Concept

Frontotemporal dementia

Publications associées (28)

Differentiating Parkinson's disease motor subtypes using automated volume-based morphometry incorporating white matter and deep gray nuclear lesion load

Background Periventricular leukoaraiosis may be an important pathological change in postural instability gait disorder (PIGD), a motor subtype of Parkinson's disease (PD). Clinical diagnosis of PIGD may be challenging for the general neurologist. Purpose T ...

2020

Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States

Hilal Lashuel, Mahmood Haj Yahya

The microtubule-associated protein Tau plays a central role in neurodegeneration and is a leading therapeutic target for the treatment of Alzheimer’s disease (AD). Several lines of evidence suggest that post-translational modifications (PTMs) regulate the ...

2018

Self-grounded vision: hand ownership modulates visual location through cortical beta and gamma oscillations

Olaf Blanke, Fosco Bernasconi, Roy Salomon, Herberto Dhanis Pedro De Barros Camacho, Nathan Quentin Faivre, Javier Bello Ruiz, Michele Scandola

Vision is known to be shaped by context, defined by environmental and bodily signals. In the Taylor illusion, the size of an afterimage projected on one's hand changes according to proprioceptive signals conveying hand position. Here, we assessed whether t ...

2017

Gastro-intestinal biomarkers for diagnosis and therapies of proteinopathies

Theo Lasser, Tristan Bolmont, Taoufiq Harach

Pharmaceutical composition for the treatment of proteinopathies comprising products which are able to stimulate growth or inhibition of at least one of Odoribacter, Oscillospira, Dehalobacterium, Alistipes, Parabacteroides, Lactobacillus and Sutterella, Fi ...

2016

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

Maurizio Molinari

Only native polypeptides are released from the endoplasmic reticulum (ER) to be transported at the site of activity. Persistently misfolded proteins are retained and eventually selected for ER-associated degradation (ERAD). The paradox of a structure-based ...

Amer Soc Cell Biology2015

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic understanding is still lacking. However, neurodegenerative diseases such as Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) al ...

Bentham Science Publishers2015

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Patrick Aebischer, Bernard Schneider

Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate the hypothesis that reactivation of plasticity can restore function in the presence of neuronal damage resulting from tauopathy. We investigated two models with tau h ...

2015

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

João Miguel das Neves Duarte

From epidemiological studies it is known that diabetes patients display increased risk of developing dementia. Moreover, cognitive impairment and Alzheimer's disease (AD) are also accompanied by impaired glucose homeostasis and insulin signalling. Although ...

Int Soc Aging & Disease2015