Publications associées à Syndrome d'Asperger

Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Farnaz Delavari, Nada Kojovic

The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns ( ...

Wiley2024

An immersive virtual reality system for ecological assessment of peripersonal and extrapersonal unilateral spatial neglect

Olaf Blanke, Andrea Serino, Roberta Ronchi, Ravi Tej Sai Giridhar Tadi

BackgroundUnilateral spatial neglect (USN) is a debilitating neuropsychological syndrome that often follows brain injury, in particular a stroke affecting the right hemisphere. In current clinical practice, the assessment of neglect is based on old-fashion ...

BioMed Central2023

Empathetic Conversational Agents for Distress Support

Kalpani Anuradha Welivita

Due to the increasing demands of today's fast-paced world, mental health concerns are on the rise, which necessitates innovative approaches to provide support to those in need. Open-domain conversational agents known as chatbots, offer a unique opportunit ...

EPFL2023

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen, Thamyris Silva

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

2023

Sex Differences in Comorbidity Combinations in the Swedish Population

Patrick Karl Alois Neff

High comorbidity rates, especially mental-physical comorbidity, constitute an increasing health care burden, with women and men being differentially affected. To gain an overview of comorbidity rates stratified by sex across a range of different conditions ...

MDPI2022

The diagnostic potential of multimodal neuroimaging measures in Parkinson's disease and atypical parkinsonism

Chang-Hyun Park

Introduction For the diagnosis of Parkinson's disease (PD) and atypical parkinsonism (AP) using neuroimaging, structural measures have been largely employed since structural abnormalities are most noticeable in the diseases. Functional abnormalities have b ...

2020

Visual masking deficits in schizophrenia: A view into the genetics of the disease through an endophenotype

Michael Herzog, Jacques Fellay, Maya Roinishvili, Flavia Aurelia Shoko Hodel

Schizophrenia is a chronic disorder determined by a complex mix of genetic and environmental factors. To better understand the contributions of human genetic variation to schizophrenia, we performed a genome-wide association study of a validated endophenot ...

2018

Diffusion-weighted imaging evidence of altered white matter development from late childhood to early adulthood in Autism Spectrum Disorder

Djalel Eddine Meskaldji, Fikret Isik Karahanoglu

Autism Spectrum Disorder (ASD) is thought to reflect disrupted development of brain connectivity characterized by white matter abnormalities and dyscoordination of activity across brain regions that give rise to core features. But there is little consensus ...

2018

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Graham Knott, Maria del Carmen Sandi Perez, Johannes Gräff, Jocelin Grosse, Olivia Zanoletti, Simone Astori, Elias Georges Gebara, Jose Vicente Sanchez Mut, Catherine Maclachlan, Wei Tang, Bianca Ambrogina Silva, Alexandre Claude Gustave Bacq

Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying mechanisms, effective treatments for abnormal aggression are still missing. ...

2020

Vlogging Over Time: Longitudinal Impressions and Behavior in YouTube

Daniel Gatica-Perez, Dinesh Babu Jayagopi, Dairazalia Sanchez Cortes

YouTube vlogging, as a popular genre of ubiquitous social video, engages people in entertainment, civic, and social activities. Although several aspects of vlogging have been studied in media studies and multimedia analysis, the longitudinal angle of vlogg ...

ASSOC COMPUTING MACHINERY2018

Anderson localization of Bogoliubov excitations on quasi-1D strips

Pierre Lugan

Anderson localization of Bogoliubov excitations is studied for disordered lattice Bose gases in planar quasi-one-dimensional geometries. The inverse localization length is computed as function of energy by a numerical transfer-matrix scheme, for strips of ...

Wiley-V C H Verlag Gmbh2015

Emotional contagion for pain is intact in autism spectrum disorders

Nouchine Hadjikhani, Loyse Hippolyte, Ophélie Rogier, Torsten Ruest

Perceiving others in pain generally leads to empathic concern, consisting of both emotional and cognitive processes. Empathy deficits have been considered as an element contributing to social difficulties in individuals with autism spectrum disorders (ASD) ...

Nature Publishing Group2014

Hyper-emotional neurophysiology in a rat model of autism

Mônica Regina Favre

Autism is a pervasive neurodevelopmental disorder of unknown etiology, characterized by a spectrum of symptoms of social impairment, abnormal communication, and unusual restricted, inflexible behaviors. Patients also frequently present various levels of se ...

EPFL2013

A randomised controlled trial of bumetanide in the treatment of autism in children

Nouchine Hadjikhani

Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that like in epilepsies, GABA excites ...

Nature Publishing Group2012

The missing social instinct : behavioral and functional brain imaging investigations in autism

Nicole Regula Zürcher Wimmer

Smooth social interactions in everyday life rely on spontaneous understanding of emotions and intentions of others, conveyed by subtle social cues, such as gaze and facial expressions. In individuals with autism, however, who represent close to 1% of the p ...

EPFL2012

Investigating Gaze of Children with ASD in Naturalistic Settings

Aude Billard, Nouchine Hadjikhani, Basilio Noris

Background: Visual behavior is known to be atypical in Autism Spectrum Disorders (ASD). Monitor-based eye-tracking studies have measured several of these atypicalities in individuals with Autism. While atypical behaviors are known to be accentuated during ...

Public Library of Science2012

The intense world syndrome – an alternative hypothesis for autism

Henry Markram, Kamila Markram, Tania Rinaldi

Autism is a devastating neurodevelopmental disorder with a polygenetic predisposition that seems to be triggered by multiple environmental factors during embryonic and/or early postnatal life. While significant advances have been made in identifying the ne ...

2007

De l'effet de la polarisation électronique sur le transport de charge dans les semi-conducteurs moléculaires

Jean-David Picon

This work aims at a better understanding of transport mechanisms which take place in organic semiconductors such as pentacene. More accurately, we believe that the electronic polarization plays a leading part, which we try to identify in the particular cas ...

EPFL2006