Syndrome de libération de cytokines

Applied sciences
Génie biologique
Génie biomédical
Génie génétique

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Publications associées (26)

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumor immunity

Michele De Palma, Mario Leonardo Squadrito, Damya Laoui, Danielle Thompson, Sarah Kate Hansen

Tumour-associated macrophages (TAMs) largely express an alternatively activated (or M2) phenotype, which entails immunosuppressive and tumour-promoting capabilities. Reprogramming TAMs towards a classically activated (M1) phenotype may thwart tumour-associ ...

Nature Publishing Group2016

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation

Michele De Palma, Mario Leonardo Squadrito

MiR-511-3p is embedded in intron 5 of the CD206/MRC1 gene Mrc1, expressed by macrophage and dendritic cell populations. CD206 and miR-511-3p expression are co-regulated, and their contribution to intestinal inflammation is unclear. We investigated their ro ...

Nature Publishing Group2016

A Cationic Micelle Complex Improves CD8+T Cell Responses in Vaccination Against Unmodified Protein Antigen

Jeffrey Alan Hubbell, Davide Demurtas, Melody Swartz, Carrie Ellen Brubaker, Daniel Kenneth Bonner, Vasiliki Panagiotou

Nanoscale carrier platforms promote immune responses to vaccination by facilitating delivery of vaccine components to immunologically relevant sites. The technique is particularly valuable for subunit vaccination, in which coadministration of immunostimula ...

Amer Chemical Soc2016

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Nicola Harris, Mario Michael Zaiss, Beatrice Volpe, Ilaria Mosconi, Julia Esser-von Bieren, Lalit Kumar Dubey, Luc Xavier Marie Lebon

Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regula ...

American Society for Microbiology2015

Fabrication of a high aspect ratio (HAR) micropillar filter for a magnetic bead-based immunoassay

Martinus Gijs, Christine Ruffert

A microfluidic chip has been realized for investigating immune cell (U937) activation with lipopolysaccharide (LPS) and subsequent pro-inflammatory cytokine (Interleukin-6, IL-6) detection (Ruffert et al. Proc. EMBL Conference Microfluidics 2012a, p 184; P ...

Springer2014

A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening

Sebastian Maerkl, Jeffrey Alan Hubbell, Jose Luis Garcia Cordero, Armando Stano

Large-scale experimentation is becoming instrumental in enabling new discoveries in systems biology and personalized medicine. We developed a multiplexed high-throughput nanoimmunoassay chip capable of quantifying four biomarkers in 384 5 nL samples, for a ...

Royal Soc Chemistry2013

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