Publications associées à Capsule (pharmacie galénique)

From Surfactants to Viscoelastic Capsules

Esther Amstad, Gaia De Angelis, Natascha Ilena Gray

Micrometer sized capsules are often used as single entities for the encapsulation and release of active ingredients, for example in food, cosmetics, and drug delivery. Important parameters that determine the stability of capsules and the release of reagent ...

WILEY2023

Direct encapsulation of biomolecules in semi-permeable microcapsules produced with double-emulsions

Sebastian Maerkl, Grégoire Michielin

Compartmentalization can serve different purposes such as the protection of biological active substances from the environment, or the creation of a unique combination of biomolecules for diagnostic, therapeutic, or other bioengineering applications. We pre ...

Nature Portfolio2022

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Fabrication of micrometer-sized drops as templates for particles

Mathias Steinacher

Drops are omnipresent in our daily life for example in the form of rain drops or as oil drops in a salad dressing. On a technological basis, drops can be used to conduct chemical or biological reactions. These drops often serve as templates to produce mate ...

EPFL2021

Microfluidics and cell-free synthetic biology in the development of new diagnostic and therapeutic platforms

Grégoire Michielin

In phenylketonuria, absence or malfunction of the phenylalanine hydroxylase enzyme results in toxic accumulation of phenylalanine in the body. An injectable recombinant enzyme therapy was recently approved and has the potential to improve the quality of li ...

EPFL2021

Two-step immobilization of metronidazole prodrug on TEMPO cellulose nanofibrils through thiol-yne click chemistry for in situ controlled release

David Lyndon Emsley, Jasmine Viger-Gravel, Michel Bardet, Julien Bras

Nowadays, drug encapsulation and drug release from cellulose nanofibrils systems are intense research topics, and commercial grades of cellulose nanomaterials are currently available. In this work we present an ester-containing prodrug of metronidazole tha ...

ELSEVIER SCI LTD2021

Bioinspired Viscoelastic Capsules: Delivery Vehicles and Beyond

Esther Amstad, Gianluca Nicolas Etienne, Irvine Lian Hao Ong

Microcapsules are often used as individually dispersed carriers of active ingredients to prolong their shelf life or to protect premature reactions with substances contained in the surrounding. This study goes beyond this application and employs microcapsu ...

Wiley2019

Mechano-responsive microcapsules with uniform thin shells

Esther Amstad, Antoine Claude Jean Vian

Capsules often prolong the shelf-life of active ingredients, such as many types of drugs, food additives, or cosmetic substances, because they delay oxidation of these substances or prevent their reactions with molecules contained in the surrounding. If ca ...

2019

Capsules with submicron shells: production, stability, and leakage behavior

Antoine Claude Jean Vian

Capsules are often employed to prolong the shelf-life of active ingredients such as many drugs, food additives, or cosmetic substances because they delay their oxidation or prevent interactions with molecules contained in the surrounding. If designed prope ...

EPFL2018

Microfluidic Production of Capsules-in-Capsules for Programed Release of Multiple Ingredients

Esther Amstad

Capsules with thin shells have a high‐loading capacity and are thus well‐suited containers for reagents that must be stored in confined volumes. Capsules contained in larger capsules, so‐called double capsules, allow the encapsulation of distinct reagents ...

Wiley2018

Microfluidics: A Tool to Control the Size and Composition of Particles

Esther Amstad

Particles and capsules are used as containers for active ingredients to delay their degradation and control the location and kinetics of their release. Key to a successful application of these containers is a good control over their size, composition, and ...

Swiss Chemical Soc2017

Assessment of solvent capsule-based healing for woven fibre-reinforced epoxies

Erica Manfredi

Structural fibre-reinforced composites based on brittle matrices such as epoxy resins may be subject to short-term subcritical matrix damage that develops with time to the point where it may compromise the integrity of the structure. Currently, components ...

EPFL2015

Proliferation, Morphology, and Pluripotency of Mouse Induced Pluripotent Stem Cells in Three Different Types of Alginate Beads for Mass Production

Yoji Tabata

Induced pluripotent stem cells (iPSCs) are expected to be an ideal cell source for biomedical applications, but such applications usually require a large number of cells. Suspension culture of iPSC aggregates can offer high cell yields but sometimes result ...

Wiley-Blackwell2014

Fluid-mediated parallel self-assembly of polymeric micro-capsules for liquid encapsulation and release

Jürgen Brugger, Alcherio Martinoli, Luis Guillermo Villanueva Torrijo, Massimo Mastrangeli, Cristina Martin Olmos, Victor Javier Cadarso Busto, Loïc Jacot-Descombes, Grégory Mermoud, Rosario Maurizio Gullo

Fluid-mediated self-assembly is one of the most promising routes for assembling and packaging smart microsystems in a scalable and cost-efficient way. In this work the pairwise fluidic self-assembly of 100 μm-sized SU-8 cylinders is studied with respect to ...

2013

Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

Osiris Marroquin Belaunzaran

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population. AD currently affects approximately 27 million people worldwide. A pathological hallmark of AD is the accumulation and deposition of the amyloid beta (Aβ) pe ...

EPFL2009