Publications associées à Vibrio vulnificus

Genome sequences of Vibrio cholerae strains isolated in the DRC between 2009 and 2012

Melanie Blokesch, Sandrine Stutzmann, Alexandre Lemopoulos, Natalia Carolina Drebes Dorr

Vibrio cholerae has caused seven cholera pandemics in the past two centuries. The seventh and ongoing pandemic has been particularly severe on the African continent. Here, we report long read-based genome sequences of six V. cholerae strains isolated in th ...

2024

Dangerous acquaintances: the interplay between type IV pili and the type VI secretion system during Vibrio cholerae's environmental lifestyle

Simon Bernhard Otto

Cholera, caused by the bacterium Vibrio cholerae, has affected humanity throughout history and still impacts millions of people every year. Apart from being a human pathogen, V. cholerae is a common member of the aquatic environment. Due to this natural re ...

EPFL2024

Sporadic type VI secretion in seventh pandemic Vibrio cholerae

Melanie Blokesch, Sandrine Stutzmann, Nicolas René Chiaruttini, Alexis Joseph Proutière, Loriane Bader, Lisa Christina Metzger, Natalia Carolina Drebes Dorr, Sandrine Natacha Isaac

Vibrio cholerae is a pathogen that causes disease in millions of people every year by colonizing the small intestine and then secreting the potent cholera toxin. How the pathogen overcomes the colonization barrier created by the host’s natural microbiota i ...

2023

How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior

Leonardo Filipe Lemos Rocha

The bacterium Vibrio cholerae is the causative agent of the diarrheal disease cholera, which affects millions of people every year. Apart from being a human pathogen, V. cholerae is also a common member of aquatic habitats. Whilst the mechanism that allow ...

EPFL2022

Thermal Stress Interacts With Surgeonfish Feces to Increase Coral Susceptibility to Dysbiosis and Reduce Tissue Regeneration

Leïla Ezzat

Dysbiosis of coral microbiomes results from various biotic and environmental stressors, including interactions with important reef fishes which may act as vectors of opportunistic microbes via deposition of fecal material. Additionally, elevated sea surfac ...

Frontiers Media SA2021

The molecular treasure box of environmental Vibrio cholerae strains

Natalia Carolina Drebes Dorr

Cholera pandemics have been affecting humankind for centuries and are still considered a major public health problem, especially in regions around the world with poor access to clean water and sanitation. Cholera pandemics are caused by a specific lineage ...

EPFL2021

Two nanomachines drive evolution in diverse Vibrio species

Noémie Matthey

Horizontal gene transfer (HGT) has a major impact on bacterial evolution, leading to acquisition or deletion of genes and gene clusters, including those encoding antibiotic resistances and virulence factors. HGT therefore contributes to pathogen emergence, ...

EPFL2019

Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions

Graham Knott, Melanie Blokesch, Sandrine Stutzmann, Candice Stoudmann, Catherine Maclachlan, Natalia Carolina Drebes Dorr, Charles Ulric V Van der Henst, Tiziana Scrignari, Audrey Sophie Vanhove

Vibrio cholerae, which causes the diarrheal disease cholera, is a species of bacteria commonlyfound in aquatic habitats. Within such environments, the bacterium must defend itselfagainst predatory protozoan grazers. Amoebae are prominent grazers, withAcant ...

Nature Research2018

Eco-Evolutionary Dynamics Linked to Horizontal Gene Transfer in Vibrios

Melanie Blokesch, Frédérique Marie Jeanne Le Roux

Vibrio is a genus of ubiquitous heterotrophic bacteria found in aquatic environments. Although they are a small percentage of the bacteria in these environments, vibrios can predominate during blooms. Vibrios also play important roles in the degradation of ...

2018

Bacterial type VI secretion system facilitates niche domination

Melanie Blokesch, Natalia Carolina Drebes Dorr

Over the last few decades humanity has experienced a series of tremendous technological advances, especially in the realm of basic science. A plethora of new approaches has allowed us to appreciate life in previously unimaginable detail, prompting the real ...

