Publications associées à Habenula

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Maria del Carmen Sandi Perez, Elias Georges Gebara, Ana del Rocio Conde Moro

Social behaviors such as cooperation are crucial for mammals. A deeper knowledge of the neuronal mechanisms underlying cooperation can be beneficial for people suffering from pathologies with impaired social behavior. Our aim was to study the brain activit ...

Springer2024

Investigating the Serotonergic Modulation of Orientation Tuning of Neurons in Primary Visual Cortex of Anesthetized Mice

Parviz Ghaderi

Introduction: Sensory processing is profoundly regulated by brain neuromodulatory systems. One of the main neuromodulators is serotonin which influences higher cognitive functions, such as different aspects of perceptual processing. Accordingly, malfunctio ...

Iran Univ Medical Sciences2023

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Maria del Carmen Sandi Perez, Lijing Xin, Ioannis Zalachoras, Olivia Zanoletti, Simone Astori, João Pedro de Matos Rodrigues, Fiona Hollis, Pascal Steiner, Alina Veronika Irene Strasser, Eva Ramos Fernandez

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant level ...

2022

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice

Bernard Schneider

Background Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell ...

2020

Risk prediction error signaling: A two-component response?

Michael Herzog, Ophélie Gladys Favrod, Kerstin Preuschoff, Marc Michael Lauffs, Sophie Alberta Catherine Geoghan

Organisms use rewards to navigate and adapt to (uncertain) environments. Error-based learning about rewards issupported by the dopaminergic system, which is thought to signal reward prediction errors to make adjustmentsto past predictions. More recently, t ...

2020

A VTA to Basal Amygdala Dopamine Projection Contributes to Signal Salient Somatosensory Events during Fear Learning

Ralf Schneggenburger, Olexiy Kochubey, Wei Tang, Michael Kintscher

The amygdala is a brain area critical for the formation of fear memories. However, the nature of the teaching signal(s) that drive plasticity in the amygdala are still under debate. Here, we use optogenetic methods to investigate the contribution of ventra ...

2020

Neural Correlates of Reinforcement Learning: eligibility trace, reward prediction error, novelty and surprise

He Xu

In reinforcement learning (RL), an agent makes sequential decisions to maximise the reward it can obtain from an environment. During learning, the actual and expected outcomes are compared to tell whether a decision was good or bad. The difference between ...

EPFL2020

A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity

Srikanth Ramaswamy, Vignayanandam Ravindernath Muddapu

Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root cause of this cell loss is ...

2019

The dopaminergic VTA - basal amygdala projection contributes to signal aversive state in fear memory

Wei Tang

Dopamine released from midbrain neurons is an important neuromodulatory signal during associative learning in many forebrain circuits. One model of associative learning is auditory cued fear learning, during which an innocuous sensory percept like a tone ( ...

EPFL2018

Time course of prediction errors in sequential decision making

Michael Herzog, He Xu

In reinforcement learning, an agent makes sequential decisions to maximize reward. During learning, the actual and expected outcome are compared to tell whether a decision was good or bad. The difference between the actual outcome and expected outcome is t ...

2018

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis, Jocelin Grosse, Ioannis Zalachoras, Olivia Zanoletti, Marie-Isabelle Guillot de Suduiraut, Michael van der Kooij, Laura Lozano Montes, Sonia Abad Florensa

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

Martin Vogel

Background: In recent years, deep brain stimulation (DBS) has emerged as a promising treatment option for patients suffering from treatment-resistant depression (TRD). Several stimulation targets have successfully been tested in clinical settings, includin ...

Elsevier Science Inc2015

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Rolf Gruetter, Patrick Aebischer, Bernard Schneider, Mélanie Craveiro, Philippe Guillaume Coune, Meret Gaugler

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Wiley-Blackwell2013

NR5A2 Regulates Lhb and Fshb Transcription in Gonadotrope-Like Cells In Vitro, but Is Dispensable for Gonadotropin Synthesis and Fertility In Vivo

Johan Auwerx, Kristina Schoonjans, Yiping Wang, Xin Zhou, Vikas Kumar

Successful mammalian reproduction depends on proper synthesis of the pituitary-derived glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Several transcription factors cooperate to activate cell-specific and hormone-reg ...

Public Library of Science2013

Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

Philippe Guillaume Coune

While Parkinson's disease has been described nearly 200 years ago, the mechanisms leading to the degeneration of selectively vulnerable populations of neurons, such as dopaminergic neurons in the substantia nigra, remain mostly unknown. Our poor understand ...

EPFL2011

MicroPET imaging of 5-HT1A receptors in rat brain: a test-retest [F-18]MPPF study

Purpose Earlier studies have shown that positron emission tomography (PET) imaging with the radioligand [F-18] MPPF allows for measuring the binding potential of serotonin 5-hydroxytryptamine(1A) (5-HT1A) receptors in different regions of animal and human ...

Springer-Verlag2009

Human insula activation reflects risk prediction errors as well as risk

Kerstin Preuschoff

Understanding how organisms deal with probabilistic stimulus-reward associations has been advanced by a convergence between reinforcement learning models and primate physiology, which demonstrated that the brain encodes a reward prediction error signal. Ho ...

2008

Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

Patrick Aebischer, Bernard Schneider

Parkinson disease (PD) is characterized by the progressive degeneration of substantia nigra dopaminergic neurons projecting to the striatum. Since the deficit in striatal dopamine is the main cause of PD symptoms, it appears critical to preserve axon termi ...

2004