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Publications associées (31)

Plasma and liver lipid species as biomarkers of fatty liver

Johan Auwerx, Pooja Jha

The invention relates to plasma or liver lipid species selected from the triacylglycerol (TAG) and cardiolipin (CL) lipid classes measured by LC-MS/MS and use thereof as diagnostic and prognostic biomarkers of fatty liver, as well as to monitor the efficac ...

2018

Hydro-mechanical characterization of gas shales and Opalinus Clay shale in partially saturated conditions

Alberto Minardi

An experimental study on the behaviour of shales in partially water saturated conditions is presented in this thesis. The Opalinus Clay shale and gas shales from different unconventional reservoirs have been studied. Opalinus Clay is currently considered a ...

EPFL2018

Frictional and transport properties of faults zones in the Opalinus Clay formation

Luis Felipe Orellana Espinoza

Deep geological repositories in clay formations are a promising option to ensure the long-term isolation of nuclear waste from the population and the environment. In Switzerland, the Opalinus Clay (OPA) formation is a shale whose favorable barrier properti ...

EPFL2018

Nonlinear elastic response of partially saturated gas shales in uniaxial compression

Lyesse Laloui, Alessio Ferrari, Alberto Minardi

Elastic properties of gas shales are fundamental for the geomechanical characterization of unconventional reservoirs. Due to the presence of microcracks, a non-linear elastic behaviour with hysteresis is usually exhibited when gas shales are subjected to u ...

2018

Microcomputed Tomography Technique for In Vivo Three-Dimensional Fat Tissue Volume Evaluation After Polymer Injection

Harm-Anton Klok, Ioana Konz

Tissue engineering technologies are new and promising techniques in fat tissue reconstruction. However, to assess their efficacy before any clinical application, in vivo experiments are mandatory. This study assesses whether microcomputed tomography (CT) s ...

2017

Fluorinated and Charged Hydrogenated Alkanethiolates Grafted on Gold: Expanding the Diversity of Mixed-Monolayer Nanoparticles for Biological Applications

Francesco Stellacci

Low intrinsic toxicity, high solubility, and stability are important and necessary features of gold nanoparticles to be used in the biomedical field. In this context, charged nanoparticles proved to be very versatile, and among them charged mixed-monolayer ...

American Chemical Society2017

Surviving anoxia in marine sediments: The metabolic response of ubiquitous benthic foraminifera (Ammonia tepida)

Anders Meibom, Stéphane Laurent Escrig, Charlotte Madeleine Nicole Lekieffre, Emmanuelle Geslin

High input of organic carbon and/or slowly renewing bottom waters frequently create periods with low dissolved oxygen concentrations on continental shelves and in coastal areas; such events can have strong impacts on benthic ecosystems. Among the meiofauna ...

Public Library of Science2017

The role of nicotinamide riboside kinases in mammalian NAD⁺ metabolism

Joanna Ratajczak

NAD+ has emerged as a central metabolic node and an important co-substrate for the activity of various enzymes, including the protein deacetylase SIRT1. Different strategies to increase NAD+ bioavailability have been shown to boost SIRT1 activity, which re ...

EPFL2017

Optimizing the acceleration and resolution of three-dimensional fat image navigators for high-resolution motion correction at 7T

José Pedro Rebelo Ferreira Marques, Daniel Gallichan

PURPOSE: To investigate the effect of spatial resolution and parallel imaging acceleration factor on the quality of the motion estimates derived from image navigators with a three-dimensional (3D) gradient-recalled echo (GRE) acquisition with fat excitatio ...

Wiley-Blackwell2017

Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens

Bart Deplancke

The regulation of gene expression controls development, and changes in this regulation often contribute to phenotypic evolution. Drosophila pigmentation is a model system for studying evolutionary changes in gene regulation, with differences in expression ...

Genetics Society of America2016

A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria

Matteo Dal Peraro, John McKinney, Florence Pojer, Giulia Fonti, Paul Murima, Tarun Chopra

Fatty acid metabolism is an important feature of the pathogenicity of Mycobacterium tuberculosis during infection. Consumption of fatty acids requires regulation of carbon flux bifurcation between the oxidative TCA cycle and the glyoxylate shunt. In Escher ...

Nature Publishing Group2016

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