Publications de Stephan Morgenthaler

Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression

Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC deaths can be reduced with prevention and early diagnosis. Circulating tumor DNA-based liquid biopsies, are emerging tools for cancer detection. However, ...

2024

Innovative Biomarkers for Obesity and Type 1 Diabetes Based on Bifidobacterium and Metabolomic Profiling

Stephan Morgenthaler, Paul Refinetti, Mariya Yuryevna Skvortsova

The role of Bifidobacterium species and microbial metabolites such as short-chain fatty acids (SCFAs) and human milk oligosaccharides in controlling intestinal inflammation and the pathogenesis of obesity and type 1 diabetes (T1D) has been largely studied ...

MDPI2024

Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars

Stephan Morgenthaler, Richard Irving Anderson

All rights reserved.Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of 0.18âÃ Â€ ³ in the optical, making it an ideal instrument to search for gravitatio ...

2024

Gaia Focused Product Release: Radial velocity time series of long-period variables

Stephan Morgenthaler, Shuangqing Liao

Context. The third Gaia Data Release (DR3) provided photometric time series of more than 2 million long-period variable (LPV) candidates. Anticipating the publication of full radial-velocity data planned with Data Release 4, this Focused Product Release (F ...

Edp Sciences S A2023

Gaia Focused Product Release: Asteroid orbital solution: Properties and assessment

Stephan Morgenthaler, Shuangqing Liao

Context. We report the exploitation of a sample of Solar System observations based on data from the third Gaia Data Release (Gaia DR3) of nearly 157 000 asteroids. It extends the epoch astrometric solution over the time coverage planned for the Gaia DR4, w ...

Edp Sciences S A2023

Gaia Focused Product Release: Sources from Service Interface Function image analysis Half a million new sources in omega Centauri

Stephan Morgenthaler, Shuangqing Liao

Context.Gaia's readout window strategy is challenged by very dense fields in the sky. Therefore, in addition to standard Gaia observations, full Sky Mapper (SM) images were recorded for nine selected regions in the sky. A new software pipeline exploits the ...

Edp Sciences S A2023

Gaia Focused Product Release: Spatial distribution of two diffuse interstellar bands

Stephan Morgenthaler, Shuangqing Liao

Diffuse interstellar bands (DIBs) are absorption features seen in optical and infrared spectra of stars and extragalactic objects that are probably caused by large and complex molecules in the galactic interstellar medium (ISM). Here we investigate the Gal ...

Edp Sciences S A2023

A comprehensive error rate for multiple testing

Stephan Morgenthaler, Jean-Philippe Thiran, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville

Over the last two decades, a large variety of type I error rates and control procedures have been proposed in the field of multiple hypotheses testing. This paper proposes a framework that includes many existing proposals by investigating procedures in whi ...

SPRINGER2020

Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations

Stephan Morgenthaler, Paul Refinetti, Per Olaf Ekstrom

Background ...

FRONTIERS MEDIA SA2020

Identifying gene function and module connections by the integration of multispecies expression compendia

Stephan Morgenthaler, Elena Katsyuba, Kristina Schoonjans, Johan Auwerx, Fabrice David, Maroun Bou Sleiman, Daria Rukina, Andrea Komljenovic, Hao Li, Qingyao Huang, Yang Li, Changmyung Oh, Wen Gao

The functions of many eukaryotic genes are still poorly understood. Here, we developed and validated a new method, termed GeneBridge, which is based on two linked approaches to impute gene function and bridge genes with biological processes. First, Gene-Mo ...

Cold Spring Harbor Laboratory2019

Gaia Data Release 2 Variable stars in the colour-absolute magnitude diagram

Stephan Morgenthaler, Mikaël Martino, Jean-Marie Petit, Shuangqing Liao

Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G less than or similar to 21 mag. ...

EDP SCIENCES S A2019

Analysis of NGS-based blood immune cell RNA signatures for colorectal cancer detection

Stephan Morgenthaler, Paolo Angelino, Sahar Hosseinian Ehrensberger, Helen Lindsay

OXFORD UNIV PRESS2019

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function

Stephan Morgenthaler, Kristina Schoonjans, Johan Auwerx, Maroun Bou Sleiman, Hongbo Zhang, Daria Rukina, Karim Laurent Gariani, Xu Wang, Tao Lin, Peiling Luan, Hao Li, Vincenzo Sorrentino, Qingyao Huang, Naveed Ziari

2018

Gaia Data Release 2 Summary of the variability processing and analysis results

Stephan Morgenthaler, Mária Süveges, Lorenzo Diana

Context. The Gaia Data Release 2 (DR2) contains more than half a million sources that are identified as variable stars. ...

EDP SCIENCES S A2018

Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture microdissection and cycling temperature capillary electrophoresis

Stephan Morgenthaler, Paul Refinetti, Per Olaf Ekstrom

Background: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occu ...

BioMed Central2017

Gaia Data Release 1 Open cluster astrometry: performance, limitations, and future prospects

Stephan Morgenthaler, Mikaël Martino, Shuangqing Liao

Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 po ...

Edp Sciences S A2017

Testing parallaxes with local Cepheids and RR Lyrae stars

Stephan Morgenthaler, Mikaël Martino, Shuangqing Liao

Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the HIPPARCOS and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Ai ...

Edp Sciences S A2017

Indicators of Evidence for Bioequivalence

Stephan Morgenthaler, Robert Staudte

Some equivalence tests are based on two one-sided tests, where in many applications the test statistics are approximately normal. We define and find evidence for equivalence in Z-tests and then one-and two-sample binomial tests as well as for t-tests. Mult ...

Mdpi Ag2016

Gaia Data Release 1 Summary of the astrometric, photometric, and survey properties

Stephan Morgenthaler, Mikaël Martino, Shuangqing Liao

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. Aims. A summary of Gaia DR1 is presented along with illu ...

EDP Sciences2016

Predicting Individual Scores From Resting State fMRI Using Partial Least Squares Regression

Stephan Morgenthaler, Djalel Eddine Meskaldji, Dimitri Nestor Alice Van De Ville, Thomas William Arthur Bolton, Maria Giulia Preti

An important question in neuroscience is to reveal the relationship between individual performance and brain activity. This could be achieved by applying model regression techniques, in which functional connectivity derived from resting-state functional ma ...

Ieee2016