Publications associées à Maladie du charbon

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...

EPFL2024

Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria

Tamar Kohn, Athanasios Nenes, Ghislain Gilles Jean-Michel Motos, Htet Kyi Wynn, Kalliopi Violaki, Céline Terrettaz, Aline Laetitia Schaub, Walter Hugentobler, Shannon Christa David, Laura José Costa Henriques, Daniel Scott Nolan, Marta Augugliaro

Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consortium of microorgan ...

American Society for Microbiology2024

Harnessing the Membrane Translocation Properties of AB Toxins for Therapeutic Applications

Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva

Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB ...

2021

Retention of E. coli and water on the skin after liquid contact

Tamar Kohn, Timothy R. Julian

The frequent contact people have with liquids containing pathogenic microorganisms provides opportunities for disease transmission. In this work, we quantified the transfer of bacteria—using E. coli as a model- from liquid to skin, estimated liquid retenti ...

2020

Anthrax toxin requires ZDHHC5-mediated palmitoylation of its surface-processing host enzymes

Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva

The protein acyl transferase ZDHHC5 was recently proposed to regulate trafficking in the endocytic pathway. Therefore, we explored the function of this enzyme in controlling the action of bacterial toxins. We found that ZDHHC5 activity is required for two ...

National Academy of Sciences2019

Bacterial type VI secretion system facilitates niche domination

Melanie Blokesch, Natalia Carolina Drebes Dorr

Over the last few decades humanity has experienced a series of tremendous technological advances, especially in the realm of basic science. A plethora of new approaches has allowed us to appreciate life in previously unimaginable detail, prompting the real ...

2018

Genotyping Of Bacillus Spp. Isolate Collection From Natural Samples

The aim of this study was genotyping and identification of collection of 164 Bacillus spp. isolates, from samples of soil, manure, and straw gathered from across Serbia, using Pulse field gel electrophoresis (PFGE) combined with sequencing of tuf gene, one ...

2017

Nanomechanical sensor applied to blood culture pellets: a fast approach to determine the antibiotic susceptibility against agents of bloodstream infections

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Petar Stupar

Objectives: The management of bloodstream infection, a life-threatening disease, largely relies on early detection of infecting microorganisms and accurate determination of their antibiotic susceptibility to reduce both mortality and morbidity. Recently we ...

2017

The Ins and Outs of Anthrax Toxin

Françoise Gisou van der Goot Grunberg

Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-gamma-D-glutamic a ...

Mdpi Ag2016

Folding and Endocytosis of Anthrax Toxin Receptors

Bacillus anthracis is the causative agent of the infectious disease anthrax. The disease is caused after taking up the spores by either inhalation, ingestion or through skin lesion. They then germinate inside the body and start secreting the tripartite ant ...

EPFL2016

Variability in DPA and calcium content in the spores of Clostridium species

Rizlan Bernier-Latmani, Barbora Bártová, Imrich Barak, Zuzana Chromiková, Cornelia List, Jan Jamroskovic

Spores of a number of clostridia' species, and their resistance to thermal treatment is a major concern for the food industry. Spore resistance to wet heat is related to the level of spore hydration, which is inversely correlated with the content of calciu ...

Frontiers Media SA2016

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Stewart Cole, Neeraj Dhar, Claudia Sala, Ming Zhang, Anthony Vocat

Oxazolidinones represent a new class of antituberculosis drugs that exert their function by inhibiting protein synthesis. Here, we compared the activities of three oxazolidinones, linezolid, PNU-100480, and AZD5847, against latent tuberculosis using a simp ...

Amer Soc Microbiology2014

Assessing essentiality of transketolase in Mycobacterium tuberculosis using an inducible protein degradation system

Stewart Cole, Claudia Sala, Anthony Vocat, Gaëlle Séraphine Kolly

Improved genetic tools are required to identify new drug targets in Mycobacterium tuberculosis. To this aim, genetic approaches, targeting either transcription and/or protein degradation, have been developed to appraise gene essentiality and to test the im ...

Wiley-Blackwell2014

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Lucia Brandi

Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA forms a channel that translocates LF, not only into the cytosol, but also in ...

Elsevier2013

Spatially Explicit Conditions for Waterborne Pathogen Invasion

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Lorenzo Righetto, Marino Gatto

Waterborne pathogens cause many possibly lethal human diseases. We derive the condition for pathogen invasion and subsequent disease outbreak in a territory with specific, space-inhomogeneous characteristics (hydrological, ecological, demographic, and epid ...

Univ Chicago Press2013

The dark sides of capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Julie Deuquet Ariosa

Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 ...

2012

On chip cellular dielectric spectroscopy : monitoring of glucose effect on erythrocytes membrane and analysis of the physiological role of anthrax toxin receptor in endothelial cells

Ludovica Colella

In the recent years, the development of automated systems for cellular monitoring has been highly promoted in basic biological research as well as in industries and medical diagnostic. Several methods for transduction of cellular signals have been investig ...

EPFL2012

Molecular Mechanisms Underlying Hyaline Fibromatosis Syndrome

Julie Deuquet Ariosa

Hyaline Fibromatosis Syndrome (HFS) is a rare inherited disease that is characterized by an accumulation of an unidentified hyaline material, largely affecting connective tissues. Patients afflicted with HFS present a wide range of clinical symptoms such a ...

EPFL2011

Extending the aerolysin family: from bacteria to vertebrates

Françoise Gisou van der Goot Grunberg, Mircea Ioan Iacovache

A number of bacterial virulence factors have been observed to adopt structures similar to that of aerolysin, the principal toxin of Aeromonas species. However, a comprehensive description of architecture and structure of the aerolysin-like superfamily has ...

Public Library of Science2011

Non-uraninite products of microbial U(VI) reduction

Rizlan Bernier-Latmani, Elena Suvorova Buffat, Harish Veeramani, Jonathan Sharp, Elena Cristina Dalla Vecchia, Nicholas Wigginton

A promising remediation approach to mitigate subsurface uranium contamination is the stimulation of indigenous bacteria to reduce mobile U(VI) to sparingly soluble U(IV). The product of microbial uranium reduction is often reported as the mineral uraninite ...

2010