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Publications associées (32)

Mutations in the polyglutamylase geneTTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility

Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominat ...

Oxford University Press2016

Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes

Pierre Gönczy

Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live ...

Rockefeller University Press2016

Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number

Kai Johnsson, Pierre Gönczy, Michele Graciotti, Zhou Fang

Centrioles are microtubule-based organelles found in most eukaryotic cells and that are critical for the formation of cilia and flagella, as well as of centrosomes in animal cells. The number of centrioles must be strictly regulated in proliferating cells ...

Wiley-Blackwell2016

Detection of environmental glucocorticoids and investigation of their effects using the zebrafish embryo as a model

Anita Orsolya Hidasi

Synthetic glucocorticoids (GCs) are widely used anti-inflammatory drugs. They mimic cortisol, the natural stress hormone in humans and in fish. Cortisol binds and activates the glucocorticoid receptor (GR), which regulates genes governing development, immu ...

EPFL2016

Centrosomes and cancer: revisiting a long-standing relationship

Pierre Gönczy

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting genome instability. The mechanisms governing centrosome assembly and function are increasingly well understood, allowing for a timely reappraisal of this postulate. Thi ...

Nature Publishing Group2015

The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

Pierre Gönczy, Georgios Hatzopoulos, Nicola Jane Dynes, Sheng Kai Pong

Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evol ...

2015

Mechanisms of differential centriole inheritance in C. elegans

Lukas von Tobel

Centrosomes are the principal microtubule organizing center (MTOC) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated to ensure bipolar spindle formation and thus fait ...

EPFL2014

SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans

Pierre Gönczy, Graham Knott, Simon Blanchoud, Lukas von Tobel, Tamara Mikeladze-Dvali

Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sp ...

Public Library of Science2014

Effects of ploidy and sex-locus genotype on gene expression patterns in the fire ant Solenopsis invicta

Chitsanu Khurewathanakul, Oksana Riba Grognuz, Laurent Keller

Males in many animal species differ greatly from females in morphology, physiology and behaviour. Ants, bees and wasps have a haplodiploid mechanism of sex determination whereby unfertilized eggs become males while fertilized eggs become females. However, ...

Royal Soc2014

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Pierre Gönczy, Fernando Romero Balestra

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key ...

Cell Press2014

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Kristina Schoonjans

Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR ...

Wiley-Blackwell2014

Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry

Pierre Gönczy, Davide Demurtas, Paul Guichard, Isabelle Fluckiger, Aitana Neves da Silva, Norbert Majubu

Centrioles are cylindrical microtubule-based structures whose assembly is critical for the formation of cilia, flagella, and centrosomes. The centriole proximal region harbors a cartwheel that dictates the 9-fold symmetry of centrioles. Although the cartwh ...

2013

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