Publications associées à Radiothérapie externe

Characterization of a flexible a-Si:H detector for in vivo dosimetry in therapeutic x-ray beams

Sylvain Dunand, Nicolas Würsch, Luca Massimiliano Antognini, Jonathan Emanuel Thomet, Matthew James Large

BackgroundThe increasing use of complex and high dose-rate treatments in radiation therapy necessitates advanced detectors to provide accurate dosimetry. Rather than relying on pre-treatment quality assurance (QA) measurements alone, many countries are now ...

Wiley2024

Quantum engineering and detection of advanced radiation beams

Veronica Leccese

Controlling and shaping radiation beams is fundamental for a better understanding of radiation-matter interaction and advancing experimental techniques for material characterization at high spatial resolution. In particular, the current trend in the miniat ...

EPFL2023

Feasibility Study of GaToroid Gantries for Carbon Ions

Bertrand Dutoit, Luca Bottura, Enrico Felcini, Bertrand Dutoit

The use of carbon ions in particle therapy can enhance the treatment quality, introducing higher biological effectiveness compared to photons and protons. Rotating gantries are nowadays used to deliver particle beams from different directions to obtain pre ...

IEEE Institute of Electrical and Electronics Engineers2022

Design of the 590 MeV proton beamline for the proposed TATTOOS isotope production target at PSI

Mike Seidel, Hong Zhang

IMPACT (Isotope and Muon Production with Advanced Cyclotron and Target Technologies) is a proposed initiative envisaged for the high-intensity proton accelerator facility (HIPA) at the Paul Scherrer Institute (PSI). As part of IMPACT, a radioisotope target ...

IOP Publishing2022

Analysis of a Novel Toroidal Configuration for Hadron Therapy Gantries

Enrico Felcini

Hadron therapy refers to a medical treatment that uses hadron beams (i.e. protons and ions) to deliver localized energy that suppresses cancerous cells, sparing the neighbouring healthy tissues from unwanted radiation. The major technical components of a h ...

EPFL2021

Systematic investigations of uranium carbide composites oxidation from micro- to nano-scale: Application to waste disposal

Nhât-Tân Vuong

The production of radioisotope beams at the ISOLDE (Isotope Separator OnLine DEvice) facility at CERN is achieved by irradiating target materials (e.g. uranium carbides and metal foils) with protons. The materials are usually operated at temperatures above ...

EPFL2021

Guided accumulation of active particles by topological design of a second-order skin effect

Ignacio Pagonabarraga Mora, Samuel Sanchez

Collective guidance of out-of-equilibrium systems without using external fields is a challenge of paramount importance in active matter, ranging from bacterial colonies to swarms of self-propelled particles. Designing strategies to guide active matter and ...

Nature Portfolio2021

Gamma Knife radiosurgery as salvage therapy for gangliogliomas after initial microsurgical resection

Constantin Tuleasca

Introduction: Gangliogliomas (GG) are considered WHO grade I rare tumors. While they commonly manifest as temporal lobe epilepsy, they can be located anywhere in the brain. Primary treatment is complete microsurgical resection. Remnant or recurrent GG can ...

2021

SciFi detector and associated method for real-time determination of profile and output factor for small fields in stereotactic radiotherapy

Guido Haefeli, Frédéric Blanc, Plamen Hristov Hopchev, Philippe Pittet

Purpose For determining small-field profile and output factor during stereotactic radiotherapy quality assurance (QA) procedures, we propose a novel system based on the scintillating fiber (SciFi) detector with output image acquisition and processing to al ...

WILEY2020

Magnetic Design of a Superconducting Toroidal Gantry for Hadron Therapy

Luca Bottura, Enrico Felcini, Bertrand Dutoit, Bertrand Dutoit

Hadron and proton therapy are cutting edge techniques for cancer treatment and a great development of specialized medical centers and research facilities is foreseen in the next decades. One of the main obstacles to the penetration of the use of charged pa ...

IEEE Institute of Electrical and Electronics Engineers2020

High-gradient and high-efficiency linear accelerators for hadron therapy

Stefano Benedetti

Hadron beams - approximately 200 MeV protons and 400 MeV/u fully stripped carbon ions - are better suited to treat deep-seated tumours than X ray beams - produced by electrons accelerated by linear accelerators (linacs) to 5-25 MeV - because they leave the ...

EPFL2018

Development of a nano-adjuvant cancer vaccine and its evaluation for melanoma in combination with radiotherapy

Sylvie Hauert

Cancer is the second leading cause of death in the world and melanoma is the deadliest type of skin cancer. Although surgery, radiotherapy and chemotherapy are still standard treatments, the discovery of the role played by the immune system in cancer has a ...

EPFL2018

High gradient linac for proton therapy

Alexej Grudiev, Stefano Benedetti

Proposed for the first time almost 30 years ago, the research on radio frequency linacs for hadron therapy experienced a sparkling interest in the past decade. The different projects found a common ground on a relatively high rf operating frequency of 3 GH ...

2017

Interobserver variability study for daily cone beam computed tomography registration of prostate volumetric modulated arc therapy

Purpose. - This work evaluated the interobserver variability in cone beam computed tomography (CBCT) registration for prostate cancers treated with intensity-modulated radiotherapy. Material and methods. - Twelve technologists realized 286 CBCT/CT registra ...

Elsevier2015

Energy-selective neutron imaging for materials science

Steven Luc X Peetermans

Common neutron imaging techniques study the attenuation of a neutron beam penetrating a sample of interest. The recorded radiograph shows a contrast depending on traversed material and its thickness. Tomography allows separating both and obtaining 3D spati ...

EPFL2015

Enhancing Radiotherapy by Lipid Nanocapsule-Mediated Delivery of Amphiphilic Gold Nanoparticles to Intracellular Membranes

Francesco Stellacci, Randy Patrick Carney, Ye Yang

Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Here we describe a strategy using crosslink-stabilized lipid nanocaps ...

American Chemical Society2014

High Intensity Beam Issues in the CERN Proton Synchrotron

Sandra Aumon

This PhD work is about limitations of high intensity proton beams observed in the CERN Proton Synchrotron (PS) and, in particular, about issues at injection and transition energies. With its 53 years, the CERN PS would have to operate beyond the limit of i ...

EPFL2012

Chiasmatic Infiltration Secondary to Late Malignant Transformation of Retinoma

Alessia Pica

Purpose: To report the lethal course of malignant transformation of retinoma in an adult. Methods: Case report. A 40-year-old patient presented with retinoma in his right eye and retinoblastoma in his left eye. Enucleation was recommended but refused and t ...

Informa Healthcare2012

High intensity profile monitor for time resolved spectrometry at the CLIC Test Facility 3

The power source of the Compact Linear Collider (CLIC) relies on the generation and deceleration of a high-intensity electron drive beam. In order to provide the best radio-frequency (RF) to beam-energy transfer efficiency, the electron beam is accelerated ...

2012

Spatiotemporal motion estimation for respiratory-correlated imaging of the lungs

Jan Kybic

Purpose: Four-dimensional computed tomography (4D CT) can provide patient-specific motion information for radiotherapy planning and delivery. Motion estimation in 4D CT is challenging due to the reduced image quality and the presence of artifacts. We aim t ...

2011