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Arnaud Comment

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Publications associées (110)

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR

Arnaud Comment, Paul Romeo Vasos, Riccardo Balzan

The main limitation of NMR-based investigations is low sensitivity. This prompts for long acquisition times, thus preventing real-time NMR measurements of metabolic transformations. Hyperpolarization via dissolution DNP circumvents part of the sensitivity ...

Journal Of Visualized Experiments2016

Dissolution DNP for in vivo preclinical studies

Arnaud Comment

The tremendous polarization enhancement afforded by dissolution dynamic nuclear polarization (DNP) can be taken advantage of to perform preclinical in vivo molecular and metabolic imaging. Following the injection of molecules that are hyperpolarized via di ...

Academic Press Inc - Elsevier Science2016

Overhauser-enhanced magnetic resonance elastography

Arnaud Comment, Najat Salameh

Magnetic resonance elastography (MRE) is a powerful technique to assess the mechanical properties of living tissue. However, it suffers from reduced sensitivity in regions with short T-2 and T-2* such as in tissue with high concentrations of paramagnetic i ...

Wiley-Blackwell2016

En route to ion microprobe analysis of soluble compounds at single cell level: The CryoNanoSIMS

Arnaud Comment, Tian Cheng, Anders Meibom, Stéphane Laurent Escrig, Florent Olivier Vivien Plane, Louise Helene Soegaard Jensen

2016

Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri

Arnaud Comment, Christophe Roussel, Tim Rolf Eichhorn

A method for the preparation of a sample comprising highly polarized nuclear spins is proposed, comprising at least the following steps: a) provision of molecules with 1,2-dione structural units and/or molecules with 2,5-diene-1,4-dione structural units in ...

2016

Realization of sub-cellular resolution cryogenic ion microprobeimaging with vitrified samples

Arnaud Comment, Tian Cheng, Anders Meibom, Stéphane Laurent Escrig, Florent Olivier Vivien Plane, Louise Helene Soegaard Jensen

2016

Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel

Arnaud Comment, Mor-Miri Mishkovsky, Tian Cheng

Dissolution dynamic nuclear polarization (DNP) provides a way to tremendously improve the sensitivity of nuclear magnetic resonance experiments. Once the spins are hyperpolarized by dissolution DNP, the radicals used as polarizing agents become undesirable ...

Wiley-Blackwell2016

Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate

Arnaud Comment, Josefina Adriana Maria Bastiaansen

Cardiac dysfunction is often associated with a shift in substrate preference for ATP production. Hyperpolarized (HP) (13)C magnetic resonance spectroscopy (MRS) has the unique ability to detect real-time metabolic changes in vivo due to its high sensitivit ...

Nature Research2016

Myocardial fatty acid metabolism probed with hyperpolarized [1-13C]octanoate

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara

2015

Assessing ischemic myocardial metabolism in vivo with hyperpolarized 13C: relating the metabolic perturbation to the area at risk

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara

Taylor & Francis2015

Optimal Glass-Forming Solvent Brings Sublimation Dynamic Nuclear Polarization to 129Xe Hyperpolarization Biomedical Imaging Standards

Arnaud Comment, Christophe Roussel, Jean-Noël Hyacinthe, Andrea Capozzi

In addition to the dedicated spin exchange optical pumping (SEOP) technique, an alternative method to produce hyperpolarized xenon gas using dynamic nuclear polarization (DNP) followed by a sublimation procedure was proposed. The challenge associated with ...

American Chemical Society2015

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose

Arnaud Comment, Graham Knott, Yuhei Takado, Anders Meibom, Stéphane Laurent Escrig, Mojgan Masoodi

Glucose is the primary source of energy for the brain but also an important source of building blocks for proteins, lipids, and nucleic acids. Little is known about the use of glucose for biosynthesis in tissues at the cellular level. We demonstrate that l ...

Elsevier2015

Imaging liver and brain glycogen metabolism at the nanometer scale

Arnaud Comment, Graham Knott, Yuhei Takado, Anders Meibom, Stéphane Laurent Escrig, Mojgan Masoodi

In mammals, glycogen synthesis and degradation are dynamic processes regulating blood and cerebral glucose-levels within a well-defined physiological range. Despite the essential role of glycogen in hepatic and cerebral metabolism, its spatiotemporal distr ...

Elsevier Science Bv2015

Photoinduced Nonpersistent Radicals as Polarizing Agents for X-Nuclei Dissolution Dynamic Nuclear Polarization

Arnaud Comment, Jacques Van Der Klink, Giovanni Boero, Christophe Roussel, Tian Cheng, Tim Rolf Eichhorn, Jean-Noël Hyacinthe, Andrea Capozzi

Hyperpolarization via dissolution dynamic nuclear polarization (DNP) is a versatile method to dramatically enhance the liquid-state NMR signal of X-nuclei and can be used for performing metabolic and molecular imaging. It was recently demonstrated that ins ...

American Chemical Society2015

Direct noninvasive estimation of myocardial tricarboxylic acid cycle flux in vivo using hyperpolarized 13C magnetic resonance

Arnaud Comment, Rolf Gruetter, Hongxia Lei, Tian Cheng, Josefina Adriana Maria Bastiaansen

BACKGROUND: The heart relies on continuous energy production and imbalances herein impair cardiac function directly. The tricarboxylic acid (TCA) cycle is the primary means of energy generation in the healthy myocardium, but direct noninvasive quantificati ...

Elsevier2015

Real time measurement of myocardial substrate selection in vivo using hyperpolarized 13C magnetic resonance

Arnaud Comment, Josefina Adriana Maria Bastiaansen

Taylor & Francis2015

An Intact Small Animal Model of Myocardial Ischemia-Reperfusion: Characterization of Metabolic Changes by Hyperpolarized 13C MR Spectroscopy

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara

Hyperpolarized carbon-13 magnetic resonance spectroscopy ((13)C MRS) enables the sensitive and noninvasive assessment of the metabolic changes occurring during myocardial ischemia-reperfusion. Ischemia-reperfusion models using hyperpolarized (13)C MRS are ...

2015

Metabolic flux analysis of hepatic mitochondrial oxidation of hyperpolarized [1-13C] and [2-13C] pyruvate in vivo

Arnaud Comment, Rolf Gruetter, Josefina Adriana Maria Bastiaansen, Emine Can, Hikari Ananda Infinity Yoshihara

2015

High-Precision MRI Reconstruction Algorithm for 3D Sphere Packings

Arnaud Comment, Daniele Mari, Alessandro Luigi Sellerio, Riccardo Balzan

Packings of granular materials are complex systems consisting of large sets of particles interacting via contact forces. Their internal structure is interesting for several theoretical and practical reasons, especially when the model system consists in a l ...

Springer Verlag2015

Radical-free mixture of co-polarized 13C metabolites for probing separate biochemical pathways in vivo by hyperpolarized 13C MR

Arnaud Comment, Rolf Gruetter, Josefina Adriana Maria Bastiaansen, Andrea Capozzi, Hikari Ananda Infinity Yoshihara

2015

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