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Publications associées (27)

The rate-limiting step for glucose transport into the hypothalamus is across the blood–hypothalamus interface

Rolf Gruetter, Hongxia Lei, Carole Poitry-Yamate

Specialized glucosensing neurons are present in the hypothalamus, some of which neighbor the median eminence, where the blood–brain barrier has been reported leaky. A leaky blood–brain barrier implies high tissue glucose levels and obviates a role for endo ...

Wiley-Blackwell2009

In vivo magnetic resonance studies of glycogen and hyperpolarized lithium in the rat brain

Ruud van Heeswijk

Nuclear magnetic resonance (NMR) is used for a large array of applications, ranging from chemical characterization to oil drilling to medical imaging. In these fields NMR is used as an investigational tool, but new techniques and applications are continuou ...

EPFL2009

Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness

Rolf Gruetter, Pierre Magistretti, Bernard Lanz, Jean-Marie Petit, Hanne Frenkel

Although glycogen (Glyc) is the main carbohydrate storage component, the role of Glyc in the brain during prolonged wakefulness is not clear. The aim of this study was to determine brain Glyc concentration ([]) and turnover time (tau) in euglycemic conscio ...

Elsevier2009

Non-invasive quantification of brain glycogen absolute concentration

Rolf Gruetter, Lijing Xin, Hongxia Lei, Ruud van Heeswijk, Hanne Frenkel, Sabrina Laus

The only currently available method to measure brain glycogen in vivo is C-13 NMR spectroscopy. Incorporation of C-13-labeled glucose (Glc) is necessary to allow glycogen measurement, but might be affected by turnover changes. Our aim was to measure glycog ...

Wiley-Blackwell2008

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types

Friedrich Beermann, Anne Grapin-Botton

All pancreatic endocrine cells, producing glucagon, insulin, somatostatin, or PP, differentiate from Pdx1+ progenitors that transiently express Neurogenin3. To understand whether the competence of pancreatic progenitors changes over time, we generated tran ...

Cell Press - Elsevier2007

Biochemical quantification of total brain glycogen concentration in rats under different glycemic states

Rolf Gruetter

All 13C NMR studies of brain glycogen to date relied on observing the incorporation of 13C label into glycogen, and thus interpretation was potentially affected by changes in 13C label turnover rates. The goal of this study was to quantify total brain glyc ...

Elsevier2006

Glucose sensitivity through oxidation responsiveness. An example of cascade-responsive nano-sensors

Jeffrey Alan Hubbell, Nicola Tirelli, Annemie Rehor

Oxidn.-sensitive nanoparticles have been decorated with an oxidizing enzyme (glucose oxidase) for release behavior that is responsive to the presence of the enzyme substrate (glucose). [on SciFinder (R)] ...

Royal Society of Chemistry2005

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