Publications associées à Arthrite septique

Re-evaluating the mythical divide between traditional and novel cardiovascular risk factors in rheumatoid arthritis

Cardiovascular (CV) risk factors for rheumatoid arthritis (RA) are conventionally classified as 'traditional' and 'novel'. We argue that this classification is obsolete and potentially counterproductive. Further, we discuss problems with the common practic ...

Bmj Publishing Group2024

Can lateral tenodesis improve the rotational stability of the ACL reconstruction? A finite element analysis

Dimitar Yuriev Stanev

One of the most common knee injuries is the Anterior Cruciate Ligament (ACL) rupture with severe implications on knee stability. The usual treatment is the ACL Reconstruction (ACLR) surgery where the surgeon replaces the torn ligament with a graft in an ef ...

Public Library Science2024

Comparative RNA-Seq analyses ofDrosophilaplasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond

Drosophila melanogaster's blood cells (hemocytes) play essential roles in wound healing and are involved in clearing microbial infections. Here, we report the transcriptional changes of larval plasmatocytes after clean injury or infection with the Gram-neg ...

PUBLIC LIBRARY SCIENCE2020

Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic Imager

Hatice Altug, Filiz Yesilköy, Alexander Belushkin

New point-of-care diagnostic devices are urgently needed for rapid and accurate diagnosis, particularly in the management of life-threatening infections and sepsis, where immediate treatment is key. Sepsis is a critical condition caused by systemic respons ...

2019

The melanization reaction in Drosophila: More than black or white

Jan Paul Dudzic

The melanization reaction is a rapid and important immune mechanism in arthropods. It results in the production of melanin at the site of injury and around invading microbes. The enzymes responsible for melanogenesis are phenoloxidases (PO), which catalyze ...

EPFL2018

Inflammatory arthritis and systemic bone loss are attenuated by gastrointestinal helminth parasites

Nicola Harris, Mario Michael Zaiss, Manuel Kulagin

Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severi ...

Taylor & Francis2017

Rationalizing the In Vivo Degradation of Metal-on-Metal Artificial Hip Joints Using Tribocorrosion Concepts

Stefano Mischler, Shoufan Cao

In this study, the in vivo degradation of metal-on-metal (MoM) artificial hip joints was assessed based on the present state of the art concepts of tribocorrosion. A recently developed tribocorrosion model, based on the combination of mechanical and corros ...

Natl Assoc Corrosion Eng2017

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Sveta Chakrabarti, Xiaoxue Li, Esther Jeanne Collas

The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...

Public Library of Science2016

Tribocorrosion under fluid lubrication : modeling wear of CoCrMo artificial hip joints

Shoufan Cao

Wear is still the key problem causing the failure and limiting the lifetime of artificial hip joints, especially for the polymer acetabular cup in the metal-on-polymer and ceramic-on-polymer articulations. To reduce the wear, metal-on-metal articulation ha ...

EPFL2016

The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis

Heinrich Hofmann, Lionel André Maurizi

Background Superparamagnetic Iron Oxide Nanoparticles (SPION) are used in diagnostic imaging of a variety of different diseases. For such in-vivo application, an additional coating with a polymer, for example polyvinyl alcohol (PVA), is needed to stabilize ...

Public Library of Science2015

Structure of viral membrane-penetrating machines by electron cryo-microscopy and tomography

Sergey Nazarov

My PhD thesis aims to obtain the structure of several bacteriophages, including so-called “jumbo” phages, using the electron cryo-microscopy (cryo-EM) and to study the structural transformation of these viruses as they attach and infect the host cell. We a ...

EPFL2015

Design and integration of an instrumented knee prosthesis

Matteo Simoncini

Total knee arthroplasty is nowadays one of the most important orthopedic surgery. It consists of a procedure in which parts of the knee are replaced by a prosthesis. The largest indication for total knee arthroplasty is osteoarthritis, a knee disease that ...

EPFL2014

Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints

Georges Wagnières, Jutta Christine Wandrey, Frédéric Schmitt, Jérôme Barge, Lucienne Lagopoulos

Macrophages play key roles in inflammatory disorders. Therefore, they are targets of treatments aiming at their local destruction in inflammation sites. However, injection of low molecular mass therapeutics, including photosensitizers, in inflamed joints r ...

Elsevier2010

Long-range activation of systemic immunity through peptidoglycan diffusion in Drosophila

Bruno Lemaitre, David Welchman

The systemic immune response of Drosophila is known to be induced both by septic injury and by oral infection with certain bacteria, and is characterized by the secretion of antimicrobial peptides (AMPs) into the haemolymph. To investigate other possible r ...

2009

Thrombin-sensitive photodynamic agents: A novel strategy for selective synovectomy in rheumatoid arthritis

Hubert van den Bergh

Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensit ...

2009