Publications associées à Alcohol (drug)

Artificial intelligence of things for smart cities: advanced solutions for enhancing transportation safety

In the context of smart cities, ensuring road safety is crucial due to increasing urbanization and the interconnected nature of contemporary urban environments. Leveraging innovative technologies is essential to mitigate risks and create safer communities. ...

Springernature2024

Deoxygenative Transformation of Alcohols via Phosphoranyl Radical from Exogenous Radical Addition

Xile Hu, Chao Fan, Tao Xu

A general approach to the direct deoxygenative transformation of primary, secondary, and tertiary alcohols has been developed. It undergoes through phosphoranyl radical intermediates generated by the addition of exogenous iodine radical to trivalent alkoxy ...

Wiley-VCH Verlag GmbH2024

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Kristina Schoonjans, Petar Petrov

Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteristic of ...

Elsevier2024

Editing Tetrasubstituted Carbon: Dual C–O Bond Functionalization of Tertiary Alcohols Enabled by Palladium-Based Dyotropic Rearrangement

Qian Wang, Jieping Zhu, Baochao Yang, Tristan Corentin Pierre Delcaillau

Many elegant asymmetric syntheses of enantioenriched tertiary alcohols have been developed, and both the transition metal-catalyzed and the radical-based peripheral functionalization of tertiary alcohols have attracted intensive research interest in recent ...

2024

Shared functional connectome fingerprints following ritualistic ayahuasca intake

Enrico Amico, Hanna Tolle, Pablo Mallaroni

The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, whether such "fingerprints" persist under altered states of consciousness is unknown. Ayahuasca is a potent s ...

Academic Press Inc Elsevier Science2023

Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis

Michele De Palma, Nahal Mansouri

Aims: Understanding the correlations between underlying medical and personal characteristics of a patient with cancer and the risk of lung metastasis may improve clinical management and outcomes. We used machine learning methodologies to predict the risk o ...

2023

Stronger serial dependence in the depth plane than the fronto-parallel plane between realistic objects: Evidence from virtual reality

David Pascucci

Visual estimates of stimulus features are systematically biased toward the features of previously encountered stimuli. Such serial dependencies have often been linked to how the brain maintains perceptual continuity. However, serial dependence has mostly b ...

2023

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Christoph Merten, Ngoc Hien Du

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, ...

Nature Research2022

Toward Sustainable and Cost-Effective CO2 Conversion Processes to Propylene Carbonate Based on Ionic Liquids

Elia Mercedes Ruiz Pachon

The use of ionic liquids (ILs) for CO2 capture and utilization into a valuable product is attracting interest even though literature evaluating their sustainability is scarce. A liquid-liquid extraction (LLE)-based separation is recently proposed as an alt ...

WILEY-V C H VERLAG GMBH2022

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Association of neighbourhood disadvantage and individual socioeconomic position with all-cause mortality: a longitudinal multicohort analysis

Stéphane Joost, Idris Guessous

Background Few studies have examined the interactions between individual socioeconomic position and neighbourhood deprivation and the findings so far are heterogeneous. Using a large sample of diverse cohorts, we investigated the interaction effect of neig ...

ELSEVIER SCI LTD2022

Impaired cognitive flexibility and heightened urgency are associated with increased alcohol consumption in rodent models of excessive drinking

Emanuela De Falco

Alcohol use disorder (AUD) is characterized by impairments in decision-making that can exist as stable traits or transient states. Cognitive inflexibility reflects an inability to update information that guides decision-making and is thought to contribute ...

WILEY2021

Development of remote C-H bond functionalization of redox-active alcohol derivatives and oxidative transformations under photoredox catalysis

Alexandre Julien Florent Leclair

The development of radical-based remote C(sp3)-H functionalizations of redox-active alcohol derivatives, oxidative cycloaddition and rearrangement transformations under visible light photocatalysis constitute the basis of this thesis. The first chapter des ...

EPFL2021

Ten seconds of my nights: Exploring methods to measure brightness, loudness and attendance and their associations with alcohol use from video clips

Daniel Gatica-Perez, Skanda Muralidhar, Lakmal Buddika Meegahapola

Introduction Most evidence on associations between alcohol use behaviors and the characteristics of its social and physical context is based on self-reports from study participants and, thus, only account for their subjective impressions of the situation. ...

2021

Direct Photoexcitation of Ethynylbenziodoxolones: An Alternative to Photocatalysis for Alkynylation Reactions**

Jérôme Waser, Franck Le Vaillant, Stephanie Grace Elizabeth Amos, Diana Cavalli

Ethynylbenziodoxolones (EBXs) are commonly used as radical traps in photocatalytic alkynylations. Herein, we report that aryl-substituted EBX reagents can be directly activated by visible light irradiation. They act as both oxidants and radical traps, alle ...

Wiley-VCH Verlag GmbH2021

Learning Urban Nightlife Routines from Mobile Data

Daniel Gatica-Perez, Thanh Trung Phan

The use of smartphone sensing for public health studies is appealing to understand routines. We present an approach to learn nightlife routines in a smartphone sensing dataset volunteered by 184 young people (1586 weekend nights with location data captured ...

ACM2020

Understanding Eating And Drinking In Context From Crowdsourced Data

Thanh Trung Phan

With the increasing rate of urbanization, understanding food and beverage consumption, including alcohol drinking behaviour with its consequences, is relevant in such a megacity in the future. Especially, investigation of alcohol drinking is necessary for ...

EPFL2020

Youth nightlife at home: towards a feminist conceptualisation of home

Daniel Gatica-Perez, Darshan Santani

This paper explores home as a space of youth nightlife and drinking through a feminist lens. It draws on feminist geographical scholarship on home and 40 semi-structured interviews with young people aged 16–25 in Switzerland in the context of a larger inte ...

2021

Lack of effect on ambulation of dalfampridine-ER (4-AP) treatment in adult SMA patients

Brian Donal McCabe

SMA is a genetically determined motor system disorder that results in muscle weakness, selective motor neuron death, muscle atrophy, and impaired functional mobility. In SMA model systems, long-term treatment with 4-aminopyridine (4-AP) has been shown to i ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Understanding Heavy Drinking at Night through Smartphone Sensing and Active Human Engagement

Daniel Gatica-Perez, Skanda Muralidhar, Thanh Trung Phan

Heavy alcohol consumption can lead to many severe consequences. In this paper, we study the phenomenon of heavy drinking at night (4+ drinks for women or 5+ for men on a single evening), using a smartphone sensing dataset depicting about nightlife and drin ...

ACM2020