Publications associées à Cypionate d'estradiol

Estrogen receptor signaling in the human breast epithelium

Breast cancer is the most diagnosed malignancy in women worldwide, making effective prevention strategies crucial. Hormonal contraceptives, consisting of a synthetic progesterone receptor agonist alone or in combination with an estrogen, are used by millio ...

EPFL2022

Two-step immobilization of metronidazole prodrug on TEMPO cellulose nanofibrils through thiol-yne click chemistry for in situ controlled release

David Lyndon Emsley, Jasmine Viger-Gravel, Michel Bardet, Julien Bras

Nowadays, drug encapsulation and drug release from cellulose nanofibrils systems are intense research topics, and commercial grades of cellulose nanomaterials are currently available. In this work we present an ester-containing prodrug of metronidazole tha ...

ELSEVIER SCI LTD2021

Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium

Cathrin Brisken, Stéphanie Cagnet

17 beta-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ER alpha. ER alpha acts as a transcription factor but also elicits rapid signaling through a fraction of ER alpha ...

2020

Hormone receptor signaling in estrogen receptor positive breast cancer

Valentina Scabia

Estrogen receptor (ER) and progesterone receptor (PR) signaling tightly interact in controlling postnatal breast development and impinge on breast carcinogenesis. PR is a direct transcriptional target of ER signaling and ER and PR bind closely to DNA and i ...

EPFL2019

Development of a modified QuEChERS method for multi-class pesticide analysis in human hair by GC-MS and UPLC-MS/MS

Luiz Felippe De Alencastro, Edouard René Gilbert Lehmann, Christelle Oltramare

The present study assessed the suitability of using QuEChERS procedure for the simultaneous deter- mination and quantification of 37 multi-class pesticides in human hair. Matrix co-eluted material had a large influence on instrumental response sensitivity. ...

Elsevier2018

Transparent and Robust Silica Coatings with Dual Range Porosity for Enzyme-Based Optical Biosensing

Heinrich Hofmann, Bernard Wenger, Oswaldo Javier Pérez Anguiano, Raphaël Pugin, Emmanuel Scolan

Hierarchically porous transparent silica coatings combine large specific surface area with enhanced pore accessibility for optical biosensing. This paper describes a versatile approach to fabricate optically transparent silica coatings with multiscale poro ...

Wiley-Blackwell2017

Proteome-Wide Effect of 17-beta-Estradiol and Lipoxin A(4) in an Endometriotic Epithelial Cell Line

Endometriosis affects approximately 10% of women of reproductive age. This chronic, gynecological inflammatory disease results in a decreased quality of life for patients, with the main symptoms including chronic pelvic pain and infertility. The steroid ho ...

Frontiers Media Sa2016

Prototropic Exchange Governs T-1 and T-2 Relaxivities of a Potential MRI Contrast Agent Nanozeolite Gd-LTL with a High pH Responsiveness

Lothar Helm

Aqueous suspensions of lanthanide exchsanged zeolite LTL have been investigated by 1H, 17O NMR, and EPR relaxivity studies. Both the longitudinal and the transverse relaxivity of these Gd3+ loaded materials are strongly pH dependent and therefore, they hav ...

American Chemical Society2015

Effects of clofibric acid alone and in combination with 17 beta-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout

Kristin Schirmer

Clofibric acid (CA) is the active substance of lipid lowering drugs. It is resistant to degradation, polar in nature, and has been found ubiquitously in the aquatic environment. Though CA is classified as a peroxisomal proliferator in rodents and is consid ...

Pergamon-Elsevier Science Ltd2014

Probing titanate nanowire surface acidity through methylene blue adsorption in colloidal suspension and on thin films

László Forró, Arnaud Magrez, Endre Horvath

The interaction of the cationic dye methylene blue (MB) with titanate nanowires (TiONWs) was investigated in different pH environments using visible spectroscopy and electrophoresis on thin films as well as in aqueous suspension. The surface charge of the ...

Academic Press Inc Elsevier Science2014

Impact of environmental estrogens on fish considering the diversity of estrogen signaling

Research on endocrine disruption in fish has been dominated by studies on estrogen-active compounds which act as mimics of the natural estrogen, 17 beta-estradiol (E2), and generally exert their biological actions by binding to and activation of estrogen r ...

Elsevier2013

Photocatalytic and phototoxic properties of TiO2-based nanofilaments: ESR and AFM assays

László Forró, Arnaud Magrez, Andrzej Kulik, Andrzej Sienkiewicz, Katarzyna Pierzchala

There is uncertainty in understanding of the relationship between physico-chemical parameters of nanosized titanium dioxide (nano-TiO2) and its toxicity when brought into contact with living cells. This study provides a multidisciplinary experimental insig ...

Informa Healthcare2012

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam, Hui Yang, Bo Song

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

Cathode-supported micro-tubular SOFCs based on Nd1.95NiO4 + δ: Fabrication and characterisation of dip-coated electrolyte layers

Jan Van Herle, Heinrich Hofmann, Paul Bowen, Josef Andreas Schuler, Ulrich Aschauer, Henning Lübbe

Fabrication conditions to obtain dense electrolyte double layers on a porous micro-tubular cathode substrate were investigated. Porous tubes of a nickelate material, Nd1.95NiO4 + δ, were fabricated by cold-isostatic pressing (CIP) and sintering. Thin ﬁlms ...

2009

Molecular and mechanical regulators of lymphatic biology

Joseph Rutkowski

Lymphatic vessels exist in nearly all tissues, yet, despite their omnipresence, there remains a large knowledge gap between the described fundamental roles of lymphatic capillaries and our understanding of their functional biology, adaptive ability, and pa ...

EPFL2008

Conversion of cyclosporine A prodrugs in human tears vs rabbits tears

Arnaud Hamel

The aim of this study was to evaluate the rate and mechanism of conversion of two water-soluble prodrugs of cyclosporine A (CsA) intended for topical delivery to the eye. The new molecules were designed according to the double prodrug concept: a solubilizi ...

2005

Multiple scattering in optical coherence tomography. II. Experimental and theoretical investigation of cross talk in wide-field optical coherence tomography

Theo Lasser, Boris Clément Karamata, Marcel Leutenegger, Stéphane Bourquin, Markus Laubscher

We present a comprehensive study of multiple-scattering effects in wide-field optical coherence tomography (OCT) realized with spatially coherent illumination. Imaging a sample made of a cleaved mirror embedded in an aqueous suspension of microspheres reve ...

2005

Sulfur dioxide mediated syntheses of polyene containing natural products

Laure Bouchez

The goal of this thesis was to open a new route to the synthesis of conjugated trienes using a new SO2-based C-C bond forming reactions developed in Lausanne. In addition, the potential of SO2 for applications in synthetic organic chemistry has been exploi ...

EPFL2004