Publications associées à Méninges

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

BackgroundImpaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia ...

BMC2024

Microsurgical resection of a radicular hemangioblastoma with subarachnoid hemorrhage: how I do it

Constantin Tuleasca

Background Hemangioblastomas (HBL) are benign tumors occurring sporadically or associated with Von Hippel-Lindau syndrome (VHL). Method We present the pre-, per-, and postoperative course of a rare case with radicular HBL presenting with subarachnoid hemor ...

2020

Spatiotemporal stimulation strategies in neuroprostheses to improve locomotion after spinal cord injury

Jérôme Gandar

Spinal cord injury (SCI) disrupts communication within central nervous system and lead to range of neurological disorders including paralysis. Current rehabilitation strategies to restore locomotion are poorly effective in people with severe SCI. Epidural ...

EPFL2019

Gangliosides: Treatment Avenues in Neurodegenerative Disease

Pierre Magistretti

Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative ...

FRONTIERS MEDIA SA2019

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Pierre Gérald Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...

EPFL2019

Discovery and validation of temporal patterns involved in human brain ketometabolism in cerebral microdialysis fluids of traumatic brain injury patients

Sarah Catherine Sonnay, Anirikh Chakrabarti, Nicolas Christinat, Mojgan Masoodi

Background: Traumatic brain injury (TBI) is recognized as a metabolic disease, characterized by acute cerebral glucose hypo-metabolism. Adaptive metabolic responses to TBI involve the utilization of alternative energy substrates, such as ketone bodies. Cer ...

2019

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Stéphanie Lacour, Marco Capogrosso, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Electronic dura mater soft, multimodal neural interfaces : technology, integration and implementation to surface implants

Arthur Edouard Hirsch

Neuroprosthetic devices are engineered to study, support or replace impaired functions of the nervous system. The neural interface is an essential element of neuroprosthetic systems as it allows for transduction of signals and stimuli of desired functions ...

EPFL2018

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Eduardo Martin Moraud, Tomislav Milekovic, Marco Capogrosso, Pavel Musienko, Nicolas Vachicouras, Nikolaus Wenger, Jérôme Gandar, Ivan Rusev Minev, Natalia Pavlova, Arthur Edouard Hirsch, Simone Ellen Joze Duis

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

The Impact of Spinal Cord Nerve Roots and Denticulate Ligaments on Cerebrospinal Fluid Dynamics in the Cervical Spine

Bryn Andrew Martin

Cerebrospinal fluid (CSF) dynamics in the spinal subarachnoid space (SSS) have been thought to play an important pathophysiological role in syringomyelia, Chiari I malformation (CM), and a role in intrathecal drug delivery. Yet, the impact that fine anatom ...

Public Library of Science2014

Ferritin H gene deletion in the choroid plexus and forebrain results in hydrocephalus

Patrick Fraering, Claude André Schweizer

Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine. To address the question whether ferritin H has similarly essential functions in the brain we used the Cre/loxP syste ...

Elsevier2014

A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system

Nikolaos Stergiopoulos, Philippe Reymond, Bryn Andrew Martin

Martin BA, Reymond P, Novy J, Baledent O, Stergiopulos N. A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system. Am J Physiol Heart Circ Physiol 302: H1492-H1509, 2012. First published January 20, 2012; doi: 10.1152/ajpheart.006 ...

2012

Comparison of 4D Phase-Contrast MRI Flow Measurements to Computational Fluid Dynamics Simulations of Cerebrospinal Fluid Motion in the Cervical Spine

Nikolaos Stergiopoulos, Bryn Andrew Martin

Cerebrospinal fluid (CSF) dynamics in the cervical spinal subarachnoid space (SSS) have been thought to be important to help diagnose and assess craniospinal disorders such as Chiari I malformation (CM). In this study we obtained time-resolved three direct ...

Public Library Science2012

Cerebrospinal fluid hydrodynamics in type I Chiari malformation

Bryn Andrew Martin

Purpose: The objective of this study was to review past studies that have used engineering analysis to examine cerebrospinal fluid hydrodynamics in cranial and spinal subarachnoid spaces in both healthy humans and those affected by type I Chiari malformati ...

2011

Who said fat is bad? Skull-stripping benefits from additional fat image

Tobias Kober, Delphine Ribes Lemay, Reto Meuli, Gunnar Krüger

Being a preliminary step for many clinical applications and analyses, accurate skull-stripping is a key challenge in MR brain imaging. One of its major difficulties arises from the contrast similarities at brain/non-brain tissue interfaces, in particular b ...

2011

Bio Simulation of Brain Ventricle Dilation in Normal Pressure Hydrocephalus

Kamal Shahim

Hydrocephalus is a brain disease wherein the ventricles dilate and compress the parenchyma towards the skull. It is primarily characterized by the disruption of the cerebrospinal fluid (CSF) flow within the ventricular system. Normal pressure hydrocephalus ...

EPFL2011

Spinal Subarachnoid Space Pressure Measurements in an In Vitro Spinal Stenosis Model: Implications on Syringomyelia Theories

Bryn Andrew Martin

Full explanation for the pathogenesis of syringomyelia (SM), a neuropathology characterized by the formation of a cystic cavity (syrinx) in the spinal cord (SC), has not yet been provided. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pr ...

2010

Fluid mechanics of intrathecal drug delivery

Radboud Michael Nelissen

The aim of this principally experimental study is to understand from fluid mechanic principles why an insignificant anesthetic dose administered as a short bolus into the cerebrospinal fluid inside the subarachnoid space provides greater pain relief than a ...

EPFL2008

Reduction of brain metastases in plasminogen activator inhibitor-1 deficient mice with transgenic ocular tumors

Friedrich Beermann

Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear. We studied the impact of PAI-1 deficiency in a transgenic mouse model of ocular tumors originat ...

Oxford University Press2008

Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience

Patrick Aebischer, Julien Favre

BACKGROUND: Chromaffin cells from the adrenal gland secrete a mixture of compounds that have a strong analgesic effect, especially when administered intrathecally. Many studies in animal models have shown that discordant xenogeneic cell isolates, including ...

1996