Concept

Ostéoclaste

Publications associées (17)

Effect of minor amounts of beta-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of beta-tricalcium phosphate cylinders

Paul Bowen, Gabrielle Anne Laguisma Sblendorio

beta-Tricalcium Phosphate (beta-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include beta-calcium pyrophosphate (beta-CPP) and hydroxyapatite (HA). Currently, the ef ...

KEAI PUBLISHING LTD2022

From the product to the process: Fine-scale skeletal structures of scleractinian corals and their relevance to biomineralization models, geochemical sampling strategies, and phylogenetic reconstructions

Anders Meibom, Jaroslaw Hubert Stolarski

Interpretation of biomineralization processes based solely on the end product - the skeleton - may seem abreakneck task. This is because the biologically controlled mineralization involves cascades of intermediatephases and the activity of a myriad of orga ...

2019

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Treatment with sulphated galactan inhibits macrophage chemotaxis and reduces intraplaque macrophage content in atherosclerotic mice

Nikolaos Stergiopoulos

Experimental data from animal models and clinical studies support connections between the haemostasis and inflammation in atherogenesis. These interfaces among inflammation and thrombogenesis have been suggested as targets for pharmacological intervention ...

Elsevier Science Inc2015

Differential Roles of MAPK Kinases MKK3 and MKK6 in Osteoclastogenesis and Bone Loss

Mario Michael Zaiss

Bone mass is maintained by osteoclasts that resorb bone and osteoblasts that promote matrix deposition and mineralization. Bone homeostasis is altered in chronic inflammation as well as in post-menopausal loss of estrogen, which favors osteoclast activity ...

Public Library of Science2014

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Mario Michael Zaiss, Zhen Chen

Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mechanism o ...

Amer Assoc Advancement Science2014

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Tamara Tanos, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2-(methacryloyloxy)ethyl phosphate) brushes

Harm-Anton Klok, Dusko Paripovic

Modification of bone implant materials with biofunctional surfaces that facilitate osteoblast adhesion and promote matrix mineralization is an attractive strategy to improve osseointegration. This manuscript discusses the preparation and properties of RGD ...

Royal Society of Chemistry2012

68Ga-NODAGA-RGDyK for αvβ3 integrin PET imaging. Preclinical investigation and dosimetry

Carole Poitry-Yamate, Christian Rüegg, Serge Baechler, David Viertl

To visualize neovasculature and/or tumour integrin αvβ3 we selected the binding moiety Arg-Gly-Asp-D-Tyr-Lys (RGDyK) coupled to NODAGA for labeling with 68Ga. ...

Schattauer2011

Bioresorbable Nanocomposite Foams for Bone Tissue Engineering

Claire Diane Delabarde

The present work forms part of an ongoing effort at the Laboratory of Polymer and Composite Technology (LTC) to develop novel solvent-free processing methods for next generation resorbable porous scaffolds for bone replacement, based on supercritical carbo ...

EPFL2011

Targeted mechanical properties for optimal fluid motion inside artificial bone substitutes

Dominique Pioletti, Alexandre Terrier, Lalaonirina Rakotomanana Ravelonarivo, Luc Blecha

The goal of this study was to develop a method that identifies optimal elastic modulus, Poisson’s ratio, porosity and permeability values for mechanically stressed bone substitute. It was hypothesized that porous bone substitute that favors the transport o ...

2009

Prediction of bone density around orthopedic implants delivering bisphosphonate

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

The fixation of an orthopedic implant depends strongly upon its initial stability. Peri-implant bone may resorb shortly after the surgery. This resorbtion is directly followed by new bone formation and implants fixation strengthening, the so-called seconda ...

2009

Notch Inhibits Osteoblast Differentiation And Causes Osteopenia

Freddy Radtke

Notch receptors are determinants of cell fate decisions. To define the role of Notch in the adult skeleton, we created transgenic mice overexpressing the Notch intracellular domain (NICD) under the control of the type I collagen promoter. First generation ...

2008

Epidermal Receptor Activator of NF-{kappa}B Ligand Controls Langerhans Cells Numbers and Proliferation

Cathrin Brisken

Langerhans cells (LC) are the dendritic APC population of the epidermis, where they reside for long periods and are self-replicating. The molecular signals underlying these characteristics are unknown. The TNF superfamily member receptor activator of NF-ka ...

American Association of Immunologists ; Oxford University Press2008

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta, Lee Ann Laurent-Applegate, Claire Diane Delabarde

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

2008

Fetal bone cells for tissue engineering

In this thesis, the potential use of fetal bone cells for tissue engineering was evaluated. At first, fetal bone cells were characterized in vitro regarding their proliferation rate, the induction of their osteoblastic phenotype, and their antigenicity. Th ...

EPFL2007