Publications associées à Débat inné et acquis

Fast adaptation to rule switching using neuronal surprise

Wulfram Gerstner, Martin Louis Lucien Rémy Barry

In humans and animals, surprise is a physiological reaction to an unexpected event, but how surprise can be linked to plausible models of neuronal activity is an open problem. We propose a self-supervised spiking neural network model where a surprise signa ...

2024

Inter-Task Transfer of Prism Adaptation through Motor Imagery

Lisa Aïcha Mireille Julie Fleury

Prism adaptation (PA) is a useful method to investigate short-term sensorimotor plasticity. Following active exposure to prisms, individuals show consistent after-effects, probing that they have adapted to the perturbation. Whether after-effects are transf ...

MDPI2023

Tapping into Multi-Faceted Human Behavior and Psychopathology Using fMRI Brain Dynamics

Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Maria Giulia Preti, Elenor Morgenroth

Human behavior comprises many aspects that stand out by their dynamic nature. To quantify its neural underpinnings, time-resolved fMRI methods have blossomed over the past decade. In this review we conceptually organize a broad repertoire of dynamic analyt ...

2020

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity

Jacques Fellay, Gabriel Leventhal

Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as" per-parasite pathogen ...

Oxford University Press2018

A model for brain life history evolution

Timm Faulwasser, Laurent Lehmann

Complex cognition and relatively large brains are distributed across various taxa, and many primarily verbal hypotheses exist to explain such diversity. Yet, mathematical approaches formalizing verbal hypotheses would help deepen the understanding of brain ...

Public Library Science2017

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Philippe Renaud, John McKinney, Neeraj Dhar, Meltem Elitas, Rodrigo Martinez Duarte

Persistence of bacteria during antibiotic therapy is a widespread phenomenon, of particular importance in refractory mycobacterial infections such as leprosy and tuberculosis. Persistence is characterized by the phenotypic tolerance of a subpopulation of b ...

Royal Soc Chemistry2014

Models of Reward-Modulated Spike-Timing-Dependent Plasticity

Nicolas Frémaux

How do animals learn to repeat behaviors that lead to the obtention of food or other “rewarding” objects? As a biologically plausible paradigm for learning in spiking neural networks, spike-timing dependent plasticity (STDP) has been shown to perform well ...

EPFL2013

A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

Nouchine Hadjikhani, Fei Chen

Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution(1). Recent extensive genome-wide association studies (GWASs) have identified numerous si ...

2010

Reliable confidence intervals in quantitative genetics: Narrow-sense heritability

Anthony Christopher Davison

Many quantitative genetic statistics are functions of variance components, for which a large number of replicates is needed for precise estimates and reliable measures of uncertainty, on which sound interpretation depends. Moreover, in large experiments th ...

2007