Publications associées à Interphase

Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning

Whole genome doubling (WGD) events are drivers of genetic innovation across vertebrate evolution. While generally detrimental to mammalian organisms, WGDs are crucial in the development of various plants and fungi, as well as for the terminal differentiati ...

EPFL2023

Pure Amorphous and Ultrathin Phosphate Layer with Superior Ionic Conduction for Zinc Anode Protection

Kangning Zhao

Fast and uniform ion transport within the solid electrolyte interphase (SEI) is considered a crucial factor for ensuring the long-term stability of metal electrodes. In this study, we present the fabrication of ultrathin artificial interphases consisting o ...

Amer Chemical Soc2023

Understanding JET-C quiescent phases with edge harmonic magnetohydrodynamic activity and comparison with behaviour under ITER-like wall conditioning

Wilfred Anthony Cooper, Jonathan Graves, Daniele Brunetti, Alberto Mariani, Andreas Kleiner, Guillermo Bustos Ramirez

An analysis of edge localised mode-free (quiescent) H-mode discharges exhibiting edge harmonic magnetoydrodynamic activity in the JET-carbon wall machine is presented. It is observed that the otherwise quiescent pulses with multiple-n harmonic oscillations ...

IOP Publishing Ltd2022

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

Patrik Aouad

Compared to estrogen receptor-negative (ER-) breast cancer (BC), ER+ BC often manifests with a latent disease that recurs decades after initial diagnosis. The mechanisms governing dormancy and distant recurrence of ER+ tumors remain elusive due to the lack ...

EPFL2021

The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

Torgil Elias Friman

Precise spatiotemporal regulation of gene expression is essential for development and homeostasis of complex organisms. This is achieved in large part by sequence-specific transcription factors (TF) that bind to genomic regulatory elements to activate or r ...

EPFL2019

Transcription-induced supercoiling explains formation of self-interacting chromatin domains in S-pombe

Yannis Burnier, Julien Dorier, Fabrizio Benedetti, Andrzej Stasiak

The question of how self-interacting chromatin domains in interphase chromosomes are structured and generated dominates current discussions on eukaryotic chromosomes. Numerical simulations using standard polymer models have been helpful in testing the vali ...

Oxford University Press (OUP)2017

Eukaryotic transcription factor binding kinetics : a single-molecule and functional study

Andrea Callegari

Transcription represents a key regulatory step in gene expression and transcription factors (TFs) are the key molecular players of this process. TFs inhibit or promote the assembly of the transcriptional machinery by binding DNA and several co-factors. Whe ...

EPFL2016

Aurora A kinase regulates proper spindle positioning in C-elegans and in human cells

Pierre Gönczy, Coralie Busso, Sachin Kotak

Accurate spindle positioning is essential for error-free cell division. The one-cell Caenorhabditis elegans embryo has proven instrumental for dissecting mechanisms governing spindle positioning. Despite important progress, how the cortical forces that act ...

2016

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

Suliana Manley, Aleksandr Benke, David Michael Suter, Marion Leleu, Andrea Callegari, Cédric Deluz, Torgil Elias Friman, Mahé Cécile Raccaud, Daniel Strebinger

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016

Models that include supercoiling of topological domains reproduce several known features of interphase chromosomes

Yannis Burnier, Julien Dorier, Fabrizio Benedetti, Andrzej Stasiak

Understanding the structure of interphase chromosomes is essential to elucidate regulatory mechanisms of gene expression. During recent years, high-throughput DNA sequencing expanded the power of chromosome conformation capture (3C) methods that provide in ...

Oxford University Press2014

The physics and micro-mechanics of nano-voids and nano-particles in polymer combinations

In this article the role of voids or particulate inclusions of different sizes on mechanical properties and particularly on toughness in several polymers is discussed. With decreasing void sizes and intervoid distances, the influence of the interphase mate ...

Elsevier Sci Ltd2013

Isolation and Analysis of Regulators Coordinating the Nuclear Cycle with Cytokinesis in Schizosaccharomyces Pombe

Evelyn Lattmann

During the division of a mother cell into two daughter cells the genetic material of the mother cell is replicated and segregated to the daughter cells before the cytoplasm divides into two portions in a process called cytokinesis. In order to maintain the ...

EPFL2012

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

The Plasmodium falciparum kinome includes a family of four protein kinases (Pfnek-1 to -4) related to the NIMA (never-in-mitosis) family, members of which play important roles in mitosis and meiosis in eukaryotic cells. Only one of these, Pfnek-1, which we ...

2011

APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection

Didier Trono, Francesca Santoni de Sio

BACKGROUND: CD4+ T lymphocytes are the primary targets of HIV1 but cannot be infected when fully quiescent, due to a post-entry block preventing the completion of reverse transcription. Chiu et al. recently proposed that this restriction reflects the actio ...

2009

Controlled Exchange of Chromosomal Arms Reveals Principles Driving Telomere Interactions in Yeast

Michaël Unser, Daniel Sage

The 32 telomeres in the budding yeast genome cluster in three to seven perinuclear foci. Although individual telomeres and telomeric foci are in constant motion, preferential juxtaposition of some telomeres has been scored. To examine the principles that g ...

Cold Spring Harbor Laboratory Press2008

Mid1p/anillin and the septation initiation network orchestrate contractile ring assembly for cytokinesis

Viesturs Simanis

In both animal cells and fungi, cytokinesis proceeds via a contractile actomyosin ring (CAR). Many CAR components and regulators are evolutionarily conserved. In Schizosaccharomyces pombe, the spatial cue for cytokinesis is provided by Mid1p/Anillin, where ...

2008

PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos

Pierre Gönczy, Yemima Suryani Budirahardja

Acquisition of lineage-specific cell cycle duration is an important feature of metazoan development. In Caenorhabditis elegans, differences in cell cycle duration are already apparent in two-cell stage embryos, when the larger anterior blastomere AB divide ...

2008

Formation of aminosilane-oxide interphases

Véronique Michaud, Yves Leterrier, Gabrielle Pax

The aim of this work is to understand the interactions and interphase formation mechanisms between a liquid aminosilane oligomer (γ -APS) and glass, steel or gold surfaces as a function of the pH of the liquid aminosilane. When basic liquid γ -APS (pH 11.4 ...

2006

Tailoring of the practical adhesion between polyethylene and galvanised steel

Véronique Michaud, Gabrielle Pax

The practical adhesion of maleic anhydride grafted polyethylene (MAH-PE) to galvanised steel was studied using 3-point flexure tests, before and after hydrothermal ageing. Before bonding, the electro-galvanised steel was treated with γ -aminopropyltriethox ...

2006

Aminosilanes and hyperbranched polymers for adhesion tailoring between metallic oxides and polyethylene

Gabrielle Pax

Bonding between polyolefins and steel is widely found in applications as diverse as steel wire/cord reinforced polymers, and automotive components where steel and thermoplastics are commonly used. As polyolefins are highly unreactive, because of their low ...

EPFL2005