Publications de Heinrich Hofmann

Factors influencing safety and efficacy of intravenous iron-carbohydrate nanomedicines: From production to clinical practice

Iron deficiency is an important subclinical disease affecting over one billion people worldwide. A growing body of clinical records supports the use of intravenous iron-carbohydrate complexes for patients where iron replenishment is necessary and oral iron ...

2020

The impact of synthetic amorphous silica (E 551) on differentiated Caco-2 cells, a model for the human intestinal epithelium

Heinrich Hofmann

For several decades, food-grade synthetic amorphous silica (SAS) have been used as a technological additive to reduce caking of food powders. Human exposure is thus inevitable and safety concerns are taken seriously. The toxicity of silica in general and S ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Beyond Unpredictability: The Importance of Reproducibility in Understanding the Protein Corona of Nanoparticles

Heinrich Hofmann, Sandra Caroline Galmarini, Diego Chiappe, Lionel André Maurizi, Nadia Rachel Von Moos, Noëlie Cayla

While it is well established that the surface of a nanoparticle plays a pivotal role for the protein corona, the vast number of proteins present in biological media render general conclusions about affinities between nanoparticle surfaces and proteins nont ...

AMER CHEMICAL SOC2018

Characterization of liposome-containing SPIONs conjugated with anti-CD20 developed as a novel theranostic agent for central nervous system lymphoma

Heinrich Hofmann, Lionel André Maurizi

2018

Fungicidal PMMA-Undecylenic Acid Composites

Dominique Bonvin, Heinrich Hofmann, Marijana Mionic Ebersold, Milica Petrovic

2018

Hexosomes with Undecylenic Acid Efficient against Candida albicans

Dominique Bonvin, Heinrich Hofmann, Marijana Mionic Ebersold, Milica Petrovic

2018

Nanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate)

Heinrich Hofmann

2018

Neglected nano-effects of nanoparticles in the interpretation of their toxicity

Dominique Bonvin, Heinrich Hofmann, Marijana Mionic Ebersold

2018

Functionalization of iron oxide nanoparticles with methacrylate-based monomers for preparation of nanocomposites

Heinrich Hofmann

Nanocomposites with a high and uniform loading of magnetic nanoparticles are very desirable for various applications. In this study, a simple and scalable route for preparing nanocomposites with a high and uniform loading of magnetic nanoparticles is prese ...

AMER INST PHYSICS2018

Critical raw materials: A perspective from the materials science community

Heinrich Hofmann

Functional materials are crucial to meet today's societal challenges and needs, such as the transition towards low carbon energy production to reduce climate change, renewable energies and green economy, clean mobility and improved communication. In order ...

ELSEVIER SCIENCE BV2018

Versatility of Pyridoxal Phosphate as a Coating of Iron Oxide Nanoparticles

Heinrich Hofmann, Ulrich Aschauer, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

Pyridoxal 5'-phosphate (PLP) is the most important cofactor of vitamin B-6-dependent enzymes, which catalyses a wide range of essential body functions (e.g., metabolism) that could be exploited to specifically target highly metabolic cells, such as tumour ...

Mdpi Ag2017

Controlling structural and magnetic properties of IONPs by aqueous synthesis for improved hyperthermia

Heinrich Hofmann, Alla Arakcheeva, Marijana Mionic Ebersold, Débora Bonvin

Iron oxide nanoparticles (IONPs) were synthesized by a novel aqueous synthesis route which combines co-precipitation (CP) and hydrothermal (HT) treatment, termed CP + HT, and compared with IONPs obtained by the standard CP method. Properties of both types ...

2017

ATP and NADPH coated iron oxide nanoparticles for targeting of highly metabolic tumor cells

Dominique Bonvin, Heinrich Hofmann

The metabolic activity of tumor cells is known to be higher as compared to that of normal cells, which has been previously exploited to deliver nanomedicines to highly metabolic tumor cells. Unfortunately, current strategies, which are mostly based on comp ...

Royal Society of Chemistry2017

Folic acid on iron oxide nanoparticles: platform with high potential for simultaneous targeting, MRI detection and hyperthermia treatment of lymph node metastases of prostate cancer

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

The overexpression of the folate receptor in most cancers has been widely exploited to specifically deliver folic acid (FA) coupled nanomedicines to tumors. However, complex coupling chemistry is often used to bind FA to the nanoparticles. Furthermore, ver ...

Royal Society of Chemistry2017

Assessment of nanoparticles’ safety: corrected absorbance-based toxicity test

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin

We developed a method to correct absorbance-based toxicity tests to remove the influence of the deposited dose of nano-particles. As a model of absorbance-based toxicity tests, we chose the frequently used MTS test. The corrected cell viabilities obtained ...

Royal Soc Chemistry2017

Chelating agents as coating molecules for iron oxide nanoparticles

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin, Josefina Adriana Maria Bastiaansen

Due to their high chemical affinity towards metal ions, chelating agents (CAs) have been used for decades for water purification, but also for protection against metal intoxication and in nanomedicine as linking molecules at the surface of nanoparticles. H ...

RSC Publishing2017

Hydrothermal growth of iron oxide NPs with a uniform size distribution for magnetically induced hyperthermia: Structural, colloidal and magnetic properties

Olivier Jordan, Heinrich Hofmann, Kurt Schenk

Magnetic iron oxide nanoparticles with a narrow size distribution were synthesized by hydrothermally treating suspensions of iron oxide nanoparticles. Ricinoleic-acid-coated magnetic nanoparticles were co precipitated at room temperature from an aqueous so ...

Elsevier2017

Methods of protein corona isolation for magnetic nanoparticles

Heinrich Hofmann, Marc Moniatte, Diego Chiappe, Marijana Mionic Ebersold, Débora Bonvin

Nanoparticles (NPs) in contact with a biological environment get covered by proteins and some are loosely bound and some are tightly bound. The latter form a hard protein corona (HPC) which is known to determine their biological behavior. Therefore, in ord ...

Royal Soc Chemistry2017

Superparamagnetic nanohybrids with cross-linked polymers providing higher in vitro stability

Heinrich Hofmann, Lionel André Maurizi

A simple, rapid, reproducible, and scalable method for generating highly stable cross-linked superparamagnetic nanohybrids was developed. Pre-coating of superparamagnetic iron oxide nanoparticle surfaces with a biocompatible polymer, hydroxy polyvinyl alco ...

Springer Verlag2017

Study and characterization of soft magnetic materials for beam intensity monitors at CERN

Heinrich Hofmann, Silvia Aguilera Murciano

At CERN, the circulating beam current measurement is provided by two types of transformers, the DC Current Transformer (DCCT) and the Fast Beam Current Transformer (FBCT). Each transformer is built based on toroidal cores made from a magnetic material. Dep ...

Iop Publishing Ltd2017