Concept

Graft (surgery)

Publications associées (14)

Compliance-matching vascular grafts with personalization potential

Aortic diseases are characterized by dire prognosis and inadequate diagnosis, owing to their insidious yet lethal nature. Aortopathies, namely aortic aneurysms and dissections, along with certain congenital diseases, might necessitate surgical replacement ...

EPFL2023

A Review on Finite Element Modeling and Simulation of the Anterior Cruciate Ligament Reconstruction

Dimitar Yuriev Stanev

The anterior cruciate ligament (ACL) constitutes one of the most important stabilizing tissues of the knee joint whose rapture is very prevalent. ACL reconstruction (ACLR) from a graft is a surgery which yields the best outcome. Taking into account the com ...

FRONTIERS MEDIA SA2020

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Scaffold requirements for periodontal regeneration with enamel matrix derivative proteins

John Christopher Plummer, Laurent Mirko Dejace, Matteo Gregorio Modesto Marascio, Alessandra Apicella, Peter Fischer

Periodontitis affects the attachment of natural teeth, and infection or inflammation associated with periodontitis may affect peri-implant tissues. Enamel matrix derivative (EMD) proteins provide stimulation for self-regeneration of the damaged tissue when ...

Elsevier Science Bv2017

Caspofungin on ARGET-ATRP grafted PHEMA polymers: Enhancement and selectivity of prevention of attachment of Candida albicans

Harm-Anton Klok, Piotr Mocny

There is a need for coatings for biomedical devices and implants that can prevent the attachment of fungal pathogens while allowing human cells and tissue to appose without cytotoxicity. Here, the authors study whether a poly(2-hydroxyethylmethacrylate) (P ...

2017

Fabrication of thermo-responsive nano-valve by grafting-to in melt of poly(N-isopropylacrylamide) onto nanoporous silicon nitride membranes

Philippe Renaud, Alexandre Zenon Ivan Bojko, Raphaël Pugin, Franck Montagne

This article reports the grafting-to in melt of amino and carboxy-terminated poly(N-isopropylacrylamide) (PNIPAM) onto ultrathin nanoporous silicon nitride membranes (NSiNMs) with a mean pore size of 85 +/- 15 nm functionalized respectively with a self-ass ...

Elsevier2014

Advances in the design of macroporous polymer scaffolds for potential applications in dentistry

Philippe Renaud, Thomas Michael Braschler, Sidi Ahmed Bencherif

A paradigm shift is taking place in medicine and dentistry from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous three-dimensional (3D) material hydrogels integrated with cells and bioactive factors to ...

2013

Biomechanical, morphological and zero-stress state characterization of jugular vein remodeling in arteriovenous fistulas for hemodialysis

Nikolaos Stergiopoulos

While the role of hemodynamic variables on the development of intimal hyperplasia in arteriovenous fistulas for hemodialysis has been examined, less is known about the intramural biomechanical factors. In this study, arteriovenous fistulas were created by ...

2010

Bone healing induced by local delivery of an engineered parathyroid hormone prodrug

Jeffrey Alan Hubbell

Regenerative medicine requires innovative therapeutic designs to accommodate high morphogen concentrations in local depots, provide their sustained presence, and enhance cellular invasion and directed differentiation. Here we present an example for inducin ...

2009

Theroretical and experimental multi-scale study of an artificial bone construct : from tibial osteotomy to cell/fluid interaction

Luc Blecha

Synthetic bone substitutes are potentially the future gold standard in orthopaedic and traumatologic surgery. The availability of these bone substitutes with different biomechanical properties may well replace autografts in the future as they overcome comp ...

EPFL2007

Architecture and properties of anisotropic polymer composite scaffolds for bone tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban

Bone is a complex porous composite structure with specific characteristics such as viscoelasticity and anisotropy, both in morphology and mechanical properties. Bone defects are regularly filled with artificial tissue grafts, which should ideally have prop ...

2006

Protein-functionalized polymer brushes

Kai Johnsson, Harm-Anton Klok, Anke Arnold, Stefano Tugulu, India Christina Sielaff

Understanding and controlling the interactions between synthetic and biol. materials is of great importance for the development of novel materials for a variety of biomedical and bioanal. applications, including for example stents, vascular grafts and prot ...

2005

Allogeneic beta-islet cells correct diabetes and resist immune rejection

Patrick Aebischer

Allogeneic MHC-incompatible organ or cell grafts are usually promptly rejected by immunocompetent hosts. Here we tested allogeneic beta-islet cell graft acceptance by immune or naive C57BL/6 mice rendered diabetic with streptozotocin (STZ). Fully MHC-misma ...

National Academy of Sciences2002

Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia

Patrick Aebischer

Stimulating angiogenesis by gene transfer approaches offers the hope of treating tissue ischemia which is untreatable by currently practiced techniques of vessel grafting and bypass surgery. Vascular endothelial growth factor (VEGF) and basic fibroblast gr ...

2001