Vitamine B3

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Publications associées (26)

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Johan Auwerx, Carlos Canto Alvarez, Joanna Ratajczak

NAD(+) is a vital redox cofactor and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Supplementation with NAD(+) precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide ribosi ...

Nature Publishing Group2016

Protein acetylation in metabolism - metabolites and cofactors

Johan Auwerx, Elena Katsyuba, Hongbo Zhang, Keir Joe Menzies

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolis ...

Nature Publishing Group2016

New optical tools for non-invasive imaging and quantification of glucose and nicotinamide riboside in living cells and animals

Aleksandra Konovalova

Glucose is one of the most important metabolites that plays a key role in living organisms, as it is the primary energy source. Glucose metabolism is also an integral part in the pathogenesis of diabetes and cancer. Despite this tremendous impact of glucos ...

EPFL2016

Mitochondrial function in the brain links anxiety with social subordination

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis, Olivia Zanoletti, Michael van der Kooij, Laura Lozano Montes

Dominance hierarchies are integral aspects of social groups, yet whether personality traits may predispose individuals to a particular rank remains unclear. Here we show that trait anxiety directly influences social dominance in male outbred rats and ident ...

National Academy of Sciences2015

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Johan Auwerx, Eija Riitta Pirinen, Wei Li

Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of mitochondrial biogenesis has been proposed as an effective means to correct the biochemical defects a ...

Cell Press2014

Process for the preparation of 2-butene-1.4-diol

Albert Renken, Lioubov Kiwi, Eric Joannet

NOVELTY - A 2-butene-1,4-diol is prepared by hydrogenating 2-butyne-1,4-diol in the presence of a structured catalyst and in the absence of a solvent. USE - For preparing 2-butene-2,4-diol that is an important industrial intermediate in the preparation of ...

2005

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