Nightshift work can negatively impact sleep, performance, and health. Careful manipulation of light exposure patterns can help reduce these negative effects but is challenging in conditions of rapidly rotating shiftwork and due to individual differences. A ...
Ray et al. (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this gen ...
American Association for the Advancement of Science2021
The circadian clock regulates diurnal variations in autonomic thermoregulatory processes such as core body temperature in humans. Thus, we might expect that similar daily fluctuations also characterize human thermal perception, the ultimate role of which i ...
Background: Population aging is posing multiple social and economic challenges to society. One such challenge is the social and economic burden related to increased health care expenditure caused by early institutionalizations. The use of modern pervasive ...
The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive tempo ...
Video Abstract Video Abstract: Theory of time delayed genetic oscillations with external noisy regulation We present a general theory of noisy genetic oscillators with externally regulated production rate and multiplicative noise. The observables that char ...
We construct reduced order models for two classes of globally coupled multi-component oscillatory systems, selected as prototype models that exhibit synchronization. These are the Kuramoto model, considered both in its original formulation and with a suita ...