2018

Visualizing chemical transport from extracellular symbionts into squid host tissues using NanoSIMS

Stéphanie Kéren Cohen

Chemical communication is the basis of host-microbe interaction. Insights into this communication will provide a deeper understanding of the mechanisms that govern these complex associations, in beneficial as well as pathogenic contexts. In this dissertati ...

EPFL2017

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY

Melanie Blokesch, Sandrine Stutzmann, Noémie Matthey, Lisa Christina Metzger, Tiziana Scrignari, Charles Ulric V Van der Henst

Type VI secretion systems (T6SSs) are nanomachines used for interbacterial killing and intoxication of eukaryotes. Although Vibrio cholerae is a model organism for structural studies on T6SSs, the underlying regulatory network is less understood. A recent ...

Elsevier2016

Circulation of a Quorum-Sensing-Impaired Variant of Vibrio cholerae Strain C6706 Masks Important Phenotypes

Melanie Blokesch, Sandrine Stutzmann

Vibrio cholerae, the causative agent of cholera, is a model organism for studying virulence regulation, biofilm formation, horizontal gene transfer, and the cell-to-cell communication known as quorum sensing (QS). As in any research field, discrepancies be ...

Amer Soc Microbiology2016

On the probability of extinction of the Haiti cholera epidemic

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Flavio Finger, Marino Gatto

More than three years after its appearance in Haiti, cholera has already caused more than 8,500 deaths and 695,000 infections and it is feared to become endemic. However, no clear evidence of a stable environmental reservoir of pathogenic Vibrio cholerae, ...

Springer Verlag2016

Regulation of competence-mediated horizontal gene transfer in the natural habitat of Vibrio cholerae

Melanie Blokesch, Lisa Christina Metzger

The human pathogen Vibrio cholerae is an autochthonous inhabitant of aquatic environments where it often interacts with zooplankton and their chitinous molts. Chitin induces natural competence for transformation in V. cholerae, a key mode of horizontal gen ...

Elsevier2016

The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11–12th March 2015)

Melanie Blokesch, Frédérique Marie Jeanne Le Roux

Global change has caused a worldwide increase in reports of Vibrio-associated diseases with ecosystem-wide impacts on humans and marine animals. In Europe, higher prevalence of human infections followed regional climatic trends with outbreaks occurring dur ...

Frontiers Media SA2015

Competence-induced type VI secretion might foster intestinal colonization by Vibrio cholerae

Melanie Blokesch

The human pathogen Vibrio cholerae exhibits two distinct lifestyles: one in the aquatic environment where it often associates with chitinous surfaces and the other as the causative agent of the disease cholera. While much of the research on V. cholerae has ...

Wiley-Blackwell2015

An intracellular replication niche for Vibrio cholerae in the amoeba Acanthamoeba castellanii

Melanie Blokesch, Catherine Maclachlan, Tiziana Scrignari, Charles Ulric V Van der Henst

Vibrio cholerae is a human pathogen and the causative agent of cholera. The persistence of this bacterium in aquatic environments is a key epidemiological concern, as cholera is transmitted through contaminated water. Predatory protists, such as amoebae, a ...

Nature Publishing Group2015

Hydrological, Anthropogenic and Ecological Processes in Cholera Dynamics

Lorenzo Righetto

The present Thesis deals with understanding, measuring and modelling epidemic cholera. The relevance of the endeavour stems from the fact that mathematical epidemiology, properly guided by model-guided field validation, is a reliable and powerful tool to m ...

EPFL2013

Chitin colonization, chitin degradation and chitin-induced natural competence of Vibrio cholerae are subject to catabolite repression

Melanie Blokesch

Although Vibrio cholerae is a human pathogen its primary habitat are aquatic environments. In this environment, V. cholerae takes advantage of the abundance of zooplankton, whose chitinous exoskeletons provide a nutritious surface. Chitin also induces the ...

Wiley-Blackwell2012