Publications associées à Artère carotide interne

Reduced order modeling of parametrized pulsatile blood flows: Hematocrit percentage and heart rate

This paper numerically evaluates the accuracy and performance of a stabilized finite element Reduced Order Modelling (ROM) approach that is designed to simulate pulsatile blood flows. The method is able to estimate fluid flow parametric solutions of intere ...

PERGAMON-ELSEVIER SCIENCE LTD2023

On the similarity between aortic and carotid pressure diastolic decay: a mathematical modelling study

Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia

Aortic diastolic pressure decay (DPD) has been shown to have considerable pathophysiological relevance in the assessment of vascular health, as it is significantly affected by arterial stiffening. Nonetheless, the aortic pressure waveform is rarely availab ...

Nature Portfolio2023

A lightweight learning-based decoding algorithm for intraneural vagus nerve activity classification in pigs

Silvestro Micera, Leonardo Pollina, Ivo Strauss

Objective. Bioelectronic medicine is an emerging field that aims at developing closed-loop neuromodulation protocols for the autonomic nervous system (ANS) to treat a wide range of disorders. When designing a closed-loop protocol for real time modulation o ...

IOP Publishing Ltd2022

Adaptation and Optimization of an Intraneural Electrode to Interface with the Cervical Vagus Nerve

Silvestro Micera, Ivo Strauss

The modulation of the cervical vagus nerve (VN) using neural electrodes has shown great potential to treat cardiovascular, inflammatory, intestinal, or respiratory dysfunctions. Intraneural electrodes have shown great potentials for other neuroprosthetic a ...

IEEE2021

Multidisciplinary Approach to Treat Erectile Dysfunction

Mikaël Nils Sturny

Erectile dysfunction (ED) is a widespread disease affecting approximately 20% of men. With a rising incidence due to the global ageing of the world population, it is estimated that over 322 million patients will be affected in 2025. While not being a lifet ...

EPFL2020

A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Nikolaos Stergiopoulos, Patrick Segers

Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding n ...

2019

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

Pierre Magistretti, Jocelyne Bloch

Objectives: Lactate promotes cerebral blood flow and is an efficient substrate for the brain, particularly at times of glucose shortage. Hypertonic lactate is neuroprotective after experimental brain injury; however, human data are limited. ...

LIPPINCOTT WILLIAMS & WILKINS2018

Large eddy simulations for blood dynamics in realistic stenotic carotids

Alfio Quarteroni, Christian Vergara

In this paper, we consider large eddy simulations (LES) for human stenotic carotids in presence of atheromasic plaque, a pathological condition where transitional effects to turbulence may occur, with relevant clinical implications such as plaque rupture. ...

Wiley2017

Assessment of shear stress related parameters in the carotid bifurcation using mouse-specific FSI simulations

Bram Trachet, Patrick Segers

The ApoE(-/-) mouse is a common small animal model to study atherosclerosis, an inflammatory disease of the large and medium sized arteries such as the carotid artery. It is generally accepted that the wall shear stress, induced by the blood flow, plays a ...

Elsevier Sci Ltd2016

The influence of anesthesia and fluid-structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

Bram Trachet, Patrick Segers

Background: Low and oscillatory wall shear stresses (WSS) near aortic bifurcations have been linked to the onset of atherosclerosis. In previous work, we calculated detailed WSS patterns in the carotid bifurcation of mice using a Fluid-structure interactio ...

Elsevier Sci Ltd2016

Shear Stress Metrics and Their Relation to Atherosclerosis: An In Vivo Follow-up Study in Atherosclerotic Mice

Bram Trachet, Patrick Segers

It is generally accepted that low and oscillatory wall shear stress favors the initiation and development of atherosclerosis. However, a quantitative analysis of the association between shear stress metrics at baseline and lesion prevalence at a later stag ...

Springer Verlag2016

Vulnerable Plaque Detection and Quantification with Gold Particle-Enhanced Computed Tomography in Atherosclerotic Mouse Models

Bram Trachet, Patrick Segers

Recently, an apolipoprotein E-deficient (ApoE(-/-)) mouse model with a mutation (C1039G+/-) in the fibrillin-1 (Fbn1) gene (ApoE(-/-)Fbn1(C1039G+/-) mouse model) was developed showing vulnerable atherosclerotic plaques, prone to rupture, in contrast to the ...

B C Decker Inc2015

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Maiia Bragina, Fabiana Pereira Da Costa Fraga

Angiotensin (Ang) II contributes to the development of atherosclerosis, while Ang-(1-7) has atheroprotective actions. Accordingly, angiotensin-converting enzyme 2 (ACE2), which breaks-down Aug 11 and forms Ang-(1-7), has been suggested as a target against ...

Elsevier2015

Hyperschematia after right brain damage: a meaningful entity?

Roberta Ronchi, Giuseppe Vallar

In recent years we reported three right-brain-damaged patients, who exhibited a left-sided disprortionate expansion of drawings, both by copying and from memory, contralateral to the side of the hemispheric lesion (Neurology, 67: 1801, 2006, Neurocase 14: ...

Frontiers Research Foundation2014

The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers

Nikolaos Stergiopoulos, Bryn Andrew Martin

Continuous positive airway pressure (CPAP) is the gold standard treatment for obstructive sleep apnea. However, the physiologic impact of CPAP on cerebral blood flow (CBF) is not well established. Ultrasound can be used to estimate CBF, but there is no wid ...

Springer-Verlag2013

Time course of flow-induced adaptation of carotid artery biomechanical properties, structure and zero-stress state in the arteriovenous shunt

Nikolaos Stergiopoulos

Numerous studies have provided evidence of diameter adaptation secondary to flow-overload. but with ambiguous findings vis a vis other morphological parameters and information on the biomechanical aspects of arterial adaptation is rather incomplete. We exa ...

2012

A method for the quantification of the pressure dependent 3D collagen configuration in the arterial adventitia

Nikolaos Stergiopoulos, Jelle Tymen Christiaan Schrauwen

Collagen plays an important role in the response of the arterial wall to mechanical loading and presumably has a load-bearing function preventing overdistension. Collagen configuration is important for understanding this role, in particular in mathematical ...

Elsevier2012

Flow diversion treatment: intra-aneurismal blood flow velocity and WSS reduction are parameters to predict aneurysm thrombosis

Philippe Reymond, Luca Augsburger, Daniel Ruefenacht

To evaluate the haemodynamic changes induced by flow diversion treatment in cerebral aneurysms, resulting in thrombosis or persisting aneurysm patency over time. Eight patients with aneurysms at the para-ophthalmic segment of the internal carotid artery we ...

Springer Verlag2012

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

Rafaela Fernandes Da Silva, Jean-Christophe Copin

Aging and atherosclerosis are well-recognized risk factors for cardiac and neurovascular diseases. The Apolipoprotein E deficient (ApoE-/-) mouse on a high-fat diet is a classical model of atherosclerosis, characterized by the presence of atherosclerotic p ...

Biomed Central Ltd2012

Biomechanical, morphological and zero-stress state characterization of jugular vein remodeling in arteriovenous fistulas for hemodialysis

Nikolaos Stergiopoulos

While the role of hemodynamic variables on the development of intimal hyperplasia in arteriovenous fistulas for hemodialysis has been examined, less is known about the intramural biomechanical factors. In this study, arteriovenous fistulas were created by ...

2010