Publications associées à Liquide biologique

Ultra-High Sensitivity Silicon Nanowire Array Biosensor Based on a Constant-Current Method for Continuous Real-Time pH and Protein Monitoring in Interstitial Fluid

Mihai Adrian Ionescu, Ali Saeidi, Yann Christophe Sprunger, Luca Capua

In this paper we demonstrate ultra-high sensitivity silicon nanowires pH and protein sensing on the same Silicon nanowire array platform by using a constant current method and monitoring the drain voltage as function of analyte concentration. The injected ...

IEEE2023

Monitoring of Protein and pH Levels in Human Biofluids using FD-SOI Silicon Nanowire Arrays

Luca Capua

Medical research and technological advancements are heading towards tailored healthcare approaches that prioritize individual needs, allowing for more accurate diagnoses, more effective treatments, and better patient outcomes overall. One such approach is ...

EPFL2023

Review on Uric Acid Recognition by MOFs with a Future in Machine Learning

Shaswati Mandal

Uric acid (UA) is produced from purine metabolism and serves as a prevalent biomarker for multiple diseases including cancer. Hyperuricemia or hypouricemia can cause multiple dysfunctions throughout the biological processes. Consequently, there is a pressi ...

Amer Chemical Soc2023

Label-Free C-Reactive Protein Si Nanowire FET Sensor Arrays With Super-Nernstian Back-Gate Operation

Mihai Adrian Ionescu, Yann Christophe Sprunger, Luca Capua, Felix Risch, Ron Gill, Aristea Grammoustianou

We present a CMOS-compatible double gate and label-free C-reactive protein (CRP) sensor, based on silicon on insulator (SOI) silicon nanowires arrays. We exploit a reference subtracted detection method and a super-Nernstian internal amplification given by ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Alpha-synuclein as a Potential Biomarker for Parkinson’s Disease and Other Synucleinopathies: Gaps, Challenges, and Opportunities

Hilal Lashuel, Pedro José Santana Ribeiro Magalhães

Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with ...

2022

Piezoelectric suspended microchannel resonators

Damien Maillard

The objective of this PhD thesis is the development of a microfluidic platform for the real-time measurements of the mechanical properties of biological analytes at the single entity level. The systems developed for these purposes consist of piezoelectrica ...

EPFL2022

Conjugate heat transfer in isolated granular clusters with interstitial fluid using lattice Boltzmann method

Mehrdad Kiani Oshtorjani

The conjugate heat transfer in mixtures of a fluid and single granular clusters is studied in this paper using a novel lattice Boltzmann method (LBM) programmed for parallel computation on the graphics processing unit (GPU). The LBM is validated for heat c ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Turbulent transport regimes in the tokamak boundary and operational limits

Paolo Ricci, Maurizio Giacomin

Two-fluid, three-dimensional, flux-driven, global, electromagnetic turbulence simulations carried out by using the GBS (Global Braginskii Solver) code are used to identify the main parameters controlling turbulent transport in the tokamak boundary and to d ...

2022

Opportunities and challenges of alpha-synuclein as a potential biomarker for Parkinson's disease and other synucleinopathies

Hilal Lashuel, Pedro José Santana Ribeiro Magalhães

Parkinson's disease (PD), the second most common progressive neurodegenerative disease, develops and progresses for 10-15 years before the clinical diagnostic symptoms of the disease are manifested. Furthermore, several aspects of PD pathology overlap with ...

NATURE PORTFOLIO2022

Comparative Analysis of Total Alpha-Synuclein (alpha SYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified alpha SYN Proteoforms

Hilal Lashuel, Lorène Aeschbach, Mohamed Bilal Fares, Lara Petricca, Ritwik Burai, Layane Hanna-el-Daher

Background: The development of therapeutics for Parkinson's disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression, and assessing target engagement. Attempts to develop diagnostic assays b ...

IOS PRESS2022

Adsorption of progesterone onto microplastics and its desorption in simulated gastric and intestinal fluids

Florian Frédéric Vincent Breider, Dominique Grandjean, Thibault Béranger Masset, Cécilia Laetitia Carla Siri, Yang Liu

The sorption of Hydrophobic Organic Compound (HOC) onto microplastics is relatively well reported in the literature, while their desorption remains poorly investigated, and especially in biological ﬂuids. The present study investigated the sorption and des ...

2021

Nanoparticle-enhanced Imaging Based Plasmonic Biosensor

Alexander Belushkin

Efficient medical care fundamentally relies on the ability to provide a timely and accurate diagnosis. Thanks to advances in biomedical research, specific molecules called diagnostic molecular biomarkers have been discovered in the human body that help ind ...

EPFL2020

Geometric mixing

Nicolas Piro Mastracchio

Mixing fluids often involves a periodic action, like stirring one's tea. But reciprocating motions in fluids at low Reynolds number, in Stokes flows where inertia is negligible, lead to periodic cycles of mixing and unmixing, because the physics, molecular ...

ROYAL SOC2020

An Overview of Serum Albumin Interactions with Biomedical Alloys

Stefano Mischler, Anna Neus Igual Muñoz, Oksana Klok

Understanding the interactions between biomedical alloys and body fluids is of importance for the successful and safe performance of implanted devices. Albumin, as the first protein that comes in contact with an implant surface, can determine the biocompat ...

2020

Dynamic response of a compressible binary fluid mixture

Ignacio Pagonabarraga Mora

Binary fluids are present in a wide variety of systems at microscales, such as microfluidic devices containing drops, fluids with air bubbles trapped in them, and devices designed to mix fluids or to make two fluid substances react. Microfluidics devices a ...

2020

Experimental studies of hydro-mechanical couplings in Enhanced Geothermal Reservoirs

Mateo Alejandro Acosta

Enhanced Geothermal Systems (EGS) allow for worldwide geothermal electricity production. They target deep (3-5 km), fractured rock reservoirs whose permeability is artificially increased through hydraulic stimulations (fluid injections). The injections mod ...

EPFL2020

Experimental Drainage Device to Reduce Lymphoedema in a Rat Model

Nikolaos Stergiopoulos, Marco Pisano, Melody Swartz, Valentina Triacca

Objective: Despite recent advances in pharmacological research and microsurgery, lymphoedema remains an incurable disease that deeply affects quality of life. There is an urgent need for innovative approaches to restore continuous lymph flow in affected ti ...

2019

2G/3G Serpentine Shape Inverted-F Antenna for Near Body Application

Anja Skrivervik, Nuno Miguel Faria Pires

In this contribution, we present a miniature antenna placed in a leg bracelet for body worn applications. It operates in both the 820-960 MHz and the 1.7-2.1 GHz bands. The radiating element, based on an inverted-F antenna, occupies a 37 mm × 37 mm area an ...

IEEE2019

Microstructured Multimaterial Fibers for Microfluidic Sensing

Fabien Sorin, Wei Yan, Alexis Gérald Page, Dang Tùng Nguyen, Chaoqun Dong

The thermal drawing of a uniform capillary-like fiber that integrates an encapsulated microchannel and an embedded capacitor system within a polymeric cladding is demonstrated. Such a fiber construct has versatile functionalities applicable to microfluidic ...

Wiley2019

PZE-transduced Suspended Microchannel Resonators for sensing applications

Annalisa De Pastina

This PhD thesis aims at developing a system which can measure the mechanical properties of fluidic samples in the picoliter range. The ultimate goal is the characterization of cancer cells and viscoelastic fluids (i.e. biological fluids), in order to study ...

EPFL2018