Publications associées à Pseudomonas

Bacterial colonization in realistic environments: how mechanics impact biofilm formation in the wild and during infection

A variety of physical inputs acts onto bacteria in nature. However, these are most often ignored in the studies of their physiology. There is now increasing evidence indicating that bacteria respond to physical stimuli, including mechanical forces. Yet, qu ...

EPFL2023

Material Substrate Physical Properties Control Pseudomonas aeruginosa Biofilm Architecture

Alexandre Louis André Persat, Alice Cont

The biofilm lifestyle is the most widespread survival strategy in the bacterial world. Pseudomonas aeruginosa biofilms cause chronic infections and are highly recalcitrant to antimicrobials. The genetic requirements allowing P. aeruginosa to grow into biof ...

AMER SOC MICROBIOLOGY2023

A Rapidly Responsive Sensor for Wireless Detection of Early and Mature Microbial Biofilms

Hubert Girault, Andreas Stephan Lesch, Bhawna Nagar, Wanderson Oliveira Da Silva

Biofilm-associated infections, which are able to resist antibiotics, pose a significant challenge in clinical treatments. Such infections have been linked to various medical conditions, including chronic wounds and implant-associated infections, making the ...

Wiley-VCH Verlag GmbH2023

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

Lorenzo Anton-Louis Talà

Bacteria are ubiquitously found in all sorts of environment. They're found in the ocean, soil, or even in our guts or on our skin. Independently of their niche, they can transition from a planktonic state were they freely swim in an aqueous environment to ...

EPFL2022

In vitro synergistic action of TAT-RasGAP 317-326 peptide with antibiotics against Gram-negative pathogens

Grazia Vizzarro

Objectives: Multidrug-resistant (MDR) bacteria are a continuously increasing threat for medicine, caus-ing infections recalcitrant to antibiotics. Antimicrobial peptides (AMPs) were identified as alternatives to antibiotics, being naturally occurring short ...

2022

Genomic and metabolic adaptations of biofilms to ecological windows of opportunity in glacier-fed streams

Tom Ian Battin, Hannes Markus Peter, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Leïla Ezzat, Massimo Bourquin, Matteo Tolosano, Tyler Joe Kohler, Stylianos Fodelianakis, Paraskevi Pramateftaki, Vincent Henri De Staercke, Michail Styllas, Martina Andrea Schön

In glacier-fed streams, ecological windows of opportunity allow complex microbial biofilms to develop and transiently form the basis of the food web, thereby controlling key ecosystem processes. Using metagenome-assembled genomes, we unravel strategies tha ...

Springer2022

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots

Francesco Stellacci, Inyoung Yonah Lee

Infections caused by multidrug-resistant (MDR) bacteria pose an impending threat to humanity, as the evolution of MDR bacteria outpaces the development of effective antibiotics. In this work, we use indium phosphide (InP) quantum dots (QDs) to treat infect ...

ROYAL SOC CHEMISTRY2022

Phototransformation kinetics of cyanobacterial toxins and secondary metabolites in surface waters

Sandro Marcotullio

Background Cyanobacteria and their toxins occur in high concentrations during the so-called bloom events in surface waters. To be able to assess the risks associated with cyanobacterial blooms, we need to understand the persistence and fate processes of th ...

2021

Pilus production in Acinetobacter baumannii is growth phase dependent and essential for natural transformation

Melanie Blokesch, Nina Vesel

Acinetobacter baumannii is a severe threat to human health as a frequently multidrug-resistant hospital-acquired pathogen. Part of the danger from this bacterium comes from its genome plasticity and ability to evolve quickly by taking up and recombining ex ...

American Society for Microbiology2021

Functional and structural characterization of Serratia marcescens ExbB: determinants of the interaction with HasB/TonB

Henning Paul-Julius Stahlberg

ExbBD is part of a cytoplasmic membrane molecular motor driven by the proton-motive force. It belongs to the larger family of motors involved in nutriment import across the outer membrane of Gram-negative bacteria (ExbBD), flagellar rotation (MotAB) or lat ...

2021

Adaptation of Pseudomonas aeruginosa to constant sub-inhibitory concentrations of quaternary ammonium compounds

Urs von Gunten, Giovanni Dietler, Sandor Kasas, Florian Frédéric Vincent Breider, Leonardo Venturelli, Myriam Borgatta, Margaux Océane Voumard

Quaternary ammonium compounds (QACs) are widely used in consumer products for disinfection purposes. QACs are frequently detected in aquatic systems at sub-inhibitory concentrations and were found to affect the development of antimicrobial resistance if ba ...

2020

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko, Alice Marra, Jasquelin Peña

Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...

National Academy of Sciences2020

Biofilms deform soft surfaces and disrupt epithelia

Alexandre Louis André Persat, Alice Cont, Tamara Rossy

During chronic infections and in microbiota, bacteria predominantly colonize their hosts as multicellular structures called biofilms. A common assumption is that biofilms exclusively interact with their hosts biochemically. However, the contributions of me ...

2020

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

Bart Deplancke, Vincent Roland Julien Gardeux, Maroun Bou Sleiman, Virginie Sandra Braman, Riccardo Dainese, Maria Litovchenko, Michael Vincent Frochaux, Dani Osman, Brian Dennis Hollis, Tommaso Andreani

Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...

2020

Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies

Vassily Hatzimanikatis, Ljubisa Miskovic, Milenko Tokic

Background: Pseudomonas putida is a promising candidate for the industrial production of biofuels and biochemicals because of its high tolerance to toxic compounds and its ability to grow on a wide variety of substrates. Engineering this organism for impro ...

2020

Inkjet Printed Carbon Nanotube Electrodes for Measuring Pyocyaninand Uric Acid in a Wound Fluid Simulant and Culture Media

Hubert Girault, Andreas Stephan Lesch, Milica Jovic

Polyacrylamide-coated, carbon nanotube (PA/CNT)electrodes were prepared by an ink-jet printing process and used to measure pyocyanin and uric acid in a wound fluid simulant at 37 oC.These two moleculesare potential indicators of infection and therefore the ...

2019

Metal nanoparticles functionalized carbon nanotubes for efficient catalytic application

Lakshmi Devi Chakkarapani

Surfactant molecules were non-covalently functionalized with carbon nanotubes (CNTs) to retain the remarkable properties of CNTs. Moreover, silver nanoparticles (AgNPs) were immobilized onto CNTs-surfactant matrixes to enhance the catalytic and biomedical ...

2019

Microbiological contamination of cosmetic products - observations from Europe, 2005-2018

Florentino Luciano Caetano Dos Santos

Background Although cosmetic products are not expected to be fully aseptic, their potential microbiological contamination might be dangerous, especially for immunocompromised patients. The extent of such contamination of cosmetics in Europe is poorly studi ...

2019

Occurrence and ecological determinants of the contamination of floodplain wetlands with Klebsiella pneumoniae and pathogenic or antibiotic-resistant Escherichia coli

François Gillet, Charles Pierre Roger Henriot

The survival and multiplication of human pathogenic and antibiotic-resistant bacteria in ecosystems is of increasing concern but has been little explored. Wetlands can be contaminated by water fluxes from rivers and may present environmental conditions lea ...

Oxford University Press (OUP)2019

Population Structure, Molecular Epidemiology, and beta-Lactamase Diversity among Stenotrophomonas maltophilia Isolates in the United States

Luciano Andres Abriata

Stenotrophomonas maltophilia is a Gram-negative, nonfermenting, environmental bacillus that is an important cause of nosocomial infections, primarily associated with the respiratory tract in the immunocompromised population. Aiming to understand the popula ...

2019