Publications associées à Syndrome d'insensibilité aux androgènes

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...

EPFL2024

Role of the androgen receptor in the human breast epithelium

Fabio De Martino

Breast cancer is the most common malignancy in women worldwide and understanding the risk factors affecting it is key for prevention. The relative risk of developing breast cancer is related to exposure to both endogenous hormones and exogenous natural and ...

EPFL2022

Towards Reliable Evaluation of Algorithms for Road Network Reconstruction from Aerial Images

Pascal Fua, Mateusz Kozinski, Leonardo Citraro

Existing connectivity-oriented performance measures rank road delineation algorithms inconsistently, which makes it difficult to decide which one is best for a given application. We show that these inconsistencies stem from design flaws that make the metri ...

2020

Statically and dynamically balanced oscillator based on Watt's linkage

Simon Nessim Henein, Hubert Pierre-Marie Benoît Schneegans, Ilan Vardi

We present a new mechanical oscillator architecture that can be made insensitive to linear and angular accelerations while keeping constant oscillation frequency. The oscillator has the kinematics of a Watt linkage, so we call it a Watt oscillator. In orde ...

EUSPEN2020

Structural basis for recognition of RALF peptides by LRX proteins during pollen tube growth

Sarah Wehrle

Plant reproduction relies on the highly regulated growth of the pollen tube for sperm delivery. This process is controlled by secreted RALF signaling peptides, which have previously been shown to be perceived by Catharanthus roseus RLK1-like (CrRLK1Ls) mem ...

National Academy of Sciences2020

Distributed forward stimulated Brillouin scattering measurement using broadband BOTDR

Luc Thévenaz, Simon Adrien Zaslawski, Zhisheng Yang, Sheng Wang

Brillouin optical time-domain reflectometry is used to perform distributed forward stimulated Brillouin scattering (FSBS) measurements. This configuration suppresses the need for an additional frequency scanning to evaluate the local Brillouin peak gain wh ...

SPIE2019

Energy and orientation independence of the channel branching in Ne* + ND3 chemi-ionisation

Andreas Osterwalder, Sean Dennis Steven Gordon

Collisions of excited neon atoms with ammonia molecules can lead to two reaction processes, dissociative ionisation and Penning ionisation. Both processes result in the ionisation of the ammonia molecule and redistribution of the electronic energy into the ...

2019

The Impact of Gender on Engineering Students' Group Work Experiences

Roland John Tormey, Siara Ruth Isaac, Prisca Aeby, Mila Vukmirovic

Women remain significantly underrepresented in engineering education, a cultural milieu which is stereotypically seen as a masculine domain. Laboratory studies and some questionnaire-based studies suggest being numerically under- or overrepresented in stud ...

Tempus Publications2019

Characterization of cancer stem cell subpopulations from patient-derived xenografts of advanced prostate cancer

Markus Germann, Marina Bice Manuela Menna

Androgen-deprivation therapy is the standard treatment for prostate cancer. Despite the initial response, a fraction of cases manifest progression to castration-resistant prostate cancer. PCa recurrence is possibly due to androgen-independent cancer stem c ...

AMER ASSOC CANCER RESEARCH2018

Sex differentiation in grayling (Salmonidae) goes through an all-male stage and is delayed in genetic males who instead grow faster

Oliver Michele Selmoni

Fish populations can be threatened by distorted sex ratios that arise during sex differentiation. Here we describe sex differentiation in a wild grayling (Thymallus thymallus) population that suffers from distorted sex ratios. We verified that sex determin ...

Springer Nature2017

EEG paradigms as a supplemental tool to behavioral assessments of DOC

José del Rocio Millán Ruiz, Serafeim Perdikis, Andrea Serino, Jean-Paul Noel

Introduction Diagnosis and prediction of recovery in the acute phase of disorders of consciousness (DOC) are critical for subsequent medical decisions. However, reliable assessment remains elusive due to the inability of current validated clinical scales t ...

2017

Bile acid-FXR alpha pathways regulate male sexual maturation in mice

Kristina Schoonjans

The bile acid receptor Farnesol-X-Receptor alpha (FRX alpha) is a member of the nuclear receptor superfamily. FRX alpha is expressed in the interstitial compartment of the adult testes, which contain the Leydig cells. In adult, short term treatment (12 hou ...

Impact Journals Llc2016

Intra- and interspecific social challenges modulate the levels of an androgen precursor in a seasonally territorial tropical damselfish

Katarina Damjanovic

Studies on different vertebrate groups have provided evidence that androgen levels in males increase after competitive social interactions during the breeding season, as postulated by the Challenge Hypothesis. However, social modulation of androgen levels ...

Academic Press Inc Elsevier Science2015

No Scope for Social Modulation of Steroid Levels in a Year-Round Territorial Damselfish

Katarina Damjanovic

Both latitude and mating system have been proposed to shape relationships between steroid hormone levels and social behavior. Recently it has been postulated that species with long lasting non-seasonal territorial behavior have low androgen responsiveness. ...

Wiley-Blackwell2015

Identification of the Link Between the Hypothalamo-Pituitary Axis and the Testicular Orphan Nuclear Receptor NR0B2 in Adult Male Mice

Kristina Schoonjans

The small heterodimer partner (SHP, nuclear receptor subfamily 0, group B, member 2; NR0B2) is an atypical nuclear receptor known mainly for its role in bile acid homeostasis in the enterohepatic tract. We previously showed that NR0B2 controls testicular f ...

Endocrine Soc2015

Bile Acids Alter Male Fertility Through G-Protein-Coupled Bile Acid Receptor 1 Signaling Pathways in Mice

Kristina Schoonjans

Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the nuclear and membrane receptors, farnesoid X receptor (FXR-alpha) and TGR ...

Wiley-Blackwell2014

The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice

Johan Auwerx, Kristina Schoonjans

Studies in rodents have shown that male sexual function can be disrupted by fetal or neonatal administration of compounds that alter endocrine homeostasis, such as the synthetic nonsteroidal estrogen diethylstilbestrol (DES). Although the molecular basis f ...

American Society for Clinical Investigation2009

Deformation transfer for detail-preserving surface editing

Mark Pauly

Recent detail-preserving shape deformation techniques are either based on a combination of multiresolution decomposition and variational bending energy minimization, or they manipulate differential coordinates and solve a Poisson system to obtain the defor ...

2006