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Publications associées (31)

Mesoscopic population equations for spiking neural networks with synaptic short-term plasticity

Wulfram Gerstner, Tilo Schwalger, Valentin Marc Schmutz

Coarse-graining microscopic models of biological neural networks to obtain mesoscopic models of neural activities is an essential step towards multi-scale models of the brain. Here, we extend a recent theory for mesoscopic population dynamics with static s ...

2020

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

Jean-Philippe Thiran, Graham Knott, Maxime Descoteaux, Giorgio Innocenti, Tim Bjørn Dyrby

The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological ...

OXFORD UNIV PRESS INC2019

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

2019

Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Rodrigo de Campos Perin, Giuseppe Chindemi, Natali Barros Zulaica

Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...

2019

Mapping of real-time morphological changes in the neuronal cytoskeleton with label-free wide-field second-harmonic imaging: a case study of nocodazole

Sylvie Roke, Carlos Alberto Macias Romero, Pascal Jourdain, Marie Eve Pascale Didier, Claire Jacqueline Léa Teulon

We demonstrate the use of wide-field high-throughput second-harmonic (SH) microscopy for investigating cytoskeletal morphological changes on the single-cell level. The method allows for real-time, in vitro, label-free measurements of cytoskeletal changes t ...

SPIE-Intl Soc Optical Eng2019

Ultrastructural basis of strong unitary inhibition in a binaural neuron

Graham Knott, Ralf Schneggenburger, Enida Gjoni, Clémentine Léa Aguet

Binaural neurons in the lateral superior olive (LSO) integrate sound information arriving from each ear, and powerful glycinergic inhibition of these neurons plays an important role in this process. In the present study, we investigated the ultrastructural ...

WILEY2018

Upper stimulation threshold for retinal ganglion cell activation

Diego Ghezzi

Objective. The existence of an upper threshold in electrically stimulated retinal ganglion cells (RGCs) is of interest because of its relevance to the development of visual prosthetic devices, which are designed to restore partial sight to blind patients. ...

2018

Orientation-Dispersed Apparent Axon Diameter via Multi-Stage Spherical Mean Optimization

Jean-Philippe Thiran, Marco Pizzolato

The estimation of the apparent axon diameter (AAD) via diffusion MRI is affected by the incoherent alignment of single axons around its axon bundle direction, also known as orientational dispersion. The simultaneous estimation of AAD and dispersion is chal ...

SPRINGER-VERLAG BERLIN2018

Validation strategies for the interpretation of microstructure imaging using diffusion MRI

Giorgio Innocenti, Tim Bjørn Dyrby

Extracting microanatomical information beyond the image resolution of MRI would provide valuable tools for diagnostics and neuroscientific research. A number of mathematical models already suggest microstructural interpretations of diffusion MRI (dMRI) dat ...

2018

Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport

Andrea Volterra

The uptake of glutamate by synaptic vesicles is mediated by vesicular glutamate transporters (VGLUTs). The central role of these transporters in excitatory neurotransmission underpins their importance as pharmacological targets. Although several compounds ...

Amer Chemical Soc2017

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images

Graham Knott, Anne Alison Jorstad, Daniel Lebrecht

The ability to measure minute structural changes in neural circuits is essential for long-term in vivo imaging studies. Here, we propose a methodology for detection and measurement of structural changes in axonal boutons imaged with time-lapse two-photon l ...

Elife Sciences Publications Ltd2017

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