Publications de Dominique Pioletti

Causal associations between scapular morphology and shoulder condition estimated with Bayesian statistics

Dominique Pioletti, Alexandre Terrier, Philippe Büchler

Background and Objective: While there is a reported correlation between shoulder condition and scapular morphology, the precise impact of typical anatomical variables remains a subject of ongoing debate. This study aimed to evaluate this causal association ...

2025

"Heat of the Moment: The Overlooked Key to Cartilage Engineering''

Dominique Pioletti, Theofanis Stampoultzis

Articular cartilage's limited regenerative capacity is compounded by the overlooked thermomechanical factors critical to its function. Recent studies emphasize the importance of cartilage self-heating, arising predominantly from energy dissipation under ph ...

AMER CHEMICAL SOC2025

Combining systemic and local osteoporosis treatments: A longitudinal in vivo microCT study in ovariectomized rats

Dominique Pioletti

Introduction: Managing osteoporotic patients at immediate fracture risk is challenging, in part due to the slow and localized effects of anti-osteoporotic drugs. Combining systemic anti-osteoporotic therapies with local bone augmentation techniques offers ...

2025

Helmet material design for mitigating traumatic axonal injuries through AI-driven constitutive law enhancement

Dominique Pioletti, Pierre-Etienne Bourban, Naser Nasrollahzadeh Mamaghani, Vincent Marc Varanges

Sports helmets provide incomplete protection against brain injuries. Here we aim to improve helmet liner efficiency by employing a novel approach that optimizes their properties. By exploiting a finite element model that simulates head impacts, we develope ...

2025

Design of Customized Mouthguards with Superior Protection Using Digital-Based Technologies and Impact Tests

Dominique Pioletti, Martin Broome, Naser Nasrollahzadeh Mamaghani

Background In contact sports, an impact on the jaw can generate destructive stress on the tooth-bone system. Mouthguards can be beneficial in reducing the injury risk by changing the dynamics of the trauma. The material properties of mouthguards and their ...

Springer2024

Cartilage Repair: Promise of Adhesive Orthopedic Hydrogels

Dominique Pioletti, Lee Ann Laurent-Applegate, Peyman Karami

Cartilage repair remains a major challenge in human orthopedic medicine, necessitating the application of innovative strategies to overcome existing technical and clinical limitations. Adhesive hydrogels have emerged as promising candidates for cartilage r ...

MDPI2024

Banked Primary Progenitor Cells for Allogeneic Intervertebral Disc (IVD) Therapy: Preclinical Qualification and Functional Optimization within a Cell Spheroid Formulation Process

Dominique Pioletti

Background/Objectives: Biological products are emerging as therapeutic management options for intervertebral disc (IVD) degenerative affections and lower back pain. Autologous and allogeneic cell therapy protocols have been clinically implemented for IVD r ...

2024

Impact of Molecular Dynamics of Polyrotaxanes on Chondrocytes in Double-Network Supramolecular Hydrogels under Physiological Thermomechanical Stimulation

Dominique Pioletti, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Hyaline cartilage, a soft tissue enriched with a dynamic extracellular matrix, manifests as a supramolecular system within load-bearing joints. At the same time, the challenge of cartilage repair through tissue engineering lies in replicating intricate cel ...

American Chemical Society2024

An Adhesive Hydrogel Technology for Enhanced Cartilage Repair: A Preliminary Proof of Concept

Dominique Pioletti

Knee cartilage has limited natural healing capacity, complicating the development of effective treatment plans. Current non-cell-based therapies (e.g., microfracture) result in poor repair cartilage mechanical properties, low durability, and suboptimal tis ...

2024

Customized modular multi-material mouthguard and method of making the same

Dominique Pioletti, Martin Broome, Naser Nasrollahzadeh Mamaghani

There is described a mouthguard comprising an externally exposed impact protective region defined by a first material property and configured to cover a front tooth, an internally exposed occlusional cushioning region defined by a second material property ...

2024

Development and Performance Evaluation of Hybrid Iono-organogels for Efficient Impact Mitigation

Dominique Pioletti, Pierre-Etienne Bourban, Vincent Marc Varanges, Vijay Kumar Rana

Dissipative materials are essential for mitigating impact in various automotive, aerospace, and sports equipment applications. This study investigates the efficiency of a novel hybrid iono-organogel in dissipating and absorbing impact energies. The gel con ...

American Chemical Society (ACS)2024

Glenohumeral joint force prediction with deep learning

Dominique Pioletti, Alexandre Terrier, Philippe Büchler, Patrick Goetti

Deep learning models (DLM) are efficient replacements for computationally intensive optimization techniques. Musculoskeletal models (MSM) typically involve resource-intensive optimization processes for determining joint and muscle forces. Consequently, DLM ...

Elsevier Sci Ltd2024

Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation

Dominique Pioletti, François Gorostidi, Theofanis Stampoultzis, Yanheng Guo, Ece Uslu, Vijay Kumar Rana

Tissue wounds are a significant challenge for the healthcare system, affecting millions globally. Current methods like suturing and stapling have limitations as they inadequately cover the wound, fail to prevent fluid leakage, and increase the risk of infe ...

Amer Chemical Soc2023

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Ulrike Kettenberger, Frédérica Schyrr, Alessia Perino, Alejandro Alonso Calleja, Antoine Jalil

Smw Supporting Association2023

Wet adhesive hydrogels to correct malacic trachea (tracheomalacia) A proof of concept

Dominique Pioletti, Nikolaos Stergiopoulos, Peyman Karami, Ece Uslu, Vijay Kumar Rana, Sokratis Anagnostopoulos

Tracheomalacia (TM) is a condition characterized by a weak tracheal cartilage and/or muscle, resulting in excessive collapse of the airway in the newborns. Current treatments including tracheal reconstruction, tracheoplasty, endo- and extra-luminal stents ...

CELL PRESS2023

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Unraveling cartilage degeneration through synergistic effects of hydrostatic pressure and biomimetic temperature increase

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo, Vijay Kumar Rana

Cartilage degeneration, typically viewed as an irreversible, vicious cycle, sees a significant reduction in two essential biophysical cues: the well-established hydrostatic pressure (HP) and the recently discovered transient temperature increase. Our study ...

Cell Press2023

A guide to preclinical evaluation of hydrogel-based devices for treatment of cartilage lesions

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis, Yanheng Guo

The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...

ELSEVIER SCI LTD2023

Age- and sex-specific normative values of bone mineral density in the adult glenoid

Dominique Pioletti, Alexandre Terrier, Philippe Büchler, Alain Farron, Frédéric Vauclair, Patrick Goetti

The objective of this study was to determine the normative bone mineral density (BMD) of cortical and trabecular bone regions in the adult glenoid and its dependence on the subject's age and sex. We analyzed computed tomography (CT) scans of 441 shoulders ...

WILEY2022

Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

Dominique Pioletti, Naser Nasrollahzadeh Mamaghani, Peyman Karami, Jian Wang, Yanheng Guo

During loading of viscoelastic tissues, part of the mechanical energy is transformed into heat that can locally increase the tissue temperature, a phenomenon known as self-heating. In the framework of mechanobiology, it has been accepted that cells react a ...

eLIFE SCIENCES PUBL LTD2022