Potentialisation à long terme

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Publications associées (29)

Mitochondrial respiratory chain dysfunction disrupts intracellular cholesterol homeostasis

Christopher Tadhg James Wall

Mitochondrial diseases are rare and severe conditions with debilitating symptoms. Biochemical defects in mitochondria however are common. The difference between these two frequencies is suspected to lie in the capability of the cells to adapt to the homeos ...

EPFL2022

High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons

James Gonzalo King, Suraj Honnuraiah

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, we have only just started to describe their properties in the human brain. Here, we investigate the capacity of human ...

2022

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Adrien Michel Achille Devresse, Hugo Thabo Dictus, Matthias Wolf, Felix Schürmann, Daniel Keller, Werner Alfons Hilda Van Geit, Pramod Shivaji Kumbhar, Alexis Arnaudon, Jean-Denis Georges Emile Courcol, András Ecker, Juan Bautista Hernando Vieites, Michael Emiel Gevaert, Huanxiang Lu, Liesbeth Maria L Vanherpe, Cyrille Pierre Henri Favreau, Vishal Sood, Sirio Bolaños Puchet, Ran Levi, James Bryden Isbister, Judit Planas Carbonell, Daniela Egas Santander, Joni Henrikki Herttuainen, Samuel Lieven D. Lapere, Christoph Pokorny, Thomas Brice Delemontex, Nicolas René Jean Ninin, Juan Luis Riquelme Roman, Alexander Dietz, Benoît Jean-Albert Coste, Gianluca Ficarelli,

Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning

Maria del Carmen Sandi Perez

It is widely accepted that some types of learning involve structural and functional changes of hippocampal synapses. Cell adhesion molecules neural cell adhesion molecule (NCAM), its polysialylated form polysialic acid to NCAM (PSA-NCAM), and L1 are promin ...

FRONTIERS MEDIA SA2022

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

Johan Auwerx, Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Marie-Isabelle Guillot de Suduiraut, João Pedro de Matos Rodrigues, Wei Huang, Ioannis Zalachoras, Sriparna Ghosal, Laia Morato Fornaguera, Lei Cao

Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes in visceral fat deposition and in social behaviors. However, whether stress-induced changes in adipose tissue can affect fat-to-b ...

2022

Microstructural developments of limestone calcined clay cement (LC3) pastes after long-term (3 years) hydration

Karen Scrivener, Franco Alberto Zunino Sommariva

LC3 is one of the most promising alternatives for a high-performance blended cement with a significantly lower clinker content and with potential for worldwide adoption. For this reason, understanding its long-term performance is relevant to ensure service ...

Pergamon-Elsevier Science Ltd2022

Structure-preserving approaches and data-driven closure modeling for model order reduction

Nicolò Ripamonti

In this thesis, we propose model order reduction techniques for high-dimensional PDEs that preserve structures of the original problems and develop a closure modeling framework leveraging the Mori-Zwanzig formalism and recurrent neural networks. Since high ...

EPFL2022

Population-scale dietary interests during the COVID-19 pandemic

Robert West, Kristina Gligoric

The SARS-CoV-2 virus has altered people's lives around the world. Here we document population-wide shifts in dietary interests in 18 countries in 2020, as revealed through time series of Google search volumes. We find that during the first wave of the COVI ...

Nature Portfolio2022

Cortical sensory processing across motivational states during goal-directed behavior

Carl Petersen, Matthieu Pierre Auffret, Georgios Foustoukos, Sami El-Boustani, Johannes Maria Mayrhofer, Maëlle Guyoton

Behavioral states can influence performance of goal-directed sensorimotor tasks. Yet, it is unclear how altered neuronal sensory representations in these states relate to task performance and learning. We trained water-restricted mice in a two-whisker disc ...

2022

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Janis Lazovskis

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024