Publications associées à Pneumopathie acquise sous ventilation mécanique

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

The abusive use of antimicrobial drugs during the last eighty years has favoured the natural selection of resistant pathogens able to neutralise drugs efficiently. Nowadays, antimicrobial resistance contributes to millions of deaths yearly, threatens the e ...

EPFL2023

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots

Francesco Stellacci, Inyoung Yonah Lee

Infections caused by multidrug-resistant (MDR) bacteria pose an impending threat to humanity, as the evolution of MDR bacteria outpaces the development of effective antibiotics. In this work, we use indium phosphide (InP) quantum dots (QDs) to treat infect ...

ROYAL SOC CHEMISTRY2022

Microfabricated nanomotion detectors for rapid cells viability tests

Anton Malovichko

The widespread use of antibiotics and antifungal drugs has provoked an increasing number of multi-resistant bacteria and fungi. The emergence of multiresistance to antibiotics has been now recognized as a very serious public health issue. In order to targe ...

EPFL2021

Monitoring Tuberculosis Drug Activity in Live Animals by Using Near-Infrared Fluorescence Imaging

Stewart Cole, Raphael Christopher Sommer

Worldwide, tuberculosis (TB) is the leading cause of death due to infection with a single pathogenic agent, Mycobacterium tuberculosis. In the absence of an effective vaccine, new, more powerful antibiotics are required to halt the growing spread of multid ...

AMER SOC MICROBIOLOGY2019

Population Structure, Molecular Epidemiology, and beta-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States

Luciano Andres Abriata

Stenotrophomonas maltophilia is a Gram-negative, nonfermenting, environmental bacillus that is an important cause of nosocomial infections, primarily associated with the respiratory tract in the immunocompromised population. Aiming to understand the popula ...

2019

Development of an AFM-based nanomotion detection device for microbiological samples

Wojciech Chomicki

The main goals of this thesis pertain to the development of a device capable of detecting microorganism viability through monitoring the oscillations of a microscopic cantilever transducer, to improve the presently used device and to attempt to explain in ...

EPFL2019

Metal Distribution and Characterization of Cultivable Lead-Resistant Bacteria in Shooting Range Soils

Aline Sondra Adler

Shooting ranges represent about 10% of polluted sites in Switzerland. This pollution, mainly consisting of lead (Pb) and antimony (Sb), can spread into the local groundwater, wildlife and plants. In this study, shooting range stop butt soils (elevated soil ...

Taylor & Francis Inc2016

OprD Repression upon Metal Treatment Requires the RNA Chaperone Hfq in Pseudomonas aeruginosa

Rodrigo Manuel Gonzalez, Tiziana Scrignari

The metal-specific CzcRS two-component system in Pseudomonas aeruginosa is involved in the repression of the OprD porin, causing in turn carbapenem antibiotic resistance in the presence of high zinc concentration. It has also been shown that CzcR is able t ...

Mdpi Ag2016

More DNA–Aptamers for Small Drugs: A Capture–SELEX Coupled with Surface Plasmon Resonance and High-Throughput Sequencing

Carlotta Guiducci, Fabio Mario Spiga

To address limitations in the production of DNA aptamers against small molecules, we introduce a DNA-based capture-SELEX (systematic evolution of ligands by exponential enrichment) protocol with long and continuous randomized library for more flexibility, ...

ACS Publications2015

Surface Grafted Polymer Brushes : A Versatile Platform for Antibacterial Applications

Sorin Alexandru Ibanescu

Various strategies have been proposed and applied to prepare antibacterial materials able to respond to different requirements specific for antibacterial applications. Among diverse strategies the approach based on substrates modification with polymer brus ...

EPFL2015

Identification of airway bacterial colonization by an electronic nose in Chronic Obstructive Pulmonary Disease

Background: Airway bacterial colonization by potentially pathogenic microorganisms occurs in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases airway inflammation and influences outcomes negatively. Yet, its diagnosis ...

Elsevier2014

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Stewart Cole, Claudia Sala, Ruben Hartkoorn, Andrej Benjak, Ming Zhang, Anthony Vocat, Jan Lars Rybniker, Jeffrey Chen, Edina Rita Székely

Mycobacterium tuberculosis (Mtb) requires protein secretion systems like ESX-1 for intracellular survival and virulence. The major virulence determinant and ESX-1 substrate, EsxA, arrests phagosome maturation and lyses cell membranes, resulting in tissue d ...

Cell Press2014

Functional Analysis of PGRP-LA in Drosophila Immunity

Bruno Lemaitre, Juan Camilo Paredes Escobar, Nichole Broderick

PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet unc ...

Public Library of Science2013