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Publications associées (28)

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Grégoire Courtine, Bernard Schneider, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Lucia Florinda Friedli Wittler, Laetitia Danielle Philippine Baud, Polina Shkorbatova, Janine Beauparlant, Galyna Pidpruzhnykova, Selin Anil, Julie Kreider, Cristina Martinez Gonzalez, Elodie Rey

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Bright Light Delights: Effects of Daily Light Exposure on Emotions, Rest-activity Cycles, Sleep and Melatonin Secretion in Severely Demented Patients

Jean-Louis Scartezzini

Objective: We tested whether the effects of a dynamic lighting system are superior to conventional lighting on emotions, agitation behaviour, quality of life, melatonin secretion and circadian restactivity cycles in severely demented patients. As a compari ...

Bentham Science Publ Ltd2017

WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models

Brian Donal McCabe

SMN (Survival Motor Neuron) deficiency is the predominant cause of spinal muscular atrophy (SMA), a severe neurodegenerative disorder that can lead to progressive paralysis and death. Although SMN is required in every cell for proper RNA metabolism, the re ...

Academic Press Inc Elsevier Science2017

Sleep-dependent consolidation of face recognition and its relationship to REM sleep duration, REM density and Stage 2 sleep spindles

Christian O'Reilly

Face recognition is a highly specialized capability that has implicit and explicit memory components. Studies show that learning tasks with facial components are dependent on rapid eye movement and non-rapid eye movement sleep features, including rapid eye ...

Wiley2017

Regulation Of Neuron-Astrocyte Metabolic Coupling Across The Sleep-Wake Cycle

Pierre Magistretti, Jean-Marie Petit

Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under th ...

Elsevier2016

Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

Pierre Magistretti, Jean-Marie Petit, Maxime Olivier Baud

Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentatio ...

Wiley-Blackwell2016

Glycogen metabolism and the homeostatic regulation of sleep

Pierre Magistretti, Igor Allaman, Jean-Marie Petit, Sophie Burlet Godinot

In 1995 Benington and Heller formulated an energy hypothesis of sleep centered on a key role of glycogen. It was postulated that a major function of sleep is to replenish glycogen stores in the brain that have been depleted during wakefulness which is asso ...

Springer Verlag2015

Wireless Neurosensor for Full-Spectrum Electrophysiology Recordings during Free Behavior

Grégoire Courtine, Hao Li, David Allenson Borton, Yao Lu, Jean François Pierre Laurens

Brain recordings in large animal models and humans typically rely on a tethered connection, which has restricted the spectrum of accessible experimental and clinical applications. To overcome this limitation, we have engineered a compact, lightweight, high ...

Cell Press2014

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