Publications associées à Gonadal dysgenesis

Functional kleptoplasts intermediate incorporation of carbon and nitrogen in cells of the Sacoglossa sea slug Elysia viridis

Anders Meibom, Stéphane Laurent Escrig, Charlotte Madeleine Nicole Lekieffre, Michael Kühl

Some sacoglossan sea slugs incorporate intracellular functional algal chloroplasts, a process termed kleptoplasty. "Stolen" chloroplasts (kleptoplasts) can remain photosynthetically active up to several months, contributing to animal nutrition. Whether thi ...

Nature Research2020

Sex-specific changes in gene expression in response to estrogen pollution around the onset of sex differentiation in grayling (Salmonidae)

Oliver Michele Selmoni

The synthetic 17 alpha-ethinylestradiol (EE2) is a common estrogenic pollutant that has been suspected to affect the demography of river-dwelling salmonids. One possibility is that exposure to EE2 tips the balance during initial steps of sex differentiatio ...

2019

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

Pierre Gönczy, Alexandra Bezler, Frédéric Schütz, Laurent Keller, Raffaella Conconi

RNA interference (RNAi) related pathways are essential for germline development and fertility in metazoa and can contribute to inter- and trans-generational inheritance. In the nematode Caenorhabditis elegans, environmental double-stranded RNA provided by ...

2019

Sex differentiation in grayling (Salmonidae) goes through an all-male stage and is delayed in genetic males who instead grow faster

Oliver Michele Selmoni

Fish populations can be threatened by distorted sex ratios that arise during sex differentiation. Here we describe sex differentiation in a wild grayling (Thymallus thymallus) population that suffers from distorted sex ratios. We verified that sex determin ...

Springer Nature2017

Cell Cycle-Dependent Differentiation Dynamics Balances Growth and Endocrine Differentiation in the Pancreas

Anne Grapin-Botton, Laurence Anne E Lemaire, Yung Hae Kim

Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can ...

Public Library Science2015

Progesterone and Overlooked Endocrine Pathways in Breast Cancer Pathogenesis

Cathrin Brisken, Kathryn Hess Bellwald, Rachel Marcone

Worldwide, breast cancer incidence has been increasing for decades. Exposure to reproductive hormones, as occurs with recurrent menstrual cycles, affects breast cancer risk, and can promote disease progression. Exogenous hormones and endocrine disruptors h ...

2015

An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging

Johan Auwerx, Martinus Gijs, Thomas Lehnert, Matteo Cornaglia, Laurent Mouchiroud, Alexis Pierre Henri Marette, Virginija Jovaisaite, Shreya Narasimhan

Studies of the real-time dynamics of embryonic development require a gentle embryo handling method, the possibility of long-term live imaging during the complete embryogenesis, as well as of parallelization providing a population's statistics, while keepin ...

Nature Publishing Group2015

Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility

Alexandre Gattiker

Mammalian spermatogenesis is a process that involves a complex expression program in both somatic and germ cells present in the male gonad. A number of studies have attempted to define the transcriptome of male meiosis and gametogenesis in rodents and prim ...

Oxford University Press2012

Slip in directionally solidified Mo-alloy micropillars-Part II: Pillars containing defects

Helena Van Swygenhoven, Steven Van Petegem, Camelia Borca

In situ Laue analysis during microcompression is carried out on Mo-alloy pillars containing defects due to focused ion beam milling or pre-strain. Independently of how the defects are introduced, if the diffraction peaks are streaked prior to deformation, ...

2012

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Mathieu Gouzi

The pancreas is one of the major organs of the digestive tract. Its endocrine function, mainly regulating glucose blood level, is achieved by endocrine cells. These cells are organized in clusters, the so-called islets of Langerhans. During development, th ...

EPFL2010