Publications associées à Exploratory data analysis

Unlabeled Principal Component Analysis and Matrix Completion

We introduce robust principal component analysis from a data matrix in which the entries of its columns have been corrupted by permutations, termed Unlabeled Principal Component Analysis (UPCA). Using algebraic geometry, we establish that UPCA is a well-de ...

Microtome Publishing2024

Autorepression of yeast Hsp70 cochaperones by intramolecular interactions involving their J-domains

Paolo De Los Rios, Satyam Tiwari, Pierre Goloubinoff, Bruno Claude Daniel Fauvet, Mathieu Rebeaud, Adélaïde Alice Mohr

The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in ne ...

Elsevier Science Inc2024

Post-correction of Historical Text Transcripts with Large Language Models: An Exploratory Study

Frédéric Kaplan, Maud Ehrmann, Matteo Romanello, Emanuela Boros, Sven-Nicolas Yoann Najem

The quality of automatic transcription of heritage documents, whether from printed, manuscripts or audio sources, has a decisive impact on the ability to search and process historical texts. Although significant progress has been made in text recognition ( ...

Association for Computational Linguistics2024

Computational drug development for membrane protein targets

Pierre Vogel, Henning Paul-Julius Stahlberg, Dongchun Ni, Babatunde Edukpe Ekundayo, Shuguang Yuan

The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep learning-driven structure prediction, increased speed and resolution of structure elucidation, machine learni ...

2024

The effects of war on Ukrainian research

Gaétan Jean A de Rassenfosse, Wolf-Hendrik Peter Uhlbach, Tetiana Murovana

The ongoing war in Ukraine has profoundly impacted the Ukrainian scientific community. Numerous researchers have either emigrated or transitioned to alternate professions. For those who remain in research, the destruction of civil infrastructure and psycho ...

Springernature2023

Toward a common standard for data and specimen provenance in life sciences

Marco Mattavelli, Anna Marsano

Open and practical exchange, dissemination, and reuse of specimens and data have become a fundamental requirement for life sciences research. The quality of the data obtained and thus the findings and knowledge derived is thus significantly influenced by t ...

WILEY2023

Timing and spatial selection bias in rapid extreme event attribution

Anthony Christopher Davison, Ophélia Mireille Anna Miralles

Selection bias may arise when data have been chosen in a way that subsequent analysis does not account for. Such bias can arise in climate event attribution studies that are performed rapidly after a devastating "trigger event'', whose occurrence correspon ...

ELSEVIER2023

Transfer learning application of self-supervised learning in ARPES

Gabriel Aeppli

There is a growing recognition that electronic band structure is a local property of materials and devices, and there is steep growth in capabilities to collect the relevant data. New photon sources, from small-laboratory-based lasers to free electron lase ...

IOP Publishing Ltd2023

Physiological Demands of Exergames in Older Adults- A Systematic Literature Review

Timo Markus Oskar Felder

New approaches are needed to address low physical activity levels among older adults and to promote daily physical activity tailored to their interests and abilities. This study aimed to review the current literature analyzing the physiological demands of ...

HUMAN KINETICS PUBL INC2023

A developmental shift in habituation to pain in human neonates

Sofia Charlotta Olhede, Laura Jones

Habituation to recurrent non-threatening or unavoidable noxious stimuli is an important aspect of adaptation to pain. Neonates, especially if preterm, are exposed to repeated noxious procedures during their clinical care. They can mount strong behavioral, ...

CELL PRESS2023

Modeling tumor size dynamics based on real-world electronic health records and image data in advanced melanoma patients receiving immunotherapy

Olivier Michielin, Federico Amato, Monia Guidi, Nadia Terranova, Daniel Abler, Alexandre Wicky

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...

2023

Multiscale pattern analysis of building replacements in Zurich from 2000 to 2019

Corentin Jean Dominique Fivet, Jingxian Ye

Building replacement (BR) – i.e., the demolition of existing structures and subsequent construction of new buildings on the same site – is often understood as a necessary urban planning strategy despite significant environmental implications regarding soli ...

2023

Fast-Spiking Interneurons of the Premotor Cortex Contribute to Initiation and Execution of Spontaneous Actions

Silvestro Micera, Maria Pasquini

Planning and execution of voluntary movement depend on the contribution of distinct classes of neurons in primary motor and premotor areas. However, timing and pattern of activation of GABAergic cells during specific motor behaviors remain only partly unde ...

SOC NEUROSCIENCE2023

Excess labile carbon promotes diazotroph abundance in heat-stressed octocorals

Claudia Isabella Pogoreutz

Nitrogen limitation is the foundation of stable coral-algal symbioses. Diazotrophs, prokaryotes capable of fixing N-2 into ammonia, support the productivity of corals in oligotrophic waters, but could contribute to the destabilization of holobiont function ...

ROYAL SOC2023

Subtleties in the trainability of quantum machine learning models

A new paradigm for data science has emerged, with quantum data, quantum models, and quantum computational devices. This field, called quantum machine learning (QML), aims to achieve a speedup over traditional machine learning for data analysis. However, it ...

SPRINGERNATURE2023

Surrogate modelling for seismic collapse risk assessment of steel moment resisting frames

Dimitrios Lignos, Andronikos Skiadopoulos, Nenad Bijelic

With the overall goal of reducing the numerical burden of uncertainty quantification involved in seismic risk assessments, this paper examines opportunities for assessment of seismic collapse capacity and risk using data-driven surrogates as a complement t ...

2023

Generating Higher-Fidelity Synthetic Datasets with Privacy Guarantees

Boi Faltings, Aleksei Triastcyn

We consider the problem of enhancing user privacy in common data analysis and machine learning development tasks, such as data annotation and inspection, by substituting the real data with samples from a generative adversarial network. We propose employing ...

MDPI2022

High-dimensional Data Cubes

Christoph Koch, Sachin Basil John

This paper introduces an approach to supporting high-dimensional data cubes at interactive query speeds and moderate storage cost. The approach is based on binary(-domain) data cubes that are judiciously partially materialized; the missing information can ...

ASSOC COMPUTING MACHINERY2022

High-dimensional Data Cubes

Christoph Koch, Sachin Basil John

This paper introduces an approach to supporting high-dimensional data cubes at interactive query speeds and moderate storage cost. The approach is based on binary(-domain) data cubes that are judiciously partially materialized; the missing information can ...

2022

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Andrew Charles Oates, Mahmut Selman Sakar, Ece Özelçi, Erik Mailand, Matthias Rüegg

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

Nature Research2022