio Finger, Juliane Kühn, Marino Gatto

Despite major attempts to prevent cholera transmission, millions of people worldwide still must address this devastating disease. Cholera research has so far mainly focused on the causative agent, the bacterium Vibrio cholerae, or on disease treatment, but ...

2014