Publications associées à Ventricular zone

In vivo X-ray microtomography locally affects stem radial growth with no immediate physiological impact

Pascal Turberg, Charlotte Grossiord, Laura Mekarni, Hervé Cochard

Microcomputed tomography (mu CT) is a nondestructive X-ray imaging method used in plant physiology to visualize in situ plant tissues that enables assessments of embolized xylem vessels. Whereas evidence for X-ray-induced cellular damage has been reported, ...

Oxford Univ Press Inc2024

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Tobias Kober, Tom Hilbert, Gian Franco Piredda

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Amer Soc Neuroradiology2024

A functional model of adult dentate gyrus neurogenesis

Wulfram Gerstner, Olivia Gozel

In adult dentate gyrus neurogenesis, the link between maturation of newborn neurons and their function, such as behavioral pattern separation, has remained puzzling. By analyzing a theoretical model, we show that the switch from excitation to inhibition of ...

2021

Molecular architecture of the developing mouse brain

Gioele La Manno, Alex Russell Lederer, Irina Khven

The mammalian brain develops through a complex interplay of spatial cues generated by diffusible morphogens, cell-cell interactions and intrinsic genetic programs that result in probably more than a thousand distinct cell types. A complete understanding of ...

NATURE PORTFOLIO2021

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

Freddy Radtke

Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To ...

2018

In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag

Subashika Govindan

The tracing of neuronal cell lineages is critical to our understanding of cellular diversity in the CNS. This protocol describes a fluorescence birth-dating technique to label, track and isolate isochronic cohorts of newborn cells in the CNS in vivo in mou ...

NATURE PUBLISHING GROUP2018

Shedding of neurexin 3 beta ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons

Patrick Fraering, Erika Myrna Borcel Novoa, Mitko Dimitrov, Magda Maria Palczynska, Giorgio Ulrich, Marine Krzisch

Neurexins are transmembrane synaptic cell adhesion molecules involved in the development and maturation of neuronal synapses. In the present study, we report that Nrxn3 beta is processed by the metalloproteases ADAM10, ADAM17, and by the intramembrane-clea ...

Nature Research2016

Turbulence and zonal flow structures in the core and L-mode pedestal of tokamak plasmas

Olivier Sauter, Laurent Villard, Stephan Brunner, Trach-Minh Tran, Ben McMillan, Gabriele Merlo, Julien Stanislas Pierre Dominski

Zonal flows (ZF) play a crucial role in regulating ion temperature gradient (ITG) turbulence. In previous global gyrokinetic simulations [1] using the ORB5 code with the adiabatic electron model, it was observed that long-lived ZF structures, leading to a ...

IOP Publishing2014

Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death

Jörg Hülsken

Neurons and glia in the central nervous system originate from neural stem and progenitor cells that reside in the ventricular zones. Here we examine the role of beta-catenin in neural stem cell (NSC) regulation in mouse embryos lacking beta-catenin specifi ...

Wiley-Blackwell2011

Recruiting new neurons from the subventricular zone to the rat postnatal cortex: an organotypic slice culture model

The neurogenic subventricular zone (SVZ) of the lateral ventricle is a potential source for neuronal replacement in the postnatal or adult neocortex after injury. Here we present a novel model system to directly explore the cellular mechanisms of this proc ...

2008

Prospective identification of hematopoietic and neural stem/progenitor cells using transgenic and lentiviral based approaches

Didier Surdez

Adult stem cells represent only a minor proportion of a given tissue and are difficult to amplify in vitro without affecting their biological properties. To circumvent this problem, we used a transgenic/lentiviral based approach to isolate and characterize ...

EPFL2008

Cellular mechanisms regulating adult neurogenesis and olfactory perception in mice

Maria del Carmen Sandi Perez, Thomas Brionne

In the adult mammalian brain, neural stem cells persist in the subventricular zone and the hippocampus, producing new functional neurons throughout life. Whether and how adult neurogenesis maintains brain function remains highly debated. This question is o ...

EPFL2007

Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal

Freddy Radtke

Neural stem cells (NSCs) in the postnatal mammalian brain self-renew and are a source of neurons and glia. To date, little is known about the molecular and cellular mechanisms regulating the maintenance and differentiation of these multipotent progenitors. ...

2005

Isolation of multipotent neural precursors residing in the cortex of the adult human brain

Patrick Aebischer, Nicole Déglon

Multipotent precursors able to generate neurons, astrocytes, and oligodendrocytes have previously been isolated from human brain embryos and recently from neurogenic regions of the adult human brains. The isolation of multipotent neural precursors from adu ...

2001